Navigation Links
Allergies and wheezing illnesses in childhood may be determined in the womb
Date:10/25/2010

A child's chances of developing allergies or wheezing is related to how he or she grew at vital stages in the womb, according to scientists from the University of Southampton.

The new research, funded by the Medical Research Council (MRC) and the British Lung Foundation, and undertaken at Southampton General Hospital, reveals that fetuses which develop quickly in early pregnancy but falter later in pregnancy are likely to go on to develop allergies and asthma as children. Scientists believe this is due to changes in the development of their immune system and lungs.

A fetus that grows too slowly in the womb is also more likely to become an infant who wheezes with common colds, possibly as a result of narrower airways in its lungs.

"Childhood allergies and asthma have become an epidemic in developed countries over the last 50 years. This research shows that in order to combat this, we need to understand more about how babies develop in the womb," comments Keith Godfrey, Professor of Epidemiology and Human Development at the University of Southampton and Deputy Director of the NIHR Nutrition Biomedical Research Unit at Southampton General Hospital.

"We already know that a baby's growth in the womb has an important influence on susceptibility to obesity and heart disease in later life, but this research provides some of the most direct evidence yet that changes in how the baby's immune system and lungs develops before birth can predispose them to some of the commonest childhood illnesses."

For the research, published in the Journal Thorax, University of Southampton scientists at the MRC Lifecourse Epidemiology Unit based at Southampton General Hospital studied more than 1,500 three year-old children who were taking part in the Southampton Women's Survey, the UK's largest study of women and their offspring. The Survey has studied how a woman's diet and lifestyle before and during pregnancy affects their baby's growth in the womb, and is monitoring how these early life influences determine health and development during childhood.

The team discovered evidence of sensitivity to common allergens (atopy) in 27 per cent of children who had developed quickly in early pregnancy but faltered later in pregnancy, as compared with 4 per cent in those with a slow early growth trajectory and quicker growth in late pregnancy.

Professor Stephen Holgate, from the Medical Research Council, says: "Unravelling the complex interplay between immunity and disease, over the course of a person's life, including before they are even born, is a core part of the MRC's research strategy. Furthering our understanding of the body's natural resilience is critical to developing new advances in the treatment of infectious diseases, autoimmune diseases and allergies."

Ian Jarrold, Research Manager at the British Lung Foundation, adds: "Children's lung health can be complex so this research, funded by the British Lung Foundation, is a considerable step forward in understanding why some children are more likely to develop allergies and asthma.

"The most commonly reported long-term illnesses in children and babies are conditions of the respiratory system. Increasing our understanding of childhood lung conditions is vital for developing new ways of diagnosing and treating lung diseases earlier in life."


'/>"/>

Contact: Sophie Docker
S.Docker@soton.ac.uk
44-238-059-8933
University of Southampton
Source:Eurekalert

Related biology news :

1. First study of its kind finds children with food allergies are often victims of bullying
2. Penn researchers identify immune cells that fight parasites may promote allergies and asthma
3. Preventing allergies
4. Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
5. Mites on hissing coackroach may benefit humans with allergies
6. Even natural perfumes may cause allergies
7. Food allergies: Overestimated and underestimated
8. Research finds new cause of ozone wheezing and potential treatments
9. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
10. University of the Basque Country develops system for identifying illnesses in Paraguay
11. Unexplained childhood disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/3/2016)... LONDON , June 3, 2016 /PRNewswire/ ... Transport Management) von Nepal ... ,Angebot und Lieferung hochsicherer geprägter Kennzeichen, einschließlich ... weltweit führend in der Produktion und Implementierung ... an der Ausschreibung im Januar teilgenommen, aber ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
Breaking Biology Technology: