Navigation Links
Allen Institute for Brain Science launches Allen Human Brain Atlas
Date:5/24/2010

SEATTLE, Wash.May 24, 2010The Allen Institute for Brain Science announced today that it has launched the Allen Human Brain Atlas, a publicly available online atlas charting genes at work throughout the human brain. The data provided in this initial data release represent the most extensive and detailed body of information about gene activity in the human brain to date, documenting which genes are expressed, or "turned on" where. In the coming years, the Atlas will be expanded with more data and more sophisticated search, analysis and visualization tools to create a comprehensive resource useful to an increasingly wide range of scientists and research programs worldwide.

The Allen Human Brain Atlas, available at www.brain-map.org, is a unique multi-modal atlas of the human brain that integrates anatomic and genomic information to create a searchable, three-dimensional map of gene activity in the brain. Data modalities in this resource include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and histologyproviding information about gross neuroanatomy, pathways of neural connections, and microscopic anatomy, respectivelyas well as gene expression data derived from multiple approaches.

"The launch of the Allen Human Brain Atlas is a significant milestone for the Allen Institute," said Allan Jones, Ph.D., chief executive officer of the Allen Institute. "This is the largest and most challenging project we have undertaken to date, and after over two years of planning and nine months of data generation, we are delighted to now be able to get this first, significant dataset into the hands of the research community."

The data in this inaugural release provide both a broad survey of gene activity throughout the entire adult human brain using microarrays, in which the entire genome can be analyzed in a single experiment, as well as more focused cellular-resolution analyses of the expression of individual genes in specific brain regions using in situ hybridization (ISH), a technique that provides images of where genes are expressed at high microscopic resolution and that was used for all earlier Allen Brain Atlas resources.

New data in this release include:

  • Whole Brain Microarray Survey: This "all genes, all structures" survey represents the largest component of this initial data release. It includes MRI, histology and microarray data from a single adult male control ("normal") brain, all integrated into a unified 3D framework. Specifically, the gene expression data include spatially mapped microarray data for over 700 distinct anatomic locations throughout the brain and containing information for over 62,000 gene probes with 93% of known genes represented by at least 2 probesin all, providing nearly 50 million gene expression measurements from a single brain. Data from brainstem and additional brains will be added in the future.

  • Subcortex Study: This ISH study characterizes 55 genes in subcortical regions extending from the front of the caudate through posterior substantia nigra, and a smaller set of 10 genes through the hypothalamus. The 55-gene set focuses on the glutamatergic and GABAergic systems. The 10-gene set includes useful markers for anatomic delineation.

In addition, existing data from what was previously available as the Allen Human Cortex Study have now been integrated into the Allen Human Brain Atlas. These data include:

  • 1,000 Gene Survey in Cortex: This ISH study characterizes approximately 1,000 genes in visual and temporal cortex of multiple control cases. Genes included in this dataset represent several categories of broad scientific and clinical interest: cortical cell type markers, gene families important to neural function, disease-related genes and genes important in the comparative genomics field.

  • Schizophrenia Study: This ISH study examines 60 genes in a region of the cortex implicated in neuropsychiatric disordersthe dorsolateral prefrontal cortex (DLPFC)in over 50 control and schizophrenia (SCZ) cases. Genes covered in this dataset include cell-type markers, cortical layer-specific markers and SCZ candidate genes culled from the literature.


'/>"/>

Contact: Aaron Blank
aaronblank@feareygroup.com
425-736-5456
Allen Institute for Brain Science
Source:Eurekalert

Related biology news :

1. UNC researchers receive $100,000 Grand Challenges Exploration Grant to develop male contraceptive
2. Warmer summers could create challenges for nesting Arctic seabirds
3. Tackling the challenges of survival in a changing world
4. What is the grand challenge facing the future of agriculture?
5. George Daley to discuss challenges and opportunities facing stem cell scientists
6. Meeting tomorrows challenges: Start with science
7. Evolution impacts environment, challenging traditionally held view, UC Riverside study finds
8. DOE awards over a billion supercomputing hours to address scientific challenges
9. Water hits and sticks: Findings challenge a century of assumptions about soil hydrology
10. Fancier fakes: Makers of bogus prescription drugs pose new challenges
11. New report underlines multiple benefits but also new challenges to biodiversity-rich sites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... March 14, 2016 NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ... week of March 21 st .  The commercials will air ... popular Squawk on the Street show. --> NXTD ... growing mobile commerce market, announces the airing of a new ...
(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/9/2016)... March 9, 2016 This BCC Research report ... of the RNA Sequencing (RNA Seq) market for the ... instruments, tools and reagents, data analysis, and services. ... of the RNA-Sequencing market such as RNA-Sequencing tools and ... main factors affecting each segment and forecast their market ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Summit for Stem Cell has ... development of a patient-specific stem cell therapy for the treatment of Parkinson’s disease. The ... Jeanne Loring at The Scripps Research Institute in San Diego, CA. , ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... support for Connecticut's innovative, growing companies, today announced the launch of VentureClash ... technology (fintech) companies. , “VentureClash looks to attract the best early-stage ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... testing technology at the Spring 2016 Marijuana Business Conference and Expo. Shimadzu’s high-performance ... solvents, heavy metals, and more. Expo attendees can stop by booth 1021 to ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Board of ... appointment of John Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven from ... founding commercial leaders responsible for the commercialization of multiple orphan drug indications. ...
Breaking Biology Technology: