Navigation Links
Alternative target for breast cancer drugs
Date:7/19/2013

HEIDELBERG, 19 July 2013 Scientists have identified higher levels of a receptor protein found on the surface of human breast tumour cells that may serve as a new drug target for the treatment of breast cancer. The results, which are published today in EMBO Molecular Medicine, show that elevated levels of the protein Ret, which is short for "Rearranged during transfection", are associated with a lower likelihood of survival for breast cancer patients in the years following surgery to remove tumours and cancerous tissue.

"Our findings suggest that Ret kinase might be an attractive and novel alternative therapeutic target in selected groups of breast cancer patients," remarked Nancy Hynes, Professor at the Friedrich Miescher Institute for Biomedical Re-search and the University of Basel, Switzerland. "Initial experiments in mice that serve as model organisms for the study of breast cancer have revealed that specific inhibitors significantly block the spread of cancer and decrease the number of metastatic tumours found in the lungs."

The scientists examined tumour tissue microarrays of more than 100 breast cancer patients who had undergone surgery to remove their tumours. Antibodies were used to detect the levels of Ret in the samples. In other experiments, four different cancer cell lines were used and injected into mice to study the effects of Ret inhibitors on the progress and spread of the cancer.

"Our findings demonstrate that blocking Ret kinase not only decreases the growth of tumours but also impacts the potential of the cancer to spread throughout the body," Hynes said.

Targeting receptor tyrosine kinase enzymes with antibodies or small molecular inhibitors is a clinically validated approach for cancer therapy. However, only a subset of patients are eligible for these types of treatments which makes it essential to discover additional inhibitors that could be useful in breast cancer therapy.


'/>"/>

Contact: Barry Whyte
communications@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1

Related biology news :

1. Study finds possible alternative to bariatric weight loss surgery
2. Study proposes alternative way to explain lifes complexity
3. Stanford researchers map out an alternative energy future for New York
4. Researchers find alternative cholesterol-lowering drug for patients who cant tolerate statins
5. Marginal lands are prime fuel source for alternative energy
6. Engineering alternative fuel with cyanobacteria
7. CCNY landscape architect offers storm surge defense alternatives
8. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
9. New process doubles production of alternative fuel while slashing costs
10. Toward an alternative for antibiotics to fight bacterial infections?
11. Amniotic fluid yields alternatives to embryonic stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... tumor cells has provided scientists at Dana-Farber Cancer Institute and ... an entirely new class of genes that may serve as ... reported in the Aug. 17 issue of the journal ... few of which had previously been identified as potential targets ...
... FASEB MARC (Maximizing Access to Research Careers) Program ... & Grant Writing Seminar Chantilly, VA from August 24-25, ... entry of underrepresented minority students, postdoctorates and scientists into ... are given to graduate students, postdocs and new assistant ...
... , EAST LANSING, Mich. A professor at Michigan ... new method of removing phosphorous from our wastewater ... country. In addition, Steven Safferman, an associate professor ... Ohio, based-MetaMateria Technologies, are devising a cost-effective way of ...
Cached Biology News:'CYCLOPS' genes may serve as an Achilles' heel in tumor cells 2'CYCLOPS' genes may serve as an Achilles' heel in tumor cells 3New method to remove phosphorous from wastewater 2
(Date:12/17/2014)... This report is a professional ... For an overview analysis, the report introduces quartz ... structure, industry overview, policy analysis, and news analysis, ... has witnessed rapid development with key manufacturers increasing ... report mentions quartz tubing upstream raw materials and ...
(Date:12/17/2014)... 17, 2014 Audacity, a leading California-based ... member of the Huntsworth Health Group, is proud to ... team. In her role, Gonzales will serve as Senior ... incredibly honored to welcome a talent of Jamie’s caliber ... Gaëtan Fraikin. “She is a proven healthcare innovation leader ...
(Date:12/17/2014)... -- CASI Pharmaceuticals, Inc. (Nasdaq: CASI ), ... commercialization of innovative therapeutics addressing cancer and other unmet ... commercial focus on China , today ... meeting with the U.S. Food and Drug Administration (FDA) ... 2015.  During this meeting the Company will seek guidance ...
(Date:12/15/2014)... METTLER TOLEDO is pleased to ... ParticleView V19 with PVM technology , is now ... and measurement tool continuously captures high-resolution images under ... then automatically prepares a report pairing the most ... concentration changes. This compelling blend of high resolution ...
Breaking Biology Technology:2020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Audacity Welcomes Healthcare Communications Expert Jamie Gonzales as Senior Vice President of Client Services 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 2CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 3CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 4CASI Pharmaceuticals Granted Type C Meeting With U.S. FDA For ENMD-2076 In Fibrolamellar Carcinoma 5New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2
... Inc.,(Nasdaq: OSTE ) announced today that the Company,s ... released Thursday, May 1, 2008. A,conference call will be ... well as other members of Osteotech management, on,Thursday, May ... invited to listen,to the conference call by dialing 1-706-643-1624. ...
... world,s leading,online bioscience job board community and life ... IBC Life Sciences whereby BioSpace will,produce a Life ... Discovery,& Development of Innovative Therapeutics World Congress (DDT) ... will be marketed and promoted to the 500,000 ...
... to Advance Product Pipeline with Increased Investment in ... Research & Development, ... reported solid financial results for,the first quarter of 2008, and raised its ... net income of $429 million, a 6,percent increase compared to $403 million ...
Cached Biology Technology:BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 2BioSpace and IBC Life Sciences Announce Career Fair Alliance For Drug Discovery & Development of Innovative Therapeutics World Congress 3Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 2Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 3Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 4Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 5Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 6Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 7Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 8Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 9Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 10Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 11Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 12Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 13Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 14Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 15Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 16Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 17Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 18Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 19
... DNA Engine Dyad instrument is the most ... Featuring MJ's world-class thermal performance, the Dyad ... as well as point-and-click navigation via touch ... can be easily and economically expanded to ...
...
...
...
Biology Products: