Navigation Links
All eukaryotic kinases share 1 common set of substrates
Date:8/21/2007

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. Dysregulation of protein phosphorylation plays a major role in many diseases such as cancer and neurodegenerative disorders. In addition, the elucidation of many kinase cascades has proved pivotal for understanding and manipulating cellular behaviour in a variety of divergent eukaryotes.

Within these organisms a wide rage of kinases has been defined. The human genome contains over 500 protein kinase genes, whereas the genome of a small plant like Arabidopsis thaliana, the mouse-ear cress, contains nearly 1,000. Despite this diversity, a team led by Maikel Peppelenbosch, PhD, a professor of Cell Biology at the University Medical Center in Groningen, the Netherlands, has established that all eukaryotic kinases share a common set of substrates, nine amino acid segments shared by all proteins that are known to be phosphorylated.

The teams work is to be published in the online, open-access journal PLoS ONE on August 22nd.

Using a peptide array, the investigators tested all kinase substrates described in the PhosphoBase phosphorylation database. They incubated them with radio actively labelled ATP as a source of phosphate, and lysates (cell content) of two species of yeast (Candida albicans and Pichia pastoris), a fungus (Fusarium solani), a plant (Triticum aeastivum, wheat), a fruit fly (Drosophila melanogaster), a mouse (Mus musculus), and man (Homo sapiens) as a source of kinases. Their results show that the large diversity of kinases tested is contrasted by a very small diversity in the substrates that are sensitive to them.

These results indicate that, although probably thousands of different kinases have developed during the 2.4 billion years of eukaryotic evolution, they show no significant fun
'/>"/>

Contact: Professor Maikel Peppelenbosch
m.p.peppelenbosch@med.umcg.nl
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. Plants, animals share molecular growth mechanisms
3. Ancient olfaction protein is shared by many bugs, offering new pest control target
4. A new study examines how shared pathogens affect host populations
5. The lopsided brain: Attention bias is shared by humans and birds
6. A new way to share models of biological systems
7. Insects and mammals share common fat-building pathway, study suggests
8. Evolution mystery: Spider venom and bacteria share same toxin
9. More evidence mammals, fruit flies share make-up on function of biological clocks
10. Malaria, potato famine pathogen share surprising trait
11. Ocean seep mollusks may share evolutionary history with other deep-sea creatures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014  Since its launch in December 2014, the 1U™ ... pain of trying to remember their usernames and passwords through ... their smartphones. To assist people who have struggled to remember ... created 1U and focuses on redefining identity, announced today that ...
(Date:12/19/2014)... Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ) has announced the ... Apple/AuthenTec TMDR92 & Sapphire - Technology Report" report ... Following the acquisition of AuthenTec in ... the iPhone 5S. It is currently the only device ...
(Date:12/17/2014)... DUBLIN , Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home Button ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first time ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... A team led by Penn State,s Ross Hardison, T. ... taken a large step toward unraveling how regulatory proteins ... growth. Working with collaborators including Drs. Mitchell Weiss and ... specifically on the complex process of producing red blood ...
... JOLLA, CA November 19, 2009 A team led by ... link between insulina hormone long associated with metabolism and metabolic ... has been conducted on insulin since its discovery in the ... connected to the fundamental process of temperature regulation. The ...
... While most of us would never willingly consume a ... plucking sushi from a bento box. New genetic detective work ... Museum of Natural History shows that bluefin tuna is routinely ... A quarter of what was labeled as tuna on sushi ...
Cached Biology News:New research into the mechanisms of gene regulation 2New research into the mechanisms of gene regulation 3New research into the mechanisms of gene regulation 4New research into the mechanisms of gene regulation 5Scripps research scientists find new link between insulin and core body temperature 2Scripps research scientists find new link between insulin and core body temperature 3Scripps research scientists find new link between insulin and core body temperature 4Unknowlingly consuming endangered tuna 2Unknowlingly consuming endangered tuna 3
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... December 23, 2014 According to Ross Selinger, ... Affiliate of ITRA Global, the national office market continues to ... This is evidenced by the third quarter’s surprising 3.9% ... Low energy costs have held inflation down and the ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. George ... for Reproductive Medicine (ASRM), a leading professional organization committed to ... new role as treasurer, Dr. Hill also fills a seat ... furthering the mission of ASRM. , Dr. Hill has ...
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... #HolidayInTheLab pictures for a chance to win pipette-themed gifts for ... think of a holiday gift for their beloved lab mates, ... holiday presents. The #HolidayInTheLab Contest encourages Pipette.com Twitter followers ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... An engineered metamaterial proved it can function as ... the electromagnetic spectrum, setting a standard of performance for ... of researchers from Boston College, the Los Alamos ... electrical current applied to the metamaterial a hybrid ...
... of MyMedicalRecords Pro to be Showcased For ... at HIMSS09LOS ANGELES, Feb. 24 MMR ... which through its wholly-owned operating subsidiary, MyMedicalRecords, ... Records ("PHRs") ( www.mymedicalrecords.com ) and electronic ...
... The European Commission has granted,marketing authorisation for ... the treatment of adult patients,with major depressive episodes. ... great scope for improved therapies to treat the,devastating ... Oxford, United Kingdom. "Valdoxan is an innovative, new ...
Cached Biology Technology:Team develops new metamaterial device 2Team develops new metamaterial device 3MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 2MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 3MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 4MMR Seeks Its Slice of the Billion-Dollar Stimulus Pie 5Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe 2Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe 3
... 8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) ... 8-isoprostane (8-iso PGF2α), in rabbits, monkeys ... PG-like product of non-specific lipid peroxidation. ... infused 8-isoprostane is converted primarily to ...
kismet (dK-20)...
...
Porcine Pulmonary Artery Endothelial Cells (PPAEC) (>500,000 cells)...
Biology Products: