Navigation Links
Allergies? Your sneeze is a biological response to the nose's 'blue screen of death'
Date:7/31/2012

Who would have thought that our noses and Microsoft Windows' infamous blue screen of death could have something in common? But that's the case being made by a new research report appearing online in The FASEB Journal (http://www.fasebj.org). Specifically, scientists now know exactly why we sneeze, what sneezing should accomplish, and what happens when sneezing does not work properly. Much like a temperamental computer, our noses require a "reboot" when overwhelmed, and this biological reboot is triggered by the pressure force of a sneeze. When a sneeze works properly, it resets the environment within nasal passages so "bad" particles breathed in through the nose can be trapped. The sneeze is accomplished by biochemical signals that regulate the beating of cilia (microscopic hairs) on the cells that line our nasal cavities.

"While sinusitis rarely leads to death, it has a tremendous impact on quality of life, with the majority of symptoms coming from poor clearance of mucus," said Noam A. Cohen, M.D., Ph.D., a researcher involved in the work from the Department of Otorhinolaryngology-Head and Neck Surgery at the University of Pennsylvania in Philadelphia. "By understanding the process by which patients with sinusitis do not clear mucus from their nose and sinuses, we can try to develop new strategies to compensate for their poor mucus clearance and improve their quality of life."

To make this discovery, Cohen and colleagues used cells from the noses of mice which were grown in incubators and measured how these cells cleared mucus. They examined how the cells responded to a simulated sneeze (puff of air) by analyzing the cells' biochemical responses. Some of the experiments were replicated in human sinus and nasal tissue removed from patients with and without sinusitis. They found that cells from patients with sinusitis do not respond to sneezes in the same manner as cells obtained from patients who do not have sinusitis. The researchers speculate that sinusitis patients sneeze more frequently because their sneezes fail to reset the nasal environment properly or are less efficient at doing so. Further understanding of why sinusitis patients have this difficulty could aid in the development of more effective medications or treatments.

"I'm confident that modern biochemical studies of ciliary beating frequency will help us find new treatments for chronic sinusitis," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "I'm far less confident in our abilities to resolve messy computer crashes. We now know why we sneeze. Computer crashes are likely to be a mystery forever."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Unraveling biological networks
2. New method for estimating parameters may boost biological models
3. A project to research biological and chemical aspects of microalgae to fuel approach
4. EPA to highlight innovative ways to detect and respond to biological threats
5. Salk scientists redraw the blueprint of the bodys biological clock
6. Weeding out invasive species with classical biological control
7. Crime and punishment: The neurobiological roots of modern justice
8. Electric charge disorder: A key to biological order?
9. Florida Tech biological sciences professor earns $257,000 NSF grant to study coral diseases
10. Like curry? New biological role identified for compound used in ancient medicine
11. Biological and Pharmaceutical Complex Fluids Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... , Aug. 15 2017   ivWatch LLC , a ... intravenous (IV) therapy, today announced receipt of its ISO 13485 Certification, ... by the International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early ... "This is an ...
(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... Proscia Inc ., a data ... titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, ... and how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
(Date:10/10/2017)... ... ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled a ... new look is part of a transformation to increase awareness, appeal to new markets ... It will also expand its service offering from its signature gourmet cooking classes and ...
Breaking Biology Technology: