Navigation Links
Aging brains are different in humans and chimpanzees
Date:7/27/2011

Brains shrink in humans, potentially causing a number of health problems and mental illnesses as people age, but do they shrink to the same extent in the closest living relatives to humans--the chimpanzees?

New research says no, making the extreme amount of brain shrinkage resulting from normal aging in humans unique.

Chet Sherwood, an anthropologist at The George Washington University in Washington, D.C., and a team of scientists from seven other U.S. universities put forward the question to see if comparable data on the effects of aging could be found in chimpanzees. Such data on regional brain volumes in chimpanzees was not available, until now.

The researchers--anthropologists, neuroscientists, psychologists, biologists, and veterinary professionals--used magnetic resonance imaging (MRI) to measure the space occupied by various brain structures in adult humans and chimpanzees, including the frontal lobe and the hippocampus, an area of the brain associated with short-term and long-term memory.

They found chimpanzees do not display significant loss, or atrophy, in the size of their brains and other internal structures as they age.

Instead, Sherwood and colleagues suggest that as humans evolved the ability to live longer, the result was a "high degree of brain degeneration" as people get older.

"We were most surprised that chimpanzees, who are separated from humans by only 6-8 million years of independent evolution, did not more closely resemble the human pattern of brain aging," said Sherwood. "It was already known that macaque monkeys, separated from humans by about 30 million years, do not show humanlike, widespread brain atrophy in aging."

The current issue of Proceedings of the National Academy of Sciences reports the findings. The National Science Foundation (NSF) partially funded the research.

Because humans and chimpanzees grow, develop and age on different schedules, the study compared humans from age 22 to 88 and chimpanzees from age 10 to 51. For both species, this encompassed the whole adult lifespan under natural conditions. Humans have a longer lifespan than chimpanzees. In the wild, the lifespan of chimpanzees is about 45 at the oldest. With medical care in captivity, they can live into their 60s. On the other hand, humans without access to modern medical care and who live in traditional hunter-gatherer societies can live to their mid-80s.

The researchers used MRI to measure the volume of the whole brain, total neocortical gray matter, total neocortical white matter, frontal lobe gray matter, frontal lobe white matter and the hippocampus in a cross-sectional sample of 99 chimpanzees and 87 adult humans.

"Traits that distinguish humans from other primates include enlargement of the brain and increased longevity," they write in the report "Aging of the Cerebral Cortex Differs Between Humans and Chimpanzees."

Consequently, they say, humans are unique among animals in being susceptible to certain neuropathologies, such as Alzheimer's disease, in the later stages of life. Even in the absence of disease, however, healthy aging in humans is marked by variable degrees of neural deterioration and cognitive impairment.

"This is an excellent example of research that has implications for societal benefits," said NSF Physical Anthropology Program Officer Kaye Reed. "While Dr. Sherwood and colleagues are interested in the evolutionary significance of brain differences between chimpanzees and humans, the results of this research can be used as a basis to explore degenerative brain diseases, such as Alzheimer's, in a medical context."

"This research points to the uniqueness of how severe brain aging is in humans," said Sherwood. "While there are certainly many similarities between humans and other animals in the degenerative processes that occur in the brain, our research indicates that even healthy, normal aging in humans involves more pronounced brain deterioration than in other species.

"Taken together with particular environmental and genetic risk factors, this might help to explain the fact that only humans are vulnerable to developing dementing illnesses like Alzheimer's disease in old age."

Sherwood and colleagues conclude evolution led to both a large brain and a long lifespan in humans. They point out that the benefits of these traits are much debated, but they surmise it might be related to an increased reliance on social learning of skills.

"As a result, we suggest that the high energy cost of a large brain in humans leads to more wear and tear that cannot be easily repaired because most neurons are not renewed," said Sherwood. "As a consequence, human brains become more vulnerable to degeneration towards the later stages of life."


'/>"/>

Contact: Bobbie Mixon
bmixon@nsf.gov
703-292-8070
National Science Foundation
Source:Eurekalert  

Related biology news :

1. Harmful effects of hypothyroidism on maternal and fetal health drive new guidelines for managing thyroid disease in pregnancy
2. Cutting-edge imaging techniques for neuroscientists available in latest laboratory manual
3. Faster 3-D nanoimaging a possibility with full color synchrotron light
4. Premature aging caused by some HIV drugs, study shows
5. Imaging cereals for increased crop yields
6. Using recycled cardboard in food packaging risks contaminating food with mineral oils
7. TGen Drug Development partners with Imaging Endpoints for comprehensive clinical trial services
8. Super-mini vehicles carry therapeutics and imaging agents into body with mega results
9. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
10. Managing forests requires a birds-eye view
11. New nanoscale imaging may lead to new treatments for multiple sclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging brains are different in humans and chimpanzees
(Date:11/30/2016)... -- higi SH llc (higi) announced today the launch ... industry thought-leaders and celebrity influencers looking to encourage, ... steps to live healthier, more active lives. ... built the largest self-screening health station network in ... have conducted over 185 million biometric screenings.  The ...
(Date:11/29/2016)... Nearly one billion matches per second with DERMALOG,s high-speed AFIS    ... ... DERMALOG is Germany's largest Multi-Biometric supplier: The ... Identification Systems) ... Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System is part of ...
(Date:11/22/2016)... November 22, 2016 According to the new market ... Print, Face, Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact ... MarketsandMarkets, the market is expected to grow from USD 10.74 Billion in ... 16.79% between 2016 and 2022. Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... CARDIFF, UK (PRWEB) , ... December 08, 2016 ... ... high precision light to control cells — optogenetics — is key to exciting ... state of the art, spatially patterned light projected via free-space optics stimulates small, ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... data bioInformatics portal. In response to client demand KbioBox developed a sophisticated “3 ... biodesign program. Both are accessible from KBioBox’s new website, https://www.kbiobox.com/ ...
(Date:12/8/2016)... 8, 2016 Soligenix, Inc. (OTCQB: SNGX) (Soligenix ... developing and commercializing products to treat rare diseases where ... it will be hosting an Investor Webcast Event Friday, ... origins of innate defense regulators (IDRs) as a new ... mucositis and the recently announced and published Phase 2 ...
(Date:12/8/2016)... Dec. 8, 2016   Biocept, Inc . ... provider of clinically actionable liquid biopsy tests to ... clinical data featuring its Target Selector™ Circulating Tumor ... for the detection of actionable biomarkers in patients ... sponsored by Sara Cannon Research Institute (SCRI), the ...
Breaking Biology Technology: