Navigation Links
Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics'
Date:4/1/2009

Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence.

Dr. Shilatifard's publication appeared today in Genes and Development and resulted from a meeting on December 7-10, 2008 that he co-organized at Cold Spring Harbor Laboratory in New York to discuss aspects of epigenetic control in genomic function and to develop a consensus definition of "epigenetics" for consideration by the broader research community.

The definition is intended to address confusion within the scientific community about the distinction between the mechanisms of epigenetic memory during early development versus those of dynamic chromatin regulation involved in differential expression of genes throughout adult life. The mechanisms underlying epigenetic memory are of great importance to human development and disease, but they are poorly understood.

The proposed definition reads: "an epigenetic trait is a stably inherited phenotype resulting from changes in a chromosome without alterations in the DNA sequence." Shilatifard and colleagues have also proposed three categories of signals that operate in the establishment of a stably heritable epigenetic state. The first is a signal from the environment, the second is a responding signal in the cell that specifies the affected chromosomal location, and the third is a sustaining signal that perpetuates the chromatin change in subsequent generations.

"The field of 'epigenetics' has been an exciting one and has grown swiftly over the past several years, extending well beyond an initial discovery phase and identification of fundamental non-genetic and chromatin-based regulatory mechanisms," said Dr. Shilatifard. "This collective effort to define and discuss 'epigenetics' is an attempt to add focus and clarity to this exciting and growing area of research."


'/>"/>

Contact: Marie Jennings
mfj@stowers.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
2. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
3. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
4. CSHL scientists clarify editing error underlying genetic neurodegenerative disease
5. Study helps clarify role of soil microbes in global warming
6. UCLA researchers clarify function of glucose transport molecule
7. Scientists clarify a mechanism of epigenetic inheritance
8. Purdue researchers obtain a snapshot clarifying how materials enter cells
9. The epigenetics of increasing weight through the generations
10. Environmental epigenetics has potential for preventing and treating disease
11. UD leads $5.3-million research project on rice epigenetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... City, Missouri (PRWEB) , ... May 27, 2016 , ... ... Development Manager, Turf and Ornamental Products. , In his 15-year career with PBI-Gordon, Dave ... Herbicide Product Manager, where he was integral in the development and launch of many ...
(Date:5/27/2016)... NEW YORK , May 27, 2016 ... state, but investors playing in this space know that volatility ... this morning,s featured companies on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: ... CTIC ), Lpath Inc. (NASDAQ: LPTN ), and ... now and gain access to the technical alerts for these ...
(Date:5/26/2016)... , May 26, 2016 Q BioMed ... it will be a featured presenter at the 5th Annual ... New York City at the Grand Hyatt ... , Q BioMed Inc. CEO, is scheduled to begin at ... the company,s business strategy, recent developments and outline milestones for ...
(Date:5/26/2016)... ... 26, 2016 , ... Kinder Scientific (KinderScientific.com), a leading animal ... the Company for the future. Kinder Scientific announces restructured ownership and additional ... appointed Chairman of the Board, Curtis D. Kinghorn has been appointed CEO/President and ...
Breaking Biology Technology: