Navigation Links
Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits
Date:5/13/2011

f brain connections," he said. Still, he said, with the passage of time and when exacerbated by other factors, such as normal neuron death as we age and plaque and tangle development in the early stages of Alzheimer's reduced myelin integrity could facilitate cognitive impairment.

"So it's unlikely we are seeing the earliest possible signs of Alzheimer's-associated brain changes in these young people," Thompson said. "It's more likely the reduced fiber integrity represents an early developmental vulnerability that may reduce brain resilience to later Alzheimer's disease pathology. Inn other words, its mechanism of action may not be part of the classic Alzheimer's pathways that lead to abnormal amyloid plaque and neurofibrillary tangle accumulation in the brain."

The mapping of structural brain differences in those at genetic risk for Alzheimer's disease is crucial for evaluating treatment and prevention strategies, Thompson said. Once identified, brain differences can be monitored to determine how lifestyle choices influence brain health and disease risk.

"We know that many lifestyle factors, such as regular exercise and a healthful diet, may reduce the risk of cognitive decline, particularly in those genetically at risk for Alzheimer's, so this reminds us how important that is," he said.


'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
2. In lung cancer, silencing one crucial gene disrupts normal functioning of genome
3. Stress disrupts human thinking, but the brain can bounce back
4. Artificial light at night disrupts cell division
5. Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
6. Old and young brains rely on different systems to remember emotional content
7. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
8. Our brains make their own marijuana: Were all pot heads deep inside
9. Snakes and how they helped our big brains evolve
10. Monkey brains signal the desire to explore
11. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... solutions, today announced that members of the executive management ... Pacific Crest Global Technology Leadership Forum on Tuesday, August ... will be held at the Sonnenalp Resort in ... presentation may include forward-looking information. An audio webcast of ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... of the most common pathological changes after epileptic ... considered to be closely related with temporal lobe ... or synaptic remodeling in hippocampal CA3 pyramidal cells, ... synaptic circuits, thereby increasing epileptic susceptibility. Exogenous neuropeptide ...
... JoVE, the Journal of Visualized Experiments will publish ... the genes that govern food-related behavior in honey bees. ... closer toward understanding and perhaps changing undesirable ... technique has already helped to unravel [the] complex gene ...
... The science-based management and governance of shared transboundary water ... articles now published in a special edition of the ... of the Global Environmental Facility,s IW:LEARN project and the ... the special open-access volume includes a treasury of articles ...
Cached Biology News:Honey bee gene targeting offers system to understand food-related behavior 2Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 2Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 3Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 4Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 5
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Halozyme Therapeutics, ... Update Conference Call for the second quarter 2015 on ... PT. Dr. Helen Torley , president and chief ... date post-market, Halozyme will release financial results for the ... webcast live through the "Investors" section of Halozyme,s corporate ...
(Date:8/3/2015)... ... 03, 2015 , ... The synthetic rubber industry is recognized ... as ethylbenzene, a precursor to styrene, used to make styrene-butadiene resins, styrene butadiene ... production of tyres and other components. Thus, growth in the automotive industry is ...
(Date:8/3/2015)... 3, 2015 E-QURE Corp. (OTCQB: ... its Bio-electrical Signal Therapy device ("BST Device"), a new ... to heal chronic wounds, today announced that the Company ... Israeli distributor specializing in medical devices, for the marketing ... is a 70 years old, sales, marketing and distribution ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sterlitech Corporation introduces the compact, ... of analytical laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an ... and maintenance-free solution for a broad range of vacuum filtration applications. , Featuring ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Sterlitech Launches New Line of Vacuum Pumps 2
... Bioscience announced today that it has been awarded ... from the United,States Defense Threat Reduction Agency (DTRA) ... a broad spectrum therapeutic for the treatment,of a ... is melioidosis which is the most common cause ...
... Office and Expanded Team Demonstrates USC,s Increased ... Positions USC to Strengthen and Leverage Robust ... ANGELES, Oct. 8 In a move that,demonstrates ... breakthrough research in the biosciences, the USC,Stevens Institute ...
... will market Salugen,s DNA-customized nutritional solutions ... ... Oct. 19 Salugen(R) ( http://www.salugen.com ),a leading personalized ... Southfield, Michigan to distribute Salugen,s,nutritional gene testing and DNA-customized ...
Cached Biology Technology:Implicit Awarded US $16.3 Million U.S. Government Contract to Develop Immunomodulatory Drug for Biodefense Threats 2The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 2The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 3The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 4Salugen Expands U.S. Distribution and Announces a Partnership with DNA Dimensions to Bring DNA Customized Nutritional Solutions to Metro Detroit Area 2Salugen Expands U.S. Distribution and Announces a Partnership with DNA Dimensions to Bring DNA Customized Nutritional Solutions to Metro Detroit Area 3
... Product Goat polyclonal to Cholesterol ... Reactivity / Specificity Cross-reacts with ... Background Information Cholesterol oxidases exist ... oxidases and are implicated in bacterial pathogenesis. ...
Phospho-PERK (Thr980) Antibody...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: