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Aging gracefully requires taking out the trash
Date:12/14/2007

rmal part of the aging process, says Simonsen, but most importantly they demonstrate that enhancing the clearance of damaged proteins and protein aggregates increases longevity.

Insulin signaling and caloric restriction are two major determinants of longevity and they also impact the activity level of autophagy. Therefore, regulating autophagy, the pathway that directly does the cleanup work, may be the key factor in controlling the aging process, the researchers say. By maintaining the expression of a rate-limiting autophagy gene in the aging nervous system there is a dramatic extension of lifespan and resistance to age-associated oxidative stress, says Finley.


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Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100 x1340
Salk Institute  
Source:Eurekalert

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