Navigation Links
Alcohol binges early in pregnancy increase risk of infant oral clefts
Date:7/31/2008

A new study by researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts.

The researchers found that women who consumed an average of five or more drinks per sitting were more than twice as likely than non-drinkers to have an infant with either of the two major infant oral clefts: cleft lip with or without cleft palate, or cleft palate alone. Women who drank at this level on three or more occasions during the first trimester were three times as likely to have infants born with oral clefts.

"These findings reinforce the fact that women should not drink alcohol during pregnancy," said Lisa A. DeRoo, Ph.D., an epidemiologist at NIEHS and author on the study. "Prenatal exposure to alcohol, especially excessive amounts at one time, can adversely affect the fetus and may increase the risk of infant clefts." The causes of clefts are largely unknown, but both genetic predisposition and environmental factors are believed to play a role in their development. The paper appears online today as an advance access publication in the American Journal of Epidemiology.

The population-based study was conducted in Norway, which has one of the highest rates of oral clefts in Europe. The investigators contacted all families of newborn infants born with clefts between 1996 and 2002. The study included 573 mothers who had babies born with cleft lip with or without cleft palate and cleft palate only; as well as 763 mothers randomly selected from all live births in Norway. The average age of the mostly married mothers was 29 years.

Mothers completed a self-administered mailed questionnaire focused heavily on the mother's lifestyle and environmental exposures during her first three months of pregnancy when a baby's facial development takes place.

The researchers found increased risks of orofacial clefts among infants whose mothers reported binge-level drinking of an average of five or more drinks per occasion during the first-trimester compared to non-drinkers. Risk was further increased among women who drank at this level most frequently.

Both animal and human data suggest that it is the dose of alcohol consumed at one time during pregnancy rather than the frequency or total amount over time that matters most. "The greater the blood alcohol concentration, the longer the fetus is exposed. A single binge during a critical period of an infant's development can be harmful," said DeRoo.

"Fortunately, heavy maternal drinking is uncommon in many populations, but the fact that it is happening at all tells us we need to do a better job of letting mothers know about the effects that alcohol can have on their baby's development," said Allen J. Wilcox, M.D., Ph.D., NIEHS researcher and co-author on the paper. In Norway, a separate study found that 25 percent of Norwegian women reported at least one binge drinking episode early during pregnancy.

Alcohol is a recognized teratogen, or an environmental agent that can cause malformations of an embryo or fetus. One of the most severe outcomes of heavy maternal drinking is fetal alcohol syndrome, a lifelong condition that causes physical and mental disabilities, including craniofacial malformations. There has been little research to determine if alcohol consumption is related to oral cleft risk.


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Related biology news :

1. MicroRNA implicated as molecular factor in alcohol tolerance
2. Alcohol is associated with risk of perennial allergic rhinitis
3. Survey of Hispanics and alcohol dependence
4. Your babys brain on drugs (and alcohol and tobacco)
5. Alcohol and malt liquor availability and promotion higher in African American inner cities
6. Study suggests new way to screen infants for fetal alcohol syndrome
7. Learning how to say no to alcohol advertising and peer pressure works for inner-city adolescents
8. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
9. Cognitive, genetic clues identified in imaging study of alcohol addiction
10. A research of the UGR shows the genetic predisposition to develop alcohol abuse
11. Research reveals secrets of alcohols effect on brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2016)... SuperCom (NASDAQ:   SPCB ... e-Government, Public Safety, HealthCare, and Finance sectors announced today that Leaders ... to implement and deploy a community-based supportive services program to reduce ... , further expanding its presence in the state. ... This new program, which is expected ...
(Date:12/16/2016)...   IdentyTechSolutions America LLC , a leading ... and a cutting-edge manufacturer of software and hardware ... seamless, integrated solutions that comprise IDT biometric readers ... provide IdentyTech,s customers with combined physical identification and ... and theft. "We are proud to ...
(Date:12/15/2016)... , Dec. 15, 2016   WaferGen Bio-systems, ... held genomics technology company, announced today that on December ... Qualifications Department of The Nasdaq Stock Market LLC which ... bid price of WaferGen,s common stock had been at ... WaferGen has regained compliance with Listing Rule 5550(a)(2) of ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017  Protagonist Therapeutics, Inc. ... it has initiated a global Phase 2b induction ... peptide that targets alpha4beta7 integrin. The aim of ... to evaluate the safety/tolerability and efficacy of PTG-100 ... moderate to severe active disease. ...
(Date:1/16/2017)... ... January 16, 2017 , ... Attagene , a Research ... U.S. Small Business Administration. The Tibbetts Award honors the Small Business Innovation ... and are considered the best of the best from the thousands of firms ...
(Date:1/13/2017)... -- Research and Markets has announced the addition of ... to 2021" report to their offering. ... The biosimilars market is expected to ... 2016, at a CAGR of 26.3%. The global ... and application. Factors such as rising incidence of various diseases, increasing ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... teamed up with several companies to offer its customers three new solutions for ... probe would come in handy if a customer has an oddly-shaped sample that ...
Breaking Biology Technology: