Navigation Links
All eukaryotic kinases share 1 common set of substrates
Date:8/21/2007

Kinase mediated phosphorylation is generally recognised as the major regulator of virtually all metabolic activities in eukaryotic cells including proliferation, gene expression, motility, vesicular transport and programmed cell death. Dysregulation of protein phosphorylation plays a major role in many diseases such as cancer and neurodegenerative disorders. In addition, the elucidation of many kinase cascades has proved pivotal for understanding and manipulating cellular behaviour in a variety of divergent eukaryotes.

Within these organisms a wide rage of kinases has been defined. The human genome contains over 500 protein kinase genes, whereas the genome of a small plant like Arabidopsis thaliana, the mouse-ear cress, contains nearly 1,000. Despite this diversity, a team led by Maikel Peppelenbosch, PhD, a professor of Cell Biology at the University Medical Center in Groningen, the Netherlands, has established that all eukaryotic kinases share a common set of substrates, nine amino acid segments shared by all proteins that are known to be phosphorylated.

The teams work is to be published in the online, open-access journal PLoS ONE on August 22nd.

Using a peptide array, the investigators tested all kinase substrates described in the PhosphoBase phosphorylation database. They incubated them with radio actively labelled ATP as a source of phosphate, and lysates (cell content) of two species of yeast (Candida albicans and Pichia pastoris), a fungus (Fusarium solani), a plant (Triticum aeastivum, wheat), a fruit fly (Drosophila melanogaster), a mouse (Mus musculus), and man (Homo sapiens) as a source of kinases. Their results show that the large diversity of kinases tested is contrasted by a very small diversity in the substrates that are sensitive to them.

These results indicate that, although probably thousands of different kinases have developed during the 2.4 billion years of eukaryotic evolution, they show no significant fun
'/>"/>

Contact: Professor Maikel Peppelenbosch
m.p.peppelenbosch@med.umcg.nl
Public Library of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. Plants, animals share molecular growth mechanisms
3. Ancient olfaction protein is shared by many bugs, offering new pest control target
4. A new study examines how shared pathogens affect host populations
5. The lopsided brain: Attention bias is shared by humans and birds
6. A new way to share models of biological systems
7. Insects and mammals share common fat-building pathway, study suggests
8. Evolution mystery: Spider venom and bacteria share same toxin
9. More evidence mammals, fruit flies share make-up on function of biological clocks
10. Malaria, potato famine pathogen share surprising trait
11. Ocean seep mollusks may share evolutionary history with other deep-sea creatures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Spanish researchers have detected an unknown interaction between microorganisms ... introduced into a droplet of salt water and is ... to create biomineralogical biosaline 3D morphologically complex formations, where ... are revived. The discovery was made by chance with ... the Astrobiology journal and may help to ...
(Date:7/24/2014)... sobering examples of how wildlife loss leads to conflict ... by Wildlife Conservation Society (WCS) Health & Ecosystems: ... calls for an interdisciplinary approach to tackle global biodiversity ... about 15% of the world,s people and provides protein ... It should come as no surprise that today,s unprecedented ...
(Date:7/24/2014)... 2014) Scientists at The New York Stem ... closer to creating a viable cell replacement therapy ... , For the first time, NYSCF scientists ... skin samples of patients with primary progressive multiple ... to induce these stem cells into becoming oligodendrocytes, ...
Breaking Biology News(10 mins):Bacteria manipulate salt to build shelters to hibernate 2New study draws links between wildlife loss and social conflicts 2NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2
... One of the remaining challenges for evolutionary developmental studies ... teeth, is how their tooth shape is altered during ... their Japanese colleagues from the University of Kioto now ... of tooth shape features called cusps. Position and shape ...
... a new detailed map of the three-dimensional terrain of ... critical for communication in the brain and nervous system. ... resolved at nanometer scale, or one-billionth of a meter, ... of the synaptic landscape. , Using the map as ...
... When it comes to the deadly skin cancer ... may better provide insight into the disease's development, ... Medical Institute predoctoral fellow at Stanford University School ... associated with melanoma development, scientists have not been ...
Cached Biology News:Mechanism regulating tooth shape formulation found 2The synapse is a shotgun 2The synapse is a shotgun 3Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance 2Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance 3
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... prefer to settle into equilibriuma state of unchanging ... realm of non-equilibrium conditions where new possibilities lie. ... phases, such as temperature fluctuations, freezing and melting, ... their body temperature, airplanes to fly, and the ... But even though these conditions exist naturally and ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 ... seven-year contract with the National Institute of Allergy and ... Health, to conduct preclinical development of potential therapies for ... of drugs to treat HIV and AIDS and the ... well as microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... faculty members will explore energy from the ocean, manufacturing ... to prestigious Faculty Early Career Development (CAREER) Awards from ... million over five years, went to assistant professors Yannis ... and Wheeler Ruml of the computer science department. ...
... Calif., Feb. 21, 2012  Life Technologies Corporation (NASDAQ: ... Barclays Capital Global Healthcare Conference on Wednesday, March 14 ... Vice President and Chief Financial Officer, will present on ... presentation, which will be available for three weeks following ...
... leaders from the medical community in Europe and the U.S. ... liver disease and sepsis, and in cardiac surgery, during ... "Albumin in Clinical Fluid Management ." (Logo: ... a frank and provocative exchange about the uses and effectiveness ...
Cached Biology Technology:NSF CAREER grants support ocean energy, microforming, computer planning 2Life Technologies to Present at Barclays Capital Global Healthcare Conference 2Medical Experts Who Participated in CSL Behring's Key Issues Dialogue Prefer Albumin for Fluid Management 2Medical Experts Who Participated in CSL Behring's Key Issues Dialogue Prefer Albumin for Fluid Management 3
Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Dendritic Cells...
...
...
Biology Products: