Navigation Links
After decades of research, scientists unlock how insulin interacts with cells
Date:1/9/2013

The discovery of insulin nearly a century ago changed diabetes from a death sentence to a chronic disease.

Today a team that includes researchers from Case Western Reserve University School of Medicine announced a discovery that could lead to dramatic improvements in the lives of people managing diabetes.

After decades of speculation about exactly how insulin interacts with cells, the international group of scientists finally found a definitive answer: in an article published today in the journal Nature, the group describes how insulin binds to the cell to allow the cell to transform sugar into energyand also how the insulin itself changes shape as a result of this connection.

"These findings carry profound implications for diabetes patients," said Case Western Reserve biochemistry professor and department chair Michael A. Weiss, MD, PhD, MBA, one of the leaders of the team. "This new information increases exponentially the chances that we can develop better treatmentsin particular, oral medications instead of syringes, pens or pumps."

Weiss, also the Cowan-Blum Professor of Cancer Research at the School of Medicine, is renowned worldwide for his work on insulin. In 1991 he used nuclear magnetic resonance techniques to describe the structure of insulin; more recently he has developed a preliminary version of the hormone that does not need to be refrigerated, a critical breakthrough for those with diabetes in the developing world.

The results published today, however, represent among the most promising for Weiss and an entire generation of scientists devoted to enhancing care for those suffering from diabetes. They have sought to solve mystery of how the hormone bound to cells since 1969, when the late Dorothy Hodgkin and colleagues at the University of Oxford, first described insulin's structure.

"There's been a logjam in our understanding since then," Weiss said. "We hope that we've broken the logjam
'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cognitive deficits from concussions still present after 2 months
2. Ups and downs of biodiversity after mass extinction
3. Research pinpoints key gene for regenerating cells after heart attack
4. UofL scientist uncovers how airway cells regenerate after chlorine gas injury
5. Leukemia patients remain in remission more than 2 years after engineered T cell therapy
6. Microbial missing link discovered after man impales hand on tree branch
7. After 121 years, identification of grave robber fossil solves a paleontological enigma
8. New injectable gels toughen up after entering the body
9. Neurons made from stem cells drive brain activity after transplantation in laboratory model
10. Bone marrow stem cells do not improve short-term recovery after heart attack
11. After long-ago mass extinction, global warming hindered species recovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... this summer and some of the smoke from those fires ... collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard the ... has descended over the Great Lakes region of the United ... from July 23, 2014 (first image feature highlighted below) clearly ... southeastward. In the image, it is over Manitoba and ...
(Date:7/25/2014)... healthcare community and remain priority areas that ... the worldwide crisis of obesity and diabetes, ... in diabetes, epidemiology and public health describe ... of diverse intervention programs in this novel ... on "Global Health Perspectives in Prediabetes and ...
(Date:7/25/2014)... girls reach puberty is influenced by ,imprinted genes,a subset of ... gene. This is the first evidence that imprinted genes ... of this study were published today in the journal ... menarche, is a marker for the timing of puberty in ... varies between girls, is an inherited trait, and is linked ...
Breaking Biology News(10 mins):What constitutes an effective response to the global 'diabesity' tsunami? 2Could age of first period influence development of diseases in older women? 2
... Four new reservoirs linked to rice cultivation built in the ... the 1990,s have allowed various migratory dabbling duck species to ... University of Extremadura propose that Vegas Altas del Guadiana is ... Many aquatic migratory bird populations are in decline and the ...
... even the most intelligent, complex brains can be taken by a ... it was false. When the brain fires up the network ... used for analysis, a pivotal study led by a Case Western ... blind to the public relations fiasco his cost-cutting decision has made? ...
... has given new clues as to how some E. coli ... slightly different transmission strategies, with some being better adapted to live ... of food poisoning due to contamination of vegetables by dangerous strains ... making sure our food remains safe., E. coli is most ...
Cached Biology News:Ducks flock to Extremadura thanks to its ricefields 2Ducks flock to Extremadura thanks to its ricefields 3Empathy represses analytic thought, and vice versa 2Empathy represses analytic thought, and vice versa 3Empathy represses analytic thought, and vice versa 4Empathy represses analytic thought, and vice versa 5E. coli adapts to colonize plants 2
(Date:7/25/2014)... , July 25, 2014  Galmed Pharmaceuticals Ltd. ... company focused on the development and commercialization of a ... and cholesterol gallstones, today announced financial results for the ... 2014 Financial Summary: , Reported cash and cash ... with $137,000 at December 31, 2013.  , Reported ...
(Date:7/25/2014)... 25, 2014 At the request of ... a 60-day extension for the public comment period (Docket ... for Model Aircraft established by Congress as part of ... 60-day extension establishes the new deadline for comments as ... of Transportation/FAA notice published in the Federal Register on ...
(Date:7/24/2014)... July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the ... randomized, active control Phase 3 study of Zerenex (ferric ... for the treatment of hyperphosphatemia in patients with end-stage ... binding and iRon delivery with FErric CiTrate in EsrD) ... the American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 Gain ... Global Supply Chain of the biotech industry. Nominations ... Innovation Awards, brought to you by the ... organization of supply chain management professionals for the ... to stakeholders of the Biotech industry – Manufacturers, ...
Breaking Biology Technology:Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6FAA Grants Comment Extension at the Request of AMA 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3
... Md., March 27 Local biotechnology leader,MedImmune ... student Yiwei Li,has received the distinguished "MedImmune ... ScienceMONTGOMERY project. The company sponsored the,Montgomery County ... year and presented the award to recognize ...
... - IntelliPharmaCeutics Ltd. (Delaware),is pleased to announce ... trial for its new abuse-resistant, alcohol-resistant once-a-day,oral ... of Toronto ("IntelliPharmaCeutics" or the "Company"). The ... its novel ReXista(TM) abuse and,alcohol resistant drug ...
... (Nasdaq: PRXL ) today announced that it ... pharmacology business of,Synchron Research in Ahmedabad, India. The ... in Poitiers, France to a subsidiary of,Synchron, SYNEXEL ... new agreement, PAREXEL,s ownership interest in,the Ahmedabad Phase ...
Cached Biology Technology:Seneca Valley High School Student Receives Science Award From MedImmune 2Seneca Valley High School Student Receives Science Award From MedImmune 3IntelliPharmaCeutics Announces Successful Completion of a Pilot Clinical Trial for its Abuse and Alcohol Resistant Sustained Release Oxycodone 2IntelliPharmaCeutics Announces Successful Completion of a Pilot Clinical Trial for its Abuse and Alcohol Resistant Sustained Release Oxycodone 3PAREXEL International Expands Relationship with Synchron Research in India and Divests Bioanalytical Laboratory in France 2PAREXEL International Expands Relationship with Synchron Research in India and Divests Bioanalytical Laboratory in France 3PAREXEL International Expands Relationship with Synchron Research in India and Divests Bioanalytical Laboratory in France 4
RNA oligomers from 10 to 50 bases purified by PAGE and MS-checked. RNAs are supplied dried and fully deprotected....
... The iEMS Incubator/Shaker HT is ... the iEMS Incubator/Shaker HT is ... DNA hybridization and primer extension ... is available as a one-cabinet ...
... Anti-Reverse Cap Analog (ARCA) is a ... OH group (closer to m7G) is replaced ... RNA polymerase can only initiate transcription with ... incorporation in the forward orientation. As a ...
...
Biology Products: