Navigation Links
Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics'

Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Dr. Shilatifard's publication appeared today in Genes and Development and resulted from a meeting on December 7-10, 2008 that he co-organized at Cold Spring Harbor Laboratory in New York to discuss aspects of epigenetic control in genomic function and to develop a consensus definition of "epigenetics" for consideration by the broader research community.

The definition is intended to address confusion within the scientific community about the distinction between the mechanisms of epigenetic memory during early development versus those of dynamic chromatin regulation involved in differential expression of genes throughout adult life. The mechanisms underlying epigenetic memory are of great importance to human development and disease, but they are poorly understood.

The proposed definition reads: "an epigenetic trait is a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence." Shilatifard and colleagues have also proposed three categories of signals that operate in the establishment of a stably heritable epigenetic state. The first is a signal from the environment, the second is a responding signal in the cell that specifies the affected chromosomal location, and the third is a sustaining signal that perpetuates the chromatin change in subsequent generations.

"The field of 'epigenetics' has been an exciting one and has grown swiftly over the past several years, extending well beyond an initial discovery phase and identification of fundamental non-genetic and chromatin-based regulatory mechanisms," said Dr. Shilatifard. "This collective effort to define and discuss 'epigenetics' is an attempt to add focus and clarity to this exciting and growing area of research."


Contact: Marie Jennings
Stowers Institute for Medical Research

Related biology news :

1. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
2. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
3. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
4. CSHL scientists clarify editing error underlying genetic neurodegenerative disease
5. Study helps clarify role of soil microbes in global warming
6. UCLA researchers clarify function of glucose transport molecule
7. Scientists clarify a mechanism of epigenetic inheritance
8. Purdue researchers obtain a snapshot clarifying how materials enter cells
9. The epigenetics of increasing weight through the generations
10. Environmental epigenetics has potential for preventing and treating disease
11. UD leads $5.3-million research project on rice epigenetics
Post Your Comments:
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
(Date:10/26/2015)... 2015  Delta ID Inc., a company focused on ... PC devices, announced its ActiveIRIS® technology powers the iris ... launched by NTT DOCOMO, INC in Japan ... smartphone to include iris recognition technology, after a very ... in May 2015, world,s first smartphone to have this ...
(Date:10/22/2015)...  Synaptics (NASDAQ: SYNA ), a leading developer of human ... September 30, 2015. --> --> ... 66 percent over the comparable quarter last year to $470.0 million. ... million, or $0.62 per diluted share. --> ... of fiscal 2016 grew 39 percent over the prior year period ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... International Society for ... of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The conference ... ISPE hosted the largest number of attendees in more than a decade. ...
(Date:11/24/2015)... , ... November 24, 2015 , ... The Academy of ... Interest Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the First–Person ... few years. Many AMA members have embraced this type of racing and several new ...
(Date:11/24/2015)... FRANCISCO , Nov. 24, 2015  Twist ... announced that Emily Leproust, Ph.D., Twist Bioscience chief ... Jaffray Healthcare Conference on December 1, 2015 at ... Hotel in New York City. --> ... . Twist Bioscience is on Twitter. ...
(Date:11/24/2015)... , Nov. 24, 2015 Capricor Therapeutics, ... focused on the discovery, development and commercialization of first-in-class ... Chief Executive Officer, is scheduled to present at the ... at 10:50 a.m. EST, at The Lotte New York ... . . --> ...
Breaking Biology Technology: