Navigation Links
Air pollution exposure affects chances of developing premenopausal breast cancer
Date:4/20/2011

BUFFALO, NY -- Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown.

The findings indicated that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment and assuring healthy tissues.

Methylation is a chemical process that has been implicated in determining which genes in a cell are active, a process essential to normal cellular function.

Women with breast cancer who lived in a region with more air pollution were more likely to have the alteration in the DNA in their tumor than those who lived in a less-polluted region, results showed.

Higher air pollution concentration at the time of first child birth also was associated with changes in p16, a gene involved in tumor suppression, according to findings.

Results of the research were presented April 6 at the 2011 American Association for Cancer Research annual meeting in Orlando, Fla.

Lead investigator Katharine Dobson, MPH, an epidemiology doctoral student and research assistant in UB's Department of Social and Preventive Medicine, says of the findings: "To our knowledge, this is the first study to examine exposure to ambient air pollution at key points in a woman's lifetime.

"The investigation looked for an association between exposure to pollution and alterations to DNA that influence the presence or absence of key proteins. Such genetic changes are thought to be major contributors to cancer development and progression, including at very early stages," Dobson says.

The study is based on data from the Western New York Exposures and Breast Cancer (WEB) study, which collected information from 1,170 women with recently diagnosed breast cancer and 2,116 healthy women who lived in New York's Erie and Niagara counties between 1996 and 2001. This research involved only cancer cases.

Participants provided information on where they were born, where they lived at the time of their first menstrual period, and, if they had children, where they lived when they bore their first child. Data from air monitors operating in the relevant time periods was used to determine the amount of particulate matter at each participant's residence at those time periods. Air pollution data from 87 sites in Western New York was matched with residence location at year of birth, year of menarche and year of first child birth.

"We found that decreased E-cadherin promoter methylation was associated with higher exposure at birth, and increased p16 methylation with higher exposure at the time of a first child birth," says Dobson.

"For breast cancer cases, menopausal status appeared to modify the association between air pollution exposure and E-cadherin promoter methylation, with premenopausal women more susceptible to these early exposures than postmenopausal women."

More research is needed to determine the role of air pollution in DNA methylation in breast cancer development and progression, and to address changing air pollution contents and levels over time, Dobson notes.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert

Related biology news :

1. Latest report on North American industrial pollution reveals impacts on our shared water environment
2. Cephalopods experience massive acoustic trauma from noise pollution in the oceans
3. Study: Emissions trading doesnt cause pollution hot spots
4. The dark side of spring? Pollution in our melting snow
5. Pinpointing air pollutions effects on the heart
6. Hold your breath: Air pollution plays role in cardiac, metabolic diseases
7. Protecting ecosystems, pollution remediation goals of research at UH
8. Pollution with antibiotics leads to resistant bacteria
9. Pollution tax rebates little help for low-income workers
10. University of Miami scientists find new way to estimate global rainfall and track ocean pollution
11. Morning-after spike in ozone air pollution from Super Bowl XLV?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... N.C. , Dec. 6, 2016 Valencell ... announced today it has seen a third consecutive year ... biometric sensor technology in 2016 with a 360 percent ... last year. This increase was driven by sales of ... as robust interest in its technology for hearables for ...
(Date:11/30/2016)... 30, 2016 Not many of us realize that we spend ? of ... we need to do it well. Inadequate sleep levels have been found to lead ... diabetes, and even cancer. Maybe now is the best time to rethink ... them to manage their sleep quality? Continue Reading ... ...
(Date:11/28/2016)... "The biometric system market ... The biometric system market is in the growth stage ... future. The biometric system market is expected to be ... CAGR of 16.79% between 2016 and 2022. Government initiative ... in smartphones, rising use of biometric technology in financial ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... ... Partners ("GPP") portfolio company, today announced it has acquired the assets of ... of Chiltern International and focuses on clinical trial drug packaging, labeling, storage, ...
(Date:12/6/2016)... MENLO PARK, Calif. , Dec. 6, 2016 ... of up to $150 million from the National ... Infectious Diseases and the Division of AIDS (NIAID-DAIDS) ... microbicides and other non-vaccine pre-exposure (PreP) agents. Under ... suite of preclinical product development services for candidate ...
(Date:12/5/2016)... 5, 2016 Axovant Sciences Ltd. (NYSE: ... on the treatment of dementia, today announced that data ... of Alzheimer,s disease will be presented at the 2016 ... December 9, 2016 in San Diego ... both simple and complex measures of activities of daily ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... soon resume cervical and lumbar disc production, company President, Jake Lubinski will be ... are implanting the AxioMed disc in Cologne and Karlsruhe to discuss the benefits ...
Breaking Biology Technology: