Navigation Links
Advances in personalized medicine for lung cancer
Date:4/18/2012

RRM2 levels was 36.5 months compared to 46.1 months for those with low RRM2 levels."

"This is the first study that identifies RRM2 expression as a negative prognostic factor in resected stage I-III NSCLC," they report.

"RRM2 was identified as an unfavorable prognostic marker in our study population and this is in agreement with its crucial role in supplying deoxyribonucleotides for DNA synthesis and repair and with the finding that cells overexpressing RRM2 exhibit enhanced cellular invasiveness," Dr Dal Bello explained.

Because of the high and rapid recurrence rate of lung cancer, prognostic markers to identify patients with higher risk of relapse represent a high unmet medical need. "The prognostic role of RRM2 can help to identify patients at higher risk of relapse who may benefit from adjuvant chemotherapy," she noted.

Epigenetic clues distinguish tumor types

Dr David Shames from a San Francisco, Californiabased biotechnology company[1] and colleagues report that epithelial-like lung tumors, which have a better prognosis and exhibit greater sensitivity to inhibitors of the EGFR pathway, can be distinguished from mesenchymal-like tumors on the basis of global DNA methylation patterns.

DNA methylation is an important form of 'epigenetic' modification, which affects the expression of genes within cells.

Using cancer cell lines and surgically resected non-small cell lung cancer tumors, the researchers showed that patterns of DNA methylation can divide non-small cell lung cancer into two phenotypically distinct subtypes.

Their work also provides proof of principle, they say, that "differences in DNA methylation can be used as a platform for predictive biomarker discovery and development."

A promising biomarker of response to radiotherapy

In a further report, Dr Ioannis Trigonis from the Wolfson Molecular Imaging Centre and The Christie Hospital in Manchester, UK,
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Annual Bibliography of Significant Advances in Dietary Supplement Research 2007
2. New book includes advances in the science and practice of transfusion and transplantation
3. State fund advances titanium powder research, 9 other Iowa State projects
4. Evolution and climate change research advances at Rutgers-Camden
5. Iowa Power Fund advances researcher’s long quest for efficient solar power
6. Salient Stills Notches Significant Advances in Profitability, Diversity of Sales and Customers, and Video Forensics Technology in 2008
7. Olympus advances technology for laparo-endoscopic single-site surgery
8. New hope for advances in treating malaria
9. Using combinatorial libraries to engineer genetic circuits advances synthetic biology
10. Advances in lung cancer research announced at conference
11. JDRF-funded research advances potential for regeneration as a possible cure for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... KNOXVILLEToday,s students in college biology and other science ... in quantitative ways, and now they have a ... for the Life Sciences," published this month by ... National Institute for Mathematical and Biological Synthesis (NIMBioS), ... that can be used to explore and explain ...
(Date:8/19/2014)... A team of UTSA researchers has been awarded a ... Technology and Training (NCPTT), an office of the National ... The grant will fund a one-year study of the ... of historic homes in hot, humid climates. , Radiant ... or attics that reflect heat back, thereby reducing the ...
(Date:8/19/2014)... to humans and animals in a number of ways. ... them to regrow entire organs. After being struck by ... entire crown. But there is one major downside to ... to the habitats in which they live and therefore ... to this dilemma, plants have developed mechanisms that enable ...
Breaking Biology News(10 mins):New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3How steroid hormones enable plants to grow 2
... million people in 36 countries of sub-Saharan Africa are ... African sleeping sickness. The disease is caused by organisms ... African sleeping sickness affects approximately 500,000 people in sub-Saharan ... Because the trypanosome has an exceptional genetic strategy for ...
... headed by Professor Hans-Georg Kräusslich at Heidelberg University ... Applied Tumor Virology of the Deutsches Krebsforschungszentrum (German ... to label Human Immunodeficiency Viruses (HIV) for visual ... virus. , The labeling permits scientists to observe ...
... virologists headed by Professor Hans-Georg Kräusslich at Heidelberg ... of Applied Tumor Virology of the Deutsches Krebsforschungszentrum ... first to label Human Immunodeficiency Viruses (HIV) for ... the virus. , The labeling permits scientists to ...
Cached Biology News:Newly discovered protein an important tool for sleeping sickness research 2New Species of Coral Discovered Off Southern California 2Virologists make major step towards understanding the process of HIV infection 2
(Date:8/19/2014)... -- Research and Markets  has announced the addition of the ... report to their offering. This report analyzes ... Thousands by the following Product Segments: Media, Sera, and Reagents. ... Canada , Japan , ... Latin America . Annual estimates and forecasts are provided for ...
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
(Date:8/19/2014)... 19, 2014 Robin Williams’ passing is ... take on an individual. Symptoms range from slowness ... problems swallowing and severe depression. Parkinson’s disease progressively ... of dopamine producing neurons of the brain. As ... that slowly and progressively gets worse, they look for ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
Breaking Biology Technology:Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2
... worked for almost seven years in secret. , Most ... Goehner,s materials characterization department at Sandia National Laboratories was ... containing bacillus anthracis, the spores that cause the disease ... 2001 to several news media offices and to two ...
... in the nanocrystals of semiconductors to cool more slowly ... the potential to improve satellite communications and the generation ... these electronsin this case, by more than 30 timescould ... Guyot-Sionnest, Professor of Chemistry and Physics at the University ...
... Nov. 13 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) ... &,Company, LLC,s Focus on Infectious Disease Conference on Thursday, ... at the Needham and Company,LLC,s office in New York ... Officer of Anadys,will present an overview of Anadys and ...
Cached Biology Technology:FBI unveils science of anthrax investigation 2FBI unveils science of anthrax investigation 3New research expected to improve laser devices and make photovoltaics more efficient 2Anadys Pharmaceuticals to Present at the Needham Focus on Infectious Disease Conference 2
... TriEx Sf9 Cells and TriEx Insect Cell ... pTriEx baculovirus constructs. This cell/medium combination has ... growth and high protein expression levels observed ... vectors. Please note that our Ready-Plaque Sf9 ...
...
...
...
Biology Products: