Navigation Links
Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics'
Date:4/1/2009

Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Dr. Shilatifard's publication appeared today in Genes and Development and resulted from a meeting on December 7-10, 2008 that he co-organized at Cold Spring Harbor Laboratory in New York to discuss aspects of epigenetic control in genomic function and to develop a consensus definition of "epigenetics" for consideration by the broader research community.

The definition is intended to address confusion within the scientific community about the distinction between the mechanisms of epigenetic memory during early development versus those of dynamic chromatin regulation involved in differential expression of genes throughout adult life. The mechanisms underlying epigenetic memory are of great importance to human development and disease, but they are poorly understood.

The proposed definition reads: "an epigenetic trait is a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence." Shilatifard and colleagues have also proposed three categories of signals that operate in the establishment of a stably heritable epigenetic state. The first is a signal from the environment, the second is a responding signal in the cell that specifies the affected chromosomal location, and the third is a sustaining signal that perpetuates the chromatin change in subsequent generations.

"The field of 'epigenetics' has been an exciting one and has grown swiftly over the past several years, extending well beyond an initial discovery phase and identification of fundamental non-genetic and chromatin-based regulatory mechanisms," said Dr. Shilatifard. "This collective effort to define and discuss 'epigenetics' is an attempt to add focus and clarity to this exciting and growing area of research."


'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
2. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
3. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
4. CSHL scientists clarify editing error underlying genetic neurodegenerative disease
5. Study helps clarify role of soil microbes in global warming
6. UCLA researchers clarify function of glucose transport molecule
7. Scientists clarify a mechanism of epigenetic inheritance
8. Purdue researchers obtain a snapshot clarifying how materials enter cells
9. The epigenetics of increasing weight through the generations
10. Environmental epigenetics has potential for preventing and treating disease
11. UD leads $5.3-million research project on rice epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , June 23, 2016 Houston Methodist ... the Cy-Fair Sports Association to serve as their ... agreement, Houston Methodist Willowbrook will provide sponsorship support, ... connectivity with association coaches, volunteers, athletes and families. ... the Cy-Fair Sports Association and to bring Houston ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: