Navigation Links
Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits
Date:5/13/2011

distinct profile of lower white matter integrity that may increase vulnerability to developing the disease later in life.

The discovery of what this gene does is interesting on several levels, said Thompson, the senior author of the study.

"For example, Alzheimer's has traditionally been considered a disease marked by neuronal cell loss and widespread gray-matter atrophy," he said. "But degeneration of myelin in white-matter fiber pathways is more and more being considered a key disease component and another possible pathway to the disease, and this discovery supports that."

Thompson said four things are surprising with the discovery of this gene's function:

  1. This risk gene damages your brain a full 50 years before people normally get Alzheimer's. The damage can be seen on an MRI scan, but there are no symptoms yet.

  2. It's now known what this mysterious gene does namely, make your brain wiring vulnerable to attack by impairing the wiring before any senile plaques or tangles develop.

  3. Rather than being a gene that few people have, a whopping 88 percent of Caucasians have it. "So I guess you could say the other 12 percent have an 'Alzheimer's resistance gene' that protects their brain wiring," said Thompson, who is also a member of UCLA's Laboratory of Neuro Imaging and the UCLA Brain Research Institute.

  4. Finally, he said, knowing the role of this gene is useful in predicting a person's risk of the disease and in seeing if you can step in and protect the brain in the 50-year time window you have before the disease begins to develop.

Of course, the obvious question is if most of us have this "bad" gene, why isn't Alzheimer's rampant in young people?

Less myelination in CLU-C carriers may not translate into poorer cognition in youth, said Thompson, because the brain can compensate. "The brain has a lot of built in redundancy miles and miles o
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
2. In lung cancer, silencing one crucial gene disrupts normal functioning of genome
3. Stress disrupts human thinking, but the brain can bounce back
4. Artificial light at night disrupts cell division
5. Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
6. Old and young brains rely on different systems to remember emotional content
7. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
8. Our brains make their own marijuana: Were all pot heads deep inside
9. Snakes and how they helped our big brains evolve
10. Monkey brains signal the desire to explore
11. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... for Integrative Legume Research (CILR) has lodged a complete ... CILR researchers screened legumes (plants which obtain useable nitrogen ... and they identified a number of compounds which could ... tumours. Without an adequate blood supply tumours stop growing ...
... can retain a good memory even in your twilight years ... believe they can control their memory are more likely to ... march of time. These are the conclusions of a new ... , The study demonstrates a link between actual cognitive functioning ...
... differences between humans and chimpanzees are due more to ... themselves, researchers from Yale, the University of Chicago, and ... the 9 March 2006 issue of the journal ... for a 30-year-old theory, proposed in a classic paper ...
Cached Biology News:Legume compounds may help cancer treatment 2Confidence in memory performance helps older adults remember 2Most human-chimp differences due to gene regulation ?not genes 2Most human-chimp differences due to gene regulation ?not genes 3
(Date:3/25/2015)... 25, 2015 Having added two International ... part of 2014, ITRA Global proudly announced recently the ... Tenant Representative Alliance, based in the United States, is ... and occupiers of commercial real estate. , Saltwood ... in Poland that exclusively advises occupiers of office space, ...
(Date:3/25/2015)... the HAGUE, Netherlands , March 25, ... LES Stimulation therapy for chronic gastro-esophageal reflux disease (GERD) ... [ Surgery . 2015; 157(3):556-567 ], establishing ... therapy. The study included 25 patients ... years and taking prescribed daily proton pump inhibitor (PPI) ...
(Date:3/25/2015)... 2015 /CNW/ - The Gairdner Foundation is pleased ... Awards, recognizing some of the most significant medical ... Among the world,s most esteemed medical research prizes, ... provide a $100,000 (CDN) prize to each scientist for their ... research and innovation across the country, inspiring the ...
(Date:3/25/2015)... 2015 FDNA®, the pioneer in ... Face2Gene, allowing geneticists around the globe to ... as mobile devices. Face2Gene® facilitates detection of facial dysmorphic ... comprehensive and up-to-date genetic references. The date of the ... 2015, in Salt Lake City, UT ...
Breaking Biology Technology:International Organization Expands its Global Reach to Warsaw, Poland 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2
... EST, HOPKINTON, Mass., Oct. 23 Caliper ... a conference call discussing the,company,s third quarter 2008 ... 10. Kevin Hrusovsky, President and Chief Executive Officer ... call. Management will,discuss operational and financial results and ...
... Oct. 23 Techne Corporation,(Nasdaq: TECH ) announced ... a dividend of $0.25 per share for the quarter ... November 17, 2008 to all common,shareholders of record on ... Chairman and Chief Executive,Officer, said, "I am very pleased ...
... 23 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,ONC, ... entitled "A Phase I,Study to Evaluate Systemic ... Patients with Advanced Malignancies" will be available ... Immunotherapy, the official,journal of the International Society ...
Cached Biology Technology:Caliper Life Sciences' Third Quarter 2008 Financial Results Conference Call Notice 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 3