Navigation Links
'Alert status' area in brain discoved by Hebrew University scientists

Jerusalem, Sept. 14, 2009 -- A new understanding of how anesthesia and anesthesia-like states are controlled in the brain opens the door to possible new future treatments of various states of loss of consciousness, such as reversible coma, according to Hebrew University of Jerusalem scientists.

In an article published in the Journal of Neuroscience, the scientists, Marshall Devor, the Cecile and Seymour Alpert Professor of Pain Research, graduate student Ruth Abulafia and research associate Dr. Vladimir Zalkind describe their discovery of an area of the brain that participates in the control of "alert status."

Loss of response to painful stimuli and loss of consciousness are the most striking characteristics of surgical anesthesia and anesthesia-like states, such as concussion, reversible coma, and syncope (fainting). These states also exhibit behavioral suppression, loss of muscle tone, a shift to the sleep-like "delta-wave" EEG pattern, and depressed brain metabolism.

It has been widely presumed that this constellation of dramatic functional changes reflects widely distributed suppression of neuronal activity in the brain due to dispersed drug action, or to global oxygen or nutrient starvation.

However, new results revealed by the Hebrew University scientists suggest a radically different architecture -- that a small group of neurons near the base of the brain, in the mesopontine tegmentum, has executive control over the alert status of the entire cerebrum and spinal cord, and can generate loss of pain sensation, postural collapse and loss of consciousness through specific neural circuitry.

This conclusion derives from the observation that microinjection of tiny quantities of certain anesthetic drugs into this newly discovered "center of consciousness" in laboratory rats induced a profound suppressive effect on the activity of the cerebral cortex.

It is not certain that these results will translate reliably from rats to man. But if they do, there are at least two implications of considerable interest. First, this knowledge could contribute to the ability of medical science to treat disorders of consciousness and its loss, such as insomnia, excessive sleepiness and even coma. Perhaps by direct electrical stimulation of the cells in question, it might prove possible to arouse a patient from coma.

Second, the discovery of a specific cluster of neurons that control the brain's state of consciousness can be expected to lead to the beginnings of an understanding of the actual wiring diagram that permits a biological machine, the brain, to be conscious.


Contact: Jerry Barach
The Hebrew University of Jerusalem

Related biology news :

1. Intruder alert: Tel Aviv Universitys Smart Dew will find you!
2. Red alert! How disease disables tomato plants intruder alarm
3. BIO-key(R) Announces Emergency Alert and Management Solutions for Schools and Campuses
4. Sunburn alert: UVB does more damage to DNA than UVA
5. AMBER Alert Safety Centers to Provide Child Safety Precautions at the New Jersey State Fair at the Meadowlands
6. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
7. Irritating smells alert special cells, NIH-funded study finds
8. Telemedicine: Health alert via satellite
9. Alcohol and sleep restriction can affect young mens alertness and driving performance
10. Enzyme alerts cells powerful army to repair DNA damage
11. Hypertension among lower-status employees lingers well into retirement
Post Your Comments:
Related Image:
'Alert status' area in brain discoved by Hebrew University scientists
(Date:5/16/2017)... --  Bridge Patient Portal , an enterprise patient ... Systems , an electronic medical record solutions developer ... a partnership to build an interface between the ... products, including Centricity Practice Solution (CPS), Centricity Business ... integrations will allow healthcare delivery networks using GE ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at . 2016 Year ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... States multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® ... identifying clinically significant acute bacterial and viral respiratory tract infections by testing ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... NJ (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic ... one eye at a time. So which eye do you rinse first if a dangerous ... have Plum Duo Eye Wash with its unique dual eye piece. , “Whether ...
(Date:10/11/2017)... 11, 2017  VMS BioMarketing, a leading provider of patient ... Clinical Nurse Educator (CNE) network, which will launch this week. ... among health care professionals to enhance the patient care experience ... and other health care professionals to help women who have ... ...
Breaking Biology Technology: