Navigation Links
Alzheimer’s disease consortium identifies four new genes for Alzheimer’s disease risk
Date:4/3/2011

(NEW YORK, NY, April 3, 2011) In the largest study of its kind, researchers from a consortium that includes Columbia University Medical Center identified four new genes linked to late-onset Alzheimer's disease. Each of these genes adds to the risk of developing this most common form of the disease, and together they offer a portal into the causes of Alzheimer's. Their identification will help researchers find ways to determine who is at risk of developing the disease, which will be critical as preventive measures become available, and to identify proteins and pathways for drug development. The findings appear in the current issue of Nature Genetics.

"A significant aspect of our research is that these genes clarify three new pathways," said Richard Mayeux, MD., MS., one of the lead scientists in the Alzheimer's Disease Genetics Consortium (ADGC) and Chairman of the Department of Neurology of Columbia University Medical Center. "APOE-e4 and the other genes identified earlier are related to the accumulation of amyloid in the brain; these new genes are involved in inflammatory processes, lipid metabolism, and the movement of molecules within cells. Therefore, we may now have four pathways that are critically related to the disease and that could really make a difference in how we study and potentially prevent and treat it."

(Dr. Mayeux is also the Gertrude H. Sergievsky Professor of Neurology, Psychiatry and Epidemiology; Director of the Gertrude H. Sergievsky Center, which is devoted to the epidemiological investigation of neurological diseases; and Co-Director of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center).

The study, conducted by the ADGC and led by the University of Pennsylvania School of Medicine, the University of Miami, Boston University School of Medicine and Columbia University, reports genetic analysis of more than 11,000 people with Alzheimer's and a nearly equal number of elderly people with no symptoms of dementia. Three other consortia provided additional, confirming data, bringing the total number of people studied to more than 54,000. The consortium also contributed to identification of a fifth gene, reported by other groups of investigators from the United States, the United Kingdom, France, and other European countries.

The study reflects the collaborative effort of investigators from 44 universities and research institutions in the United States, led by Gerard D. Schellenberg, PhD, at Penn, with primary analysis sites at Miami, led by Margaret A. Pericak-Vance, PhD, and at Boston, led by Lindsay A. Farrer, PhD.

"This is the culmination of years of work on Alzheimer's disease by a large number of scientists, yet it is just the beginning in defining how genes influence memory and intellectual function as we age. We're all tremendously excited by our progress so far, but much remains to be done, both in understanding the genetics and in defining how these genes influence the disease process," Schellenberg said.

Until recently, only four genes associated with late-onset Alzheimer's had been confirmed, with the gene for apolipoprotein E-e4 (APOE-e4) having the largest effect on risk. The Nature Genetics studies add another four: MS4A, CD2AP, CD33, and EPHA1. The studies also contributed to the identification and confirmation of two other genes, BIN1 and ABCA7.

The researchers' ultimate aims are two-fold. First, identification of new Alzheimer's disease genes will provide major clues as to its underlying cause. Genetic studies can also provide new insights into the molecules at the center of the disease. Such knowledge is critical for drug discovery, as currently available treatments are only marginally effective.

Second, gene discovery of the type highlighted in the Nature Genetics article will contribute to the ability to predict who is at greatest risk of developing Alzheimer's disease; this will be important as preventive measures become available. Identification of these risk genes will also help researchers to determine the disease-initiating steps that begin in the brain long before any symptoms of memory loss or intellectual decline are apparent. Eventually, it is hoped that researchers will be able to describe the events that lead to the destruction of large parts of the brain and, ultimately, complete loss of cognitive abilities.

Alzheimer's genetics researchers are currently joining forces for an even larger study. The Alzheimer's Association in the U.S. and the Fondation Plan Alzheimer in France have funded the formation of the International Genomics of Alzheimer's Project, whose members met for the first time in November 2010 in Paris.


'/>"/>
Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Related biology news :

1. 4 new genes identified for Alzheimers disease risk
2. New data show non-alcoholic fatty liver disease will reach epidemic status in the US
3. Probiotic bacteria could help treat Crohns disease
4. European-wide study confirms benefits of D-penicillamine and trientine for Wilson disease
5. UC Riverside researcher receives $9 million USDA grant to study potato and tomato disease
6. Kentucky researchers find a key to plant disease resistance
7. How do plants fight disease?
8. Asthma drug could help control or treat Alzheimers disease
9. Study shows living at high altitude reduces risk of dying from heart disease
10. Research may lead to new treatments for Parkinson’s disease and other neurological disorders
11. A dose of safflower oil each day might help keep heart disease at bay
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Kapstone Medical is proud to ... helping medical technology companies and inventors develop and safeguard their latest innovations. The ... firm with a portfolio of clients in the United States and around the world. ...
(Date:8/15/2017)... , ... August 15, 2017 , ... Any expert in ... has compromised these disciplines for more than half a century. Despite their essential ... It is widely known that molecular tags developed for this purpose also tag ...
(Date:8/15/2017)... ... 15, 2017 , ... Coffea arabica accounts for 70 percent ... During this educational webinar, participants will learn about the importance of genomics for ... understanding of how genomics is important for coffee breeding improvement. , Attendees will ...
(Date:8/14/2017)... ... 14, 2017 , ... Opal Kelly, a leading producer of ... announced the release of SYZYGY™, a new open standard for connecting high-performance peripherals ... compact, low cost, low pin-count, high-performance connectivity solution between FPGAs and single-purpose hardware ...
Breaking Biology Technology: