Navigation Links
All eukaryotic kinases share 1 common set of substrates
Date:8/21/2007

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. Dysregulation of protein phosphorylation plays a major role in many diseases such as cancer and neurodegenerative disorders. In addition, the elucidation of many kinase cascades has proved pivotal for understanding and manipulating cellular behaviour in a variety of divergent eukaryotes.

Within these organisms a wide rage of kinases has been defined. The human genome contains over 500 protein kinase genes, whereas the genome of a small plant like Arabidopsis thaliana, the mouse-ear cress, contains nearly 1,000. Despite this diversity, a team led by Maikel Peppelenbosch, PhD, a professor of Cell Biology at the University Medical Center in Groningen, the Netherlands, has established that all eukaryotic kinases share a common set of substrates, nine amino acid segments shared by all proteins that are known to be phosphorylated.

The teams work is to be published in the online, open-access journal PLoS ONE on August 22nd.

Using a peptide array, the investigators tested all kinase substrates described in the PhosphoBase phosphorylation database. They incubated them with radio actively labelled ATP as a source of phosphate, and lysates (cell content) of two species of yeast (Candida albicans and Pichia pastoris), a fungus (Fusarium solani), a plant (Triticum aeastivum, wheat), a fruit fly (Drosophila melanogaster), a mouse (Mus musculus), and man (Homo sapiens) as a source of kinases. Their results show that the large diversity of kinases tested is contrasted by a very small diversity in the substrates that are sensitive to them.

These results indicate that, although probably thousands of different kinases have developed during the 2.4 billion years of eukaryotic evolution, they show no significant fun
'/>"/>

Contact: Professor Maikel Peppelenbosch
m.p.peppelenbosch@med.umcg.nl
Public Library of Science
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. Plants, animals share molecular growth mechanisms
3. Ancient olfaction protein is shared by many bugs, offering new pest control target
4. A new study examines how shared pathogens affect host populations
5. The lopsided brain: Attention bias is shared by humans and birds
6. A new way to share models of biological systems
7. Insects and mammals share common fat-building pathway, study suggests
8. Evolution mystery: Spider venom and bacteria share same toxin
9. More evidence mammals, fruit flies share make-up on function of biological clocks
10. Malaria, potato famine pathogen share surprising trait
11. Ocean seep mollusks may share evolutionary history with other deep-sea creatures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Frontiers in Plant Science , ... gene content and promoter evolution among grasses , ... of stretches of DNA that undergo little change in ... not code for any proteins. Some of these evolutionarily ... to regulate the expression of other genes or the ...
(Date:5/23/2013)... fruit, can be made both better-tasting and longer-lasting thanks ... "Working with GM tomatoes that are different to normal ... allows us to pinpoint exactly how to breed in ... Innes Centre. , The research could also lead to ... characteristics because even higher levels of the compounds can ...
(Date:5/23/2013)... Laboratory honored more than 165 staff for their ... PNNL,s annual Intellectual Property Commercialization Recognition & Rewards ... national laboratory named materials scientist Jun Liu Inventor ... materials that can store large amounts of energy, ... the time it takes to charge cell phones, ...
Breaking Biology News(10 mins):Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3The world's favorite fruit only better-tasting and longer-lasting 2PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2
... Institute, an NCI-designated cancer center at NYU Langone Medical ... Diffuse Large B-Cell Lymphoma (DLBCL), the most aggressive and ... published in the November 23 issue of Nature ... development of lymphomagenesis. "We have discovered that ...
... 28, 2011) -- Scientists at Weill Cornell Medical College used ... specially engineered for the study of cleft lip and cleft ... or treat the conditions in humans. Cleft lip and ... treatment requiring multiple cycles of surgery, speech therapy and orthodontics. ...
... published by Pensoft reported a substantial growth in 2011, ... jubilee 150th issue, By the end of November 2011, the ... compare with 4,962 pages and 180 articles in 2010). Since ... than 19,000 pages and 780 articles of valuable information on ...
Cached Biology News:New potential therapeutic target identified for Diffuse Large B-Cell Lymphoma 2Cleft lip corrected genetically in mouse model 2Cleft lip corrected genetically in mouse model 3Growth through innovations and open access: The journal ZooKeys on point for digital taxonomy 2
(Date:5/23/2013)... 24, 2013 Die Übersetzungen wurden ... Bei der englischen Version handelt es ... % der Teilnehmer einer groß angelegten Asthmaumfrage halten ihren ... GINA [*] -Definition [1] als kontrolliert gelten können ... generell einer von vier Denkweisen zugeordnet werden können, die ...
(Date:5/23/2013)... stopped breathing, his collapsed bronchus blocking the crucial flow ... watched helplessly, just praying that somehow the dire predictions ... had a good chance of not leaving the hospital ... Kaiba. "At that point, we were desperate. Anything that ... it." , They found hope at the University of ...
(Date:5/23/2013)... Colo. , May 23, 2013 Venaxis, ... diagnostic company focused on obtaining FDA clearance and commercializing ... today announced the pricing of an underwritten public offering ... warrants to purchase 3,500,000 shares of its common stock ... a combined public offering price of $1.25 per share ...
(Date:5/23/2013)... , May 23, 2013  BioScrip, Inc. (NASDAQ: ... will present at the Jefferies 2013 Global Healthcare Conference ... Hyatt New York. Richard Smith ... Hai Tran , Chief Financial Officer, will ... Eastern Daylight Time.   About BioScrip ...
Breaking Biology Technology:Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 2Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 3Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 4Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 5Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 6Neue Forschungsergebnisse zeigen Verbindung zwischen suboptimaler Asthmaversorgung und Patienteneinstellungen in Europa auf 7Baby's life saved with groundbreaking 3-D printed device that restored his breathing 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 3Venaxis Announces Pricing of Offering of Common Stock and Warrants 2Venaxis Announces Pricing of Offering of Common Stock and Warrants 3
... who have been dreaming of mobile devices that run ... wish has been granted. University of Illinois engineers ... is faster and uses 100 times less energy than ... devices much longer battery life between charges. Led ...
... Inc. (Nasdaq: MYL ) today announced that ... from the U.S. Food and Drug Administration (FDA) under ... its New Drug Application (NDA) for Zidovudine Tablets, 100 ... drug Retrovir® Tablets, by ViiV Healthcare. This pediatric antiretroviral ...
... (Nasdaq CM: INSMD), a biopharmaceutical company, today reported results ... 2010. Key Recent Highlights: ... 2011 with the FDA to begin a phase 3 ... non-TB Mycobacteria (NTM) lung infections. Successfully concluded 72 ...
Cached Biology Technology:New technology would dramatically extend battery life for mobile devices 2New technology would dramatically extend battery life for mobile devices 3Mylan's Matrix Receives FDA Approval Under PEPFAR for Zidovudine Tablets, 100 mg 2Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 2Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 3Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 4Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 5Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 6Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 7Insmed Announces Fourth Quarter and Full-Year 2010 Financial Results 8
... Pichia Protocols is the first all-inclusive ... the Pichia pastoris Expression System. Methods developed ... provided as detailed, step-by-step protocols. This book ... expression vector, through strain construction and analysis, ...
Rad 51C Immunogen: His-tagged human Rad 51C, over-expressed in E. coli Storage: 4 C...
...
...
Biology Products: