Navigation Links
Alcohol consumption can cause too much cell death, fetal abnormalities
Date:8/25/2008

The initial signs of fetal alcohol syndrome are slight but classic: facial malformations such as a flat and high upper lip, small eye openings and a short nose.

Researchers want to know if those facial clues can help them figure out how much alcohol it takes during what point in development to cause these and other lifelong problems.

They have good evidence that just a few glasses of wine over an hour in the first few weeks of fetal life, typically before a woman knows she's pregnant, increases cell death. Too few cells are then left to properly form the face and possibly the brain and spinal cord.

"It's well known that when you drink, you get a buzz. But a couple of hours later, that initial impact, at least, is gone," says Dr. Erhard Bieberich, biochemist in the Medical College of Georgia Schools of Medicine and Graduate Studies. "But, your fetus may have experienced irreversible damage."

He thinks the damage results from the death of neural crest cells, versatile cells that travel a lot during development, ultimately helping form bone, cartilage, connective tissue, the heart and more. These cells are developing at the same time as neural tube cells that form the brain and spinal cord. Consequently, the telltale facial abnormalities in a newborn also may foretell problems with learning, memory, vision, hearing and more.

Some cells need to die during development. "There is always a very delicate balance between newly formed cells and dying cells," says Dr. Bieberich. "It's a very active period of that balance, because usually you develop a surplus of tissue then later melt it back down to acquire a specific shape." He likes to use the hands as an example of critical melting. "The digits form because the inter-digital tissue dies. If it did not die, we would have paddles instead of hands with fingers."

Cell death likely results from alcohol disturbing the metabolism of the lipids that help the hollow wad of stem cells that forms in the first day of life find direction and purpose, he says.

A grant from the March of Dimes, whose mission is to prevent birth defects and infant mortality, is enabling him to compare cell loss in mice following different levels of alcohol consumption to the usual loss that occurs in development.

His focus is these neural crest cells, which help form the upper part of the skull. Some neural crest cells stay in the brain and, early on, these cells share growth factors with neural tube cells. Cognitive and other brain damage is hard to quantify this early, but mice missing the neural crest gene also experience problems with skull and brain development.

Ideally his measurements will give women a better idea of the risk of alcohol consumption and point toward a way to reduce the damage. "You have to make people aware of the science behind the risk," Dr. Bieberich says. "We are not saying that every pregnant woman who drinks three or four glasses of wine in a short period will have a baby with birth defects, but it elevates the risk."


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Researchers block damage to fetal brain following maternal alcohol consumption
2. Alcohol binges early in pregnancy increase risk of infant oral clefts
3. MicroRNA implicated as molecular factor in alcohol tolerance
4. Alcohol is associated with risk of perennial allergic rhinitis
5. Survey of Hispanics and alcohol dependence
6. Your babys brain on drugs (and alcohol and tobacco)
7. Alcohol and malt liquor availability and promotion higher in African American inner cities
8. Study suggests new way to screen infants for fetal alcohol syndrome
9. Learning how to say no to alcohol advertising and peer pressure works for inner-city adolescents
10. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
11. Cognitive, genetic clues identified in imaging study of alcohol addiction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Alcohol consumption can cause too much cell death, fetal abnormalities
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... enabling healthier lives through the development of innovative products ... the United States denied its ... the claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 ... criteria established by the Supreme Court,s Mayo Collaborative Services ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of ... their brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been ... Target to its list of well-respected retailers. This list includes such fine stores ...
Breaking Biology Technology: