Navigation Links
Alzheimer's risk gene disrupts brain's wiring 50 years before disease hits
Date:5/13/2011

What if you were told you carried a gene that increases your risk for Alzheimer's disease? And what if you were told this gene starts to do its damage not when you're old but when you're young?

Brace yourself.

Scientists know there is a strong genetic component to the development of late-onset Alzheimer's. In 1993, researchers discovered a gene known as ApoE4 carried by about a quarter of us that triples the risk for getting Alzheimer's. In 2009, three more risky genes were discovered, and one of them, called clusterin, or CLU, was found to up the risk of getting Alzheimer's by another 16 percent.

But nobody could explain what the CLU gene actually did. Now, UCLA researchers know, and the explanation is a doozy: This risk gene begins to damage your brain a full 50 years before people normally get Alzheimer's.

In the current online edition of the Journal of Neuroscience, Paul Thompson, a UCLA professor of neurology, and his colleagues report that the C-allele of the CLU gene (an allele is one of two or more forms of a gene), which is possessed by 88 percent of Caucasians, impairs the development of myelin, the protective covering around the neuron's axons in the brain, making it weaker and more vulnerable to the onset of Alzheimer's much later in life.

The researchers scanned the brains of 398 healthy adults ranging in age from 20 to 30 using a high-magnetic-field diffusion scan (called a 4-Tesla DTI), a newer type of MRI that maps the brain's connections. They compared those carrying a C-allele variant of the CLU gene with those who had a different variant, the CLU T-allele.

They found that the CLU-C carriers had what brain-imaging researchers call lower "fractional anisotropy" a widely accepted measure of white-matter integrity in multiple brain regions, including several known to degenerate in Alzheimer's. In other words, young, healthy carriers of the CLU-C gene risk variant showed a
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Neurimmune Therapeutics Announces Advancement of Alzheimers Program into Preclinical Development
2. In lung cancer, silencing one crucial gene disrupts normal functioning of genome
3. Stress disrupts human thinking, but the brain can bounce back
4. Artificial light at night disrupts cell division
5. Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
6. Old and young brains rely on different systems to remember emotional content
7. Rice University psychologist finds womens brains recognize, encode smell of male sexual sweat
8. Our brains make their own marijuana: Were all pot heads deep inside
9. Snakes and how they helped our big brains evolve
10. Monkey brains signal the desire to explore
11. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
(Date:10/15/2014)... the pandemic risk from strains of influenza virus increases ... ourselves to become complacent that the most substantial threats ... , Influenza pandemics arise when a new virus strain ... immunity – spreads in the human population. There have ... the worst of which – the 1918 Spanish Flu ...
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
Breaking Biology News(10 mins):New perspectives for development of an RSV vaccine 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... method to identify DNA mutations may shepherd in an ... screening and identification of genes that harbor disease. , ... Biosensors at the Biodesign Institute at ASU, led a ... of biosensors, electronics, and nanotechnology to fashion nanocrystals that ...
... provide for study of human immune responses, scientists have ... rapid immune response by two separate armies of defensive ... microbes like the leprosy bug, this initial defense sometimes ... yields to a dangerous, spreading infection. , Led by ...
... University of North Carolina at Chapel Hill is one ... the National Institutes of Health to study why good ... the next seven years, the Drug-Induced Liver Injury Network, ... liver injury caused by prescription and over-the-counter medications, nutritional ...
Cached Biology News:Bioelectronic ‘signatures?hold key to DNA mutations 2Leprosy microbes lead scientists to immune discovery 2UNC launches study of liver injury caused by drugs 2
(Date:10/20/2014)... 2014 Local veterinary surgeon, Dr. Tim ... study of donor stem cells for dogs with osteoarthritis. ... and has performed clinical stem cell therapy for 7 ... determine if a single injection of donor stem cells ... reduce pain and inflammation in the treated joints. ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The ... bromine market in Asia-Pacific with analysis and forecast ... the Asia Pacific Bromine Market report, to get ... also provides a glimpse of the segmentation in ... various tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report defines and segments ... forecast of revenue. This market is estimated to grow ... 2019, at a Compound Annual Growth Rate (CAGR) of ... TOC of the Asia-Pacific Speech Analytics market report to ... also provides a glimpse of the segmentation in the ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... CHAPEL HILL, N.C., Aug. 22 Quality and ... year in light of,demands for higher efficiencies fueled ... issues on multiple fronts --,smaller pipelines are affecting ... increasing and harsher FDA regulations brought more scrutiny ...
... non-profit, faith-based and community organizations to ... proactively get the job done, ... agreement with a non-profit organization to utilize its,Ogiene(TM) FE technology to ... safely used by those families so desperately in need,of biohazard-free housing., ...
... Cellular Platform Utilizing Cord, Blood and Menstrual Blood Derived Stem ... ... Vascular Structures, OLDSMAR, Fla., Aug. 21 Cryo-Cell,International, ... research collaboration to co-develop a combined cellular,platform therapeutic for rapidly ...
Cached Biology Technology:Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools 2BioNeutral Signs Agreement With a Non-profit for Long-Term Removal of Formaldehyde to Save 10,000 Mobile Homes in Louisiana 2Cryo-Cell International and EndGenitor Technologies Announce Research Collaboration 2Cryo-Cell International and EndGenitor Technologies Announce Research Collaboration 3Cryo-Cell International and EndGenitor Technologies Announce Research Collaboration 4
... structure has been determined, the challenge is ... diverse audience of scientists, educators and students. ... dissemination over the Internet, either via online ... Printed literature has the advantage of wide ...
ma. plate stack height 70mm...
Buckets for tube holder inserts...
...
Biology Products: