Navigation Links
Alzheimer's disease: Cutting off immune response promises new approach to therapy

The Bonn site of the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn are leading contributors.

The complex named "NLRP3 inflammasome" is composed of several proteins and plays a key role in the immune system. It resembles a fire alarm sensor that triggers a chain reaction when activated. As a result, immune cells are mobilized and substances that foster inflammation are released. This process can be triggered by infections, which are subsequently suppressed by the immune response. However, in the case of Alzheimer's disease, the activation of the molecular alarm may have negative consequences: nerve cells are damaged and die. Ultimately, this leads to the loss of brain function and mental capabilities in humans.

Alzheimer's disease is accompanied with deposits in the brain. That these so-called "plaques" have the capability to activate the NLRP3 inflammasome had already been identified by investigating individual cells. But the exact effect on the organism was unknown. "It was unclear what consequences an increased activity of the NLRP3 inflammasome could have on the brain," explains Prof. Michael Heneka, who conducts research at both, the DZNE and the University of Bonn. Working in a team with immune researcher Eicke Latz as well as with other colleagues, Heneka has now been able to show that the protein complex does in fact play a determining role in the development of Alzheimer's disease.

Studies involved humans and mice

The researchers collected a comprehensive chain of evidences: they examined both the brains of deceased Alzheimer patients and of mice who exhibited behavioural disorders that are typically associated with Alzheimer's disease. The researchers found an activated form of the NLRP3 inflammasome in both cases.

Looking at another group of mice, the scientists examined possibilities for suppressing inflammatory reactions. To achieve this, they removed the genes that trigger production of the NLRP3 inflammasome. Therefore, these mice were no longer able to synthesize the protein complex. As a result, the animals developed only relatively mild symptoms of the disease. Moreover, their brains showed only reduced amounts of the damaging plaques.

"We have stumbled upon a critical factor in the development process of Alzheimer's. Given these findings it appears to be a very promising possibility to block the activity of the inflammasome," comments Heneka. In his view, proper pharmaceuticals might be able to stop a chain reaction that would otherwise result in the inflammation of brain cells. "At present various options are being pursued to act upon the course of the disease," says the neuroscientist. "Our results points to a new possibility. Nevertheless, we are still in the process of doing basic research."

However, the group of scientists in Bonn is already making plans for the future. Eicke Latz's team, which also made significant contributions to the latest study, has already begun to search for active components that could block the NLRP3 inflammasome. "The testing of potential substances in the laboratory would be a next step. We hope to start as early as next year," says Heneka.


Contact: Dirk Frger
Helmholtz Association of German Research Centres

Related biology news :

1. New hope for treating Alzheimers Disease: A role for the FKBP52 protein
2. Therapies for spinal cord injury: On the cutting edge of clinical translation
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. UCI-led study uncovers how Salmonella avoids the bodys immune response
5. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
6. Immune system implicated in prematurity complication
7. Key to immune system disease could lie inside the cheek
8. New immune defense enzyme discovered
9. New genetic mechanism of immune deficiency discovered
10. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
11. Immune-response genes affecting breast tumor eradication
Post Your Comments:
(Date:10/29/2015)... 2015  Connected health pioneer, Joseph C. Kvedar ... technology-enabled health and wellness, and the business opportunities that ... The Internet of Healthy Things . Long before ... existed, Dr. Kvedar, vice president, Connected Health, Partners HealthCare, ... moving care from the hospital or doctor,s office into ...
(Date:10/27/2015)... JOSE, Calif. , Oct. 27, 2015 Synaptics ... interface solutions, today announced that Google has adopted the ... of touch controller solutions to power its newest flagship ... 6P by Huawei. --> ... partners like Google to provide strategic collaboration in the ...
(Date:10/23/2015)... GOLETA, California , October 23, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) announce a mobile plug and play ... during interactive real-world tasks SensoMotoric Instruments (SMI) ... their established wearable solutions for eye tracking and physiological ... captured with SMI Eye Tracking Glasses 2w ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015 Orexigen® Therapeutics, Inc. (Nasdaq: ... in a fireside chat discussion at the Piper Jaffray ... . The discussion is scheduled for Wednesday, December ... .  A replay will be available for 14 ... , Julie NormartVP, Corporate Communications and Business Development ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... were featured on AngelList early in their initial angel funding process. Now, they ... for individuals looking to make early stage investments in the microbiome space. ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... The United ... recipient of the 2016 USGA Green Section Award. Presented annually since 1961, the USGA ... his or her work with turfgrass. , Clarke, of Iselin, N.J., is ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be ... York on Wednesday, December 2 at 9:30 a.m. ET/6:30 ... CEO, will provide a corporate overview. th Annual ... 1:00 p.m. ET/10:00 a.m. PT . Jim Mazzola , ... corporate overview. --> th Annual Oppenheimer Healthcare Conference ...
Breaking Biology Technology: