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Allen Institute for Brain Science launches Allen Human Brain Atlas
Date:5/24/2010

on of individual genes in specific brain regions using in situ hybridization (ISH), a technique that provides images of where genes are expressed at high microscopic resolution and that was used for all earlier Allen Brain Atlas resources.

New data in this release include:

  • Whole Brain Microarray Survey: This "all genes, all structures" survey represents the largest component of this initial data release. It includes MRI, histology and microarray data from a single adult male control ("normal") brain, all integrated into a unified 3D framework. Specifically, the gene expression data include spatially mapped microarray data for over 700 distinct anatomic locations throughout the brain and containing information for over 62,000 gene probes with 93% of known genes represented by at least 2 probesin all, providing nearly 50 million gene expression measurements from a single brain. Data from brainstem and additional brains will be added in the future.

  • Subcortex Study: This ISH study characterizes 55 genes in subcortical regions extending from the front of the caudate through posterior substantia nigra, and a smaller set of 10 genes through the hypothalamus. The 55-gene set focuses on the glutamatergic and GABAergic systems. The 10-gene set includes useful markers for anatomic delineation.

In addition, existing data from what was previously available as the Allen Human Cortex Study have now been integrated into the Allen Human Brain Atlas. These data include:

  • 1,000 Gene Survey in Cortex: This ISH study characterizes approximately 1,000 genes in visual and temporal cortex of multiple control cases. Genes included in this dataset represent several categories of broad scientific and clinical interest: cortical cell type markers, gene families important to neural function, disease-related genes and genes important in the comparative genomics field.

  • Schizophrenia Study: This ISH study ex
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Contact: Aaron Blank
aaronblank@feareygroup.com
425-736-5456
Allen Institute for Brain Science
Source:Eurekalert

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