Navigation Links
Alternative target for breast cancer drugs
Date:7/19/2013

HEIDELBERG, 19 July 2013 Scientists have identified higher levels of a receptor protein found on the surface of human breast tumour cells that may serve as a new drug target for the treatment of breast cancer. The results, which are published today in EMBO Molecular Medicine, show that elevated levels of the protein Ret, which is short for "Rearranged during transfection", are associated with a lower likelihood of survival for breast cancer patients in the years following surgery to remove tumours and cancerous tissue.

"Our findings suggest that Ret kinase might be an attractive and novel alternative therapeutic target in selected groups of breast cancer patients," remarked Nancy Hynes, Professor at the Friedrich Miescher Institute for Biomedical Re-search and the University of Basel, Switzerland. "Initial experiments in mice that serve as model organisms for the study of breast cancer have revealed that specific inhibitors significantly block the spread of cancer and decrease the number of metastatic tumours found in the lungs."

The scientists examined tumour tissue microarrays of more than 100 breast cancer patients who had undergone surgery to remove their tumours. Antibodies were used to detect the levels of Ret in the samples. In other experiments, four different cancer cell lines were used and injected into mice to study the effects of Ret inhibitors on the progress and spread of the cancer.

"Our findings demonstrate that blocking Ret kinase not only decreases the growth of tumours but also impacts the potential of the cancer to spread throughout the body," Hynes said.

Targeting receptor tyrosine kinase enzymes with antibodies or small molecular inhibitors is a clinically validated approach for cancer therapy. However, only a subset of patients are eligible for these types of treatments which makes it essential to discover additional inhibitors that could be useful in breast cancer therapy.


'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1

Related biology news :

1. Study finds possible alternative to bariatric weight loss surgery
2. Study proposes alternative way to explain lifes complexity
3. Stanford researchers map out an alternative energy future for New York
4. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
5. Marginal lands are prime fuel source for alternative energy
6. Engineering alternative fuel with cyanobacteria
7. CCNY landscape architect offers storm surge defense alternatives
8. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
9. New process doubles production of alternative fuel while slashing costs
10. Toward an alternative for antibiotics to fight bacterial infections?
11. Amniotic fluid yields alternatives to embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... 2016 Research and Markets has ... Market 2016-2020"  report to their offering.  , ,     ... The analysts forecast the global multimodal biometrics market ... the period 2016-2020.  Multimodal biometrics is ... as the healthcare, BFSI, transportation, automotive, and government ...
(Date:4/14/2016)... , April 14, 2016 ... Malware Detection, today announced the appointment of Eyal ... new role. Goldwerger,s leadership appointment comes at ... heels of the deployment of its platform at several ... biometric technology, which discerns unique cognitive and physiological factors, ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
Breaking Biology News(10 mins):
(Date:5/20/2016)... Baltimore, MD (PRWEB) , ... May 20, 2016 , ... ... contaminated with Listeria, as reported by Food Safety News on May 12, 2016(1), demonstrates ... according to Ted Olsen, CEO of Baltimore-based biotech firm, PathSensors, Inc. ...
(Date:5/19/2016)... SAN DIEGO , May 19, 2016 /PRNewswire/ ... (OTCBB: RGBP), (OTC PINK: RGBP) and (OTC PINK: RGBPP) announced ... at creating the first cord blood based cancer ... a provisional patent application, Regen described a generation ... activity was potentiated by gene silencing.  The product ...
(Date:5/18/2016)... ... May 18, 2016 , ... STACS DNA Inc., the sample tracking software ... report sexual assault kit processing to help them save time and reduce errors. , ... kits to be processed and victims informed of results. Due to a previous lack ...
(Date:5/17/2016)... McKinney, Texas (PRWEB) , ... May 17, 2016 ... ... product for use in animal waste reduction applications, announced today it will be ... Des Moines, Iowa. , ManureMagicâ„¢ was featured in the Wall Street Journal last ...
Breaking Biology Technology: