Navigation Links
Advances reported in quest for drugs targeting childhood cancer
Date:3/29/2010

umors feature extra copies of the MDMX gene as do nearly 20 percent of patients with breast, colon and lung cancer.

The finding expands on work from Dyer's laboratory into the genetic and biochemical missteps that give rise to retinoblastoma. The advance reflects the combined efforts of the St. Jude departments of Developmental Neurobiology; Chemical Biology and Therapeutics; and Structural Biology. The first authors are Damon Reed, M.D., formerly of St. Jude and now of St. Petersburg, Fla., and Ying Shen, Ph.D., of Developmental Neurobiology.

"We went from a discovery in childhood cancer, MDMX amplification, to characterizing this first inhibitor in about three-and one-half years," Dyer said. "This model is now being replicated over and over in other cancers we treat at St. Jude."

Dyer's laboratory developed the biochemical and cell-based tests used by colleagues in Chemical Biology and Therapeutics. Researchers checked a chemical library of nearly 300,000 compounds using high-throughput screening. Investigators searched for molecules likely to block MDMX activity.

Dyer said the new compound might help researchers studying the biology of MDMX. "It may also be useful for any tumor that has normal p53," he said. "The idea is that if you have normal p53 and you need to turn it on, maybe by giving a drug that hits MDM2 and another that hits MDMX; you free p53 up to kill the cell."

Investigators' predictions of exactly how SJ-172550 interacts with MDMX are based on mathematical and computer models. Work is underway to capture an X-ray crystal structure of SJ-172550 bound to MDMX.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
2. Cardiologists and heart surgeons meet for Controversies and Advances conference
3. Lockheed Martin Advances Biometrics Portfolio Through Cooperation Agreement With Cognitec
4. Genetic Engineering & Biotechnology News reports on advances in miRNA
5. Prototype terahertz imager promises biochem advances
6. Science expands Science Signaling, featuring research related to medical advances, and more
7. Analysis of RNA role in spreading disease advances study of damaging plant infections
8. Iowa State-ConocoPhillips collaboration advances 26 research projects in first year
9. Brown to host conference on advances in neurotechnology
10. Latest advances in interventional cardiology for congenital heart disease presented
11. Advances in the field of schizophrenia research: New genetic factors identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Advances reported in quest for drugs targeting childhood cancer
(Date:9/2/2014)... the September issue of The FASEB Journal ... to diagnose the leading cause of blindness in ... occurred. This advance involves quantifying the early molecular ... retinal vessels. Using new probes developed by scientists, ... development of diabetic retinopathy. , "My goal is ...
(Date:9/2/2014)... Washington D.C., September 2, 2014 A study ... Journal of the American Academy of Child ... adolescents diagnosed with a psychiatric diagnosis had an ... exposed to antipsychotics. , Using data from the ... by Dr. Ren Ernst Nielsen, Psychiatry, Aalborg University ...
(Date:9/2/2014)... Konservat-Lagersttte of lithographic limestone is well known as ... from that area (for example, Archaeopteryx). Now, for ... in the French equivalent of these outcrops - ... oldest known water treader. , Despite the abundance ... fossils have been obtained from the Late Kimmeridgian ...
Breaking Biology News(10 mins):Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2
... provide the next generation of human therapeutic drugs. , ... by Queensland University of Technology PhD researcher Liam St ... and major trauma. , The genetic code for the ... researcher Liam St Pierre from QUT's School of Life ...
... of the brain when small stones are scattered on the ... researchers at UC Davis. The brains of those young fish ... and the fish also showed behavior closer to wild than ... hatchery and the wild fish," said graduate student Rebecca Kihslinger, ...
... the bilateral body axes in animals as diverse as flies ... in patterning an animal with a different body plan--a simple ... jellyfish, are members of the phylum Cnidaria, and they possess ... bilateral body plan exhibited by vertebrates and many other animals. ...
Cached Biology News:Taipan venom no snake oil 2How to grow a bigger brain 2Anemone genes reveal versatile building blocks for body plans 2
(Date:9/2/2014)... , September 2, 2014 Culot ... research and lab management services  BioData, producer ... is pleased to announce the appointment of Louis ... recently served as VP Marketing and Business Development at ... research and clinical applications. Previously, Culot worked ...
(Date:9/1/2014)... 2014 Reportlinker.com announces that a new ... India Solid Waste Management Vehicles Market ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In India ... bodies responsible for complete handling and regulation of ... around 135,000 MT solid waste is generated daily ...
(Date:9/1/2014)... The Collaborative R&D Terms and ... comprehensive understanding and unprecedented access to the collaborative ... worlds leading life science companies. , The report ... and why companies enter collaborative R&D deals. , ... deals terms provides critical insight into the negotiation ...
(Date:8/31/2014)... Available spectra is similar for all L-series ... of a wide range of plants. The spectra ... patented and pending wide spectrum technology. The single ... applications in contrast to growth spectra made from ... a large variety of differently sized and shaped ...
Breaking Biology Technology:Louis Culot Appointed as BioData's CEO 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4
... 29 NOMAD Bioscience GmbH,Munich, Germany ... developing,plant-made biomaterials and biopharmaceuticals that address ... series of high-value products such as,nanopatterned ... and,enzymes for important markets including biofuels, ...
... Cooperation with Kentucky Bioprocessing for future-oriented technology, ... 29 Bayer,Innovation GmbH and Kentucky Bioprocessing, ... at KBP,s Owensboro plant in the US ... biopharmaceuticals. Based on Bayer,s proprietary,magnICON(R) technology, plant ...
... Sept. 29 Covance Inc. (NYSE:,CVD) announced today ... joint venture,with WuXi Pharmatech to provide preclinical contract ... become an attractive region for outsourced drug,development services ... pursue our original strategy to build our own ...
Cached Biology Technology:Nomad Bioscience: New Plant Biotechnology Company Founded to Focus on Biomaterials and Biopharmaceuticals 2Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 2Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 3Bayer Broadens Its Manufacturing Basis for Biopharmaceuticals in Tobacco Plants 4Covance Decides to Pursue Its Original Preclinical Strategy in China 2
... is for when you need to make your ... transformation efficiency. Our services for preparing competent cells ... MCLab's custom competent cell service offers: ... Fast turnaround Quality control performance ...
Fast, sensitive quantitation of total MEK 1/2 concentration....
Argon Calibration Source...
RayBio Human Chemokine Antibody Array 1.1 (8) with Accessory, detects 38 chemokine factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: