Navigation Links
Aging impacts epigenome in human skeletal muscle
Date:11/20/2013

Our epigenome is a set of chemical switches that turn parts of our genome off and on at strategic times and locations. These switches help alter the way our cells act and are impacted by environmental factors including diet, exercise and stress. Research at the Buck Institute reveals that aging also effects the epigenome in human skeletal muscle. The study, appearing on line in Aging Cell, provides a method to study sarcopenia, the degenerative loss of muscle mass that begins in middle age.

The results came from the first genome-wide DNA methylation study in disease-free individuals. DNA methylation involves the addition of a methyl group to the DNA and is involved in a particular layer of epigenetic regulation and genome maintenance. In this study researchers compared DNA methylation in samples of skeletal muscle taken from healthy young (18 - 27 years of age) and older (68 89 years of age) males. Buck faculty and lead scientist Simon Melov, PhD, said researchers looked at more than 480,000 sites throughout the genome. "We identified a suite of epigenetic markers that completely separated the younger from the older individuals there was a change in the epigenetic fingerprint," said Melov. "Our findings were statistically significant; the chances of that happening are infinitesimal."

Melov said scientists identified about six-thousand sites throughout the genome that were differentially methylated with age and that some of those sites are associated with genes that regulate activity at the neuromuscular junction which connects the nervous system to our muscles. "It's long been suspected that atrophy at this junction is a weak link in sarcopenia, the loss of muscle mass we get with age," said Melov. "Maybe this differential methylation causes it. We don't know."

Studying the root causes and development of sarcopenia in humans is problematic; the research would require repeated muscle biopsies taken over time, something that would be hard to collect. Melov says now that the epigenetic markers have been identified in humans, the goal would be to manipulate those sites in laboratory animals. "We would be able to observe function over time and potentially use drugs to alter the rate of DNA methylation at those sites," he said. Melov says changes in DNA methylation are very common in cancer and that the process is more tightly controlled in younger people.


'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
Buck Institute for Age Research
Source:Eurekalert

Related biology news :

1. NIH grant funds multi-center study of mysterious trauma-induced hemorrhaging
2. Visualizing the past: Nondestructive imaging of ancient fossils
3. Research reveals roles for exercise and diet in aging, depression
4. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
5. Experimental drug reduces brain damage, eliminates brain hemorrhaging in rodents afflicted by stroke
6. Cancer imaging centers get £35 million boost
7. Extremely rare mitochondrial DNA deletions associated with aging can be accurately detected with Droplet Digital PCR
8. Statins may slow human aging by protecting against telomere shortening: A feature of senescent cells
9. A mothers genes influence her childs aging
10. Major study links aging gene to blood cancer
11. Rapamycin: Limited anti-aging effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... 20, 2017 Research and Markets has announced ... report to their offering. ... The global voice recognition biometrics market to grow ... The report covers the present scenario and the growth prospects ... the market size, the report considers the revenue generated from the ...
(Date:1/19/2017)... CLARA, Calif. , Jan. 19, 2017 /PRNewswire/ ... company enhancing user experience and security for consumer ... of next-generation payment processing systems and cybersecurity solutions, ... more banks, enterprises and financial institutions worldwide to ... part of the end-to-end secure user authentication platforms ...
(Date:1/18/2017)... MedNet Solutions , an innovative ... spectrum of clinical research, is proud to announce ... the organization in terms of corporate growth, outside ... and services. The company,s exceptional achievements can be ... iMedNet ™ – MedNet,s ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... 2017 According to a ... (Consumables, Service), Type (Safety, Efficacy, Validation), Disease Indication ... and Development, Disease-Risk) - Global Forecast to 2021" ... reach USD 53.34 Billion by 2021 from USD ... of 13.8% during the forecast period (2016-2021). ...
(Date:2/17/2017)... MILPITAS, Calif. , Feb. 17, 2017 /PRNewswire/ ... posters detailing data on its oral peptide drug ... Congress of the European Crohn,s and Colitis ... in Barcelona, Spain from ... The posters detail preclinical data on Protagonist drug ...
(Date:2/16/2017)... and GREENWICH, Conn. ... private investment firm focused on venture growth investments ... promotion of Josh Richardson , M.D. to ... investments in biotechnology companies.  He is a board ... important roles in Longitude,s investments in Aimmune Therapeutics, ...
(Date:2/16/2017)... , Feb. 16, 2017   Capricor ... a clinical-stage biotechnology company developing first-in-class biological therapies ... that it has elected to terminate its license ... peptide receptor agonists, including Cenderitide. "Our ... move as we prioritize our efforts to advance ...
Breaking Biology Technology: