Navigation Links
Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics'
Date:4/1/2009

Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Dr. Shilatifard's publication appeared today in Genes and Development and resulted from a meeting on December 7-10, 2008 that he co-organized at Cold Spring Harbor Laboratory in New York to discuss aspects of epigenetic control in genomic function and to develop a consensus definition of "epigenetics" for consideration by the broader research community.

The definition is intended to address confusion within the scientific community about the distinction between the mechanisms of epigenetic memory during early development versus those of dynamic chromatin regulation involved in differential expression of genes throughout adult life. The mechanisms underlying epigenetic memory are of great importance to human development and disease, but they are poorly understood.

The proposed definition reads: "an epigenetic trait is a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence." Shilatifard and colleagues have also proposed three categories of signals that operate in the establishment of a stably heritable epigenetic state. The first is a signal from the environment, the second is a responding signal in the cell that specifies the affected chromosomal location, and the third is a sustaining signal that perpetuates the chromatin change in subsequent generations.

"The field of 'epigenetics' has been an exciting one and has grown swiftly over the past several years, extending well beyond an initial discovery phase and identification of fundamental non-genetic and chromatin-based regulatory mechanisms," said Dr. Shilatifard. "This collective effort to define and discuss 'epigenetics' is an attempt to add focus and clarity to this exciting and growing area of research."


'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
2. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
3. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
4. CSHL scientists clarify editing error underlying genetic neurodegenerative disease
5. Study helps clarify role of soil microbes in global warming
6. UCLA researchers clarify function of glucose transport molecule
7. Scientists clarify a mechanism of epigenetic inheritance
8. Purdue researchers obtain a snapshot clarifying how materials enter cells
9. The epigenetics of increasing weight through the generations
10. Environmental epigenetics has potential for preventing and treating disease
11. UD leads $5.3-million research project on rice epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2017)... Feb. 2, 2017  EyeLock LLC, a market leader ... white paper " What You Should Know About Biometrics ... ensuring user authenticity is a growing concern. In traditional ... users. However, traditional authentication schemes such as username/password suffer ... Biometric authentication offers an elegant solution to the problem ...
(Date:1/30/2017)... Jan. 30, 2017   Invitae Corporation (NYSE: ... genetic information companies, today announced that it will report ... provide 2017 guidance on Monday, February 13, 2017, and ... day at 4:45 p.m. Eastern / 1:45 p.m. Pacific. ... will briefly review financial results, guidance, and recent developments ...
(Date:1/24/2017)... Biopharm Reports has carried out a ... nuclear magnetic resonance spectroscopy (NMR). This involved the ... practices, developments, trends and end-user plans over the ... opportunities. These areas include growth in the use ... innovation requirements, hyphenated NMR techniques, main suppliers of ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... -- Champions Oncology, Inc. (NASDAQ: CSBR ), a ... technology solutions and products to personalize the development and ... new cohorts of PDX models to their existing TumorBank. ... product line in hepatocellular cancer, breast cancer, castrate resistant ... cell lung cancer (including EGFR mutation; ALK/ROS1 positive) PDX ...
(Date:2/16/2017)... Feb. 16, 2017  Windtree Therapeutics, Inc. (Nasdaq: ... on developing aerosolized KL4 surfactant therapies for respiratory ... influenza study showed that aerosolized KL4 surfactant reduced ... well-established preclinical animal model. The Company believes that ... of evidence that supports the role of KL4 ...
(Date:2/16/2017)... , Feb. 16, 2017 Paradigm Diagnostics ... B financing, adding an additional $3M from New Sciences ... Verde Venture Partners and other strategic partners at the ... further accelerating commercial adoption of their flagship Paradigm Cancer ... expanding the Paradigm cancer registry. Dr. ...
(Date:2/15/2017)... ... February 15, 2017 , ... Executive search firm, ... Officer with GenePeeks. Matt is a veteran life sciences and molecular diagnostics ... company focused on identifying inherited disease risk in future generations. In his new ...
Breaking Biology Technology: