A*STAR also will fund research projects on such neurodegenerative diseases as Alzheimer's and Parkinson's. At NUS, Gavin Dawe, Ph.D., and his colleagues will explore the signaling mechanisms behind Alzheimer's disease, building on the group's discovery of an important protein interaction that suppresses neural cell formation in the brains of mice, and that might be relevant to Alzheimer's, the most common form of dementia among older people.
"In this project, we will investigate whether this protein interaction also occurs in human stem cells and in the adult mouse brain, as well as how it influences stem cell function," said Dr. Dawe. "Our findings will increase our understanding of what these proteins do in the brain and in the long term, this knowledge may contribute to the development of treatments for Alzheimer's disease."
Among the recipients of grants to support cancer research is Shazib Pervaiz, Ph.D., of NUS for his team's examination of how statins cholesterol-lowering drugs may restrict growth and induce death of cancer cells.
"Current breast cancer therapies include surgery, anti-cancer drugs and radiation, which are invasive or run the risk of relapse," said Dr. Pervaiz. "Our team aims to characterise the interactions of statins with other proteins known to promote cell death and survival, and subsequently explore the potential for statins to fill the gap in novel strategies for more effective and less invasive treatment of breast and other forms of cancer."
BMRC Chairman Sir George Radda, Ph.D., said, "The grant calls underscore A*STAR's commitment to foster excellent scientific research and talent in Singapore. The wide range of research areas covered under the grant calls i
|Contact: Cathy Yarbrough|
Agency for Science, Technology and Research (A*STAR), Singapore