Navigation Links
Allergies and wheezing illnesses in childhood may be determined in the womb
Date:10/25/2010

A child's chances of developing allergies or wheezing is related to how he or she grew at vital stages in the womb, according to scientists from the University of Southampton.

The new research, funded by the Medical Research Council (MRC) and the British Lung Foundation, and undertaken at Southampton General Hospital, reveals that fetuses which develop quickly in early pregnancy but falter later in pregnancy are likely to go on to develop allergies and asthma as children. Scientists believe this is due to changes in the development of their immune system and lungs.

A fetus that grows too slowly in the womb is also more likely to become an infant who wheezes with common colds, possibly as a result of narrower airways in its lungs.

"Childhood allergies and asthma have become an epidemic in developed countries over the last 50 years. This research shows that in order to combat this, we need to understand more about how babies develop in the womb," comments Keith Godfrey, Professor of Epidemiology and Human Development at the University of Southampton and Deputy Director of the NIHR Nutrition Biomedical Research Unit at Southampton General Hospital.

"We already know that a baby's growth in the womb has an important influence on susceptibility to obesity and heart disease in later life, but this research provides some of the most direct evidence yet that changes in how the baby's immune system and lungs develops before birth can predispose them to some of the commonest childhood illnesses."

For the research, published in the Journal Thorax, University of Southampton scientists at the MRC Lifecourse Epidemiology Unit based at Southampton General Hospital studied more than 1,500 three year-old children who were taking part in the Southampton Women's Survey, the UK's largest study of women and their offspring. The Survey has studied how a woman's diet and lifestyle before and during pregnancy affects their baby's growth in the womb, and is monitoring how these early life influences determine health and development during childhood.

The team discovered evidence of sensitivity to common allergens (atopy) in 27 per cent of children who had developed quickly in early pregnancy but faltered later in pregnancy, as compared with 4 per cent in those with a slow early growth trajectory and quicker growth in late pregnancy.

Professor Stephen Holgate, from the Medical Research Council, says: "Unravelling the complex interplay between immunity and disease, over the course of a person's life, including before they are even born, is a core part of the MRC's research strategy. Furthering our understanding of the body's natural resilience is critical to developing new advances in the treatment of infectious diseases, autoimmune diseases and allergies."

Ian Jarrold, Research Manager at the British Lung Foundation, adds: "Children's lung health can be complex so this research, funded by the British Lung Foundation, is a considerable step forward in understanding why some children are more likely to develop allergies and asthma.

"The most commonly reported long-term illnesses in children and babies are conditions of the respiratory system. Increasing our understanding of childhood lung conditions is vital for developing new ways of diagnosing and treating lung diseases earlier in life."


'/>"/>

Contact: Sophie Docker
S.Docker@soton.ac.uk
44-238-059-8933
University of Southampton
Source:Eurekalert

Related biology news :

1. First study of its kind finds children with food allergies are often victims of bullying
2. Penn researchers identify immune cells that fight parasites may promote allergies and asthma
3. Preventing allergies
4. Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
5. Mites on hissing coackroach may benefit humans with allergies
6. Even natural perfumes may cause allergies
7. Food allergies: Overestimated and underestimated
8. Research finds new cause of ozone wheezing and potential treatments
9. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
10. University of the Basque Country develops system for identifying illnesses in Paraguay
11. Unexplained childhood disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... JACKSONVILLE, Fla. , Feb. 2, 2017 /PRNewswire/ ... ), a clinical-stage immuno-oncology company specializing in the ... vaccines for the treatment of cancer and metastatic ... multi-gram scale-up and GMP manufacturing of a second ... T-cell vaccine targeting folate receptor alpha. The manufactured ...
(Date:2/2/2017)... , Feb. 1, 2017  Central to its ... meaningful advances worldwide, The Japan Prize Foundation today ... who have pushed the envelope in their respective ... Communication. Three scientists are being recognized with the ... that not only contribute to the advancement of ...
(Date:1/31/2017)... Jan. 31, 2017  Spero Therapeutics, LLC, a ... the treatment of bacterial infections, today announced it ... candidates from Pro Bono Bio Ltd (PBB) to ... multi-drug resistant forms of Gram-negative bacteria.   The assets ... Ltd, a PBB group company. "The ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... HACKENSACK, N.J. , Feb. 16, 2017  Champions ... engaged in the development and sale of advanced technology ... of oncology drugs, today announced the addition of new ... These new models will expand Champions, product ... cancer, head and neck cancer, AML, and non-small cell ...
(Date:2/16/2017)... and NEW YORK , Feb. 16, ... completion of their $7M Series B financing, adding an ... the $3.5M led by Mesa Verde Venture Partners and ... resources will be directed towards further accelerating commercial adoption ... comprehensive genomic profiling test and expanding the Paradigm cancer ...
(Date:2/15/2017)... , 15. Februar 2017  Trianni, Inc. ... Biotech, Inc. (Janssen) eine Lizenzvereinbarung über die Verwendung ... Klasse führenden Plattform für die Entdeckung monoklonaler Antikörper. ... ihr neuartiges chimäres Gensegmentdesign aus, das Janssen ... humanen Antikörpern bietet und das für die schelle ...
(Date:2/15/2017)... -- Windtree Therapeutics, Inc. (Nasdaq: WINT ), ... therapies for respiratory diseases, will host a conference call ... EST on Thursday, February 16, 2017 to provide updates ... announced closing of a $10.5 million private offering and ... in the live call and take part in the ...
Breaking Biology Technology: