Navigation Links
Allen Institute for Brain Science announces first comprehensive gene map of the human brain
Date:4/12/2011

SEATTLE, Wash.April 12, 2011The Allen Institute for Brain Science has released the world's first anatomically and genomically comprehensive human brain map, a previously unthinkable feat made possible through leading-edge technology and more than four years of rigorous studies and documentation. The unprecedented mappings are the foundation for the Allen Human Brain Atlas, an online public resource developed to advance the Institute's goal to accelerate understanding of how the human brain works and fuel new discovery among the global research community.

In developing the Allen Human Brain Atlas, the Allen Institute has now thoroughly characterized and mapped the biochemistry of two normal adult human brains, providing opportunities for scientists to study the brain with new detail and accuracy. The data reveal a striking 94 percent similarity between human brains, establishing strong patterns as a critical foundation for translational and clinical research. In addition, data analysis from the two human brains indicate that at least 82 percent of all human genes are expressed in the brain, highlighting its tremendous complexity while also providing an essential genetic blueprint to understand brain functionality better and propel research in neurologic disease and other brain disorders.

Until now, a definitive map of the human brain, at this level of detail, simply hasnt existed, said Allan Jones, Ph.D., Chief Executive Officer of the Allen Institute for Brain Science. The Allen Human Brain Atlas provides never-before-seen views into our most complex and most important organ. Understanding how our genes are used in our brains will help scientists and the medical community better understand and discover new treatments for the full spectrum of brain diseases and disorders, from mental illness and drug addiction, to Alzheimers and Parkinsons diseases, multiple sclerosis, autism and more.

Similar to a high-powered, multi-functional GPS navigation system, the Allen Human Brain Atlas identifies 1,000 anatomical sites in the human brain, backed by more than100 million data points that indicate the particular gene expression and underlying biochemistry of each site. Scientists can use the Allen Human Brain Atlas to explore the human brain and identify how disease and trauma, including physical brain injuries and mental health disorders, affect specific areas of the brain. This powerful resource makes it possible to pinpoint where a particular drug acts anatomically in the brain, to ultimately better control the successful outcome of numerous therapies.

"The Allen Institute is a powerful force in modern science," said Dr. Edward Jones, neuroscientist at the University of California, Davis. "They've applied an industrialized approach and high-output technology to accomplish what no other lab has ever done. The original data produced for the mouse brain revolutionized neuroscience and now the Allen Human Brain Atlas delivers extremely rare and essential information that most researchers could not otherwise access. They are truly paving the way for the future of research."

The Allen Human Brain Atlas is free and available to scientists, physicians and the education community as an online public resource at www.brain-map.org.

Previously, as its inaugural initiative, the Allen Institute for Brain Science completed mappings of the adult mouse brain in 2006, similarly making the data available free to scientists. Overall, those data have led to a number of significant research advances around the world, including the publishing of over 500 peer-reviewed papers citing the Allen Mouse Brain Atlas to support research conclusions.

About the Allen Human Brain Atlas

A key aspect of the Atlas that makes it a powerful research tool is that it fully integrates several different kinds of data across different scales of brain exploration. Data incorporated into the Atlas include magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), as well as histology and gene expression data derived from both microarray and in situ hybridization (ISH) approaches.

Users of the Allen Human Brain Atlas comprise a diverse array of biomedical researchers primarily neuroscientists throughout the world. They include scientists who study the human brain itself, as well as those working in mouse and other model systems, providing a rare and important opportunity for them to probe the relevance of the findings to humans. Already, some 4,000 unique visitors are accessing the new Atlas each month.

It is anticipated that the Allen Human Brain Atlas will be used in small and large-scale applications to examine diseases and disorders, such as obesity, Parkinson's disease, autism, schizophrenia, Alzheimer's disease and multiple sclerosis as well as those exploring how the healthy brain works.

The Allen Institute for Brain Science will continue to expand the Allen Human Brain Atlas in the coming years, with new data from additional brains, as well as enhanced tools for searching, analyzing and viewing the data.


'/>"/>

Contact: Steven Cooper
steven.cooper@edelman.com
415-486-3264
Edelman PR
Source:Eurekalert

Related biology news :

1. Scientists Without Borders awards $10,000 to solvers of maternal health and nutrition challenge
2. BUSM faculty author commentary on the global challenges of emerging viral infections
3. Winners to share $1 million prize in Office of Naval Research challenge
4. Challenges for biofuels: New life cycle assessment report from Energy Biosciences Institute
5. IEEE-USA workshop to explore the challenges and opportunities of electric vehicle technology
6. Grants fund projects that will tackle Grand Challenges
7. Bee challenged -- toxin-laden nectar poses problems for honeybees
8. Freshwater sustainability challenges shared by Southwest and Southeast, researchers find
9. Reportlinker Adds Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
10. Could 135,000 laptops help solve the energy challenge?
11. First Allen Distinguished Investigators named
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/10/2017)... (PRWEB) , ... October 10, ... ... development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed ... targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces a presentation by ... Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present ...
Breaking Biology Technology: