"This is the first study that identifies RRM2 expression as a negative prognostic factor in resected stage I-III NSCLC," they report.
"RRM2 was identified as an unfavorable prognostic marker in our study population and this is in agreement with its crucial role in supplying deoxyribonucleotides for DNA synthesis and repair and with the finding that cells overexpressing RRM2 exhibit enhanced cellular invasiveness," Dr Dal Bello explained.
Because of the high and rapid recurrence rate of lung cancer, prognostic markers to identify patients with higher risk of relapse represent a high unmet medical need. "The prognostic role of RRM2 can help to identify patients at higher risk of relapse who may benefit from adjuvant chemotherapy," she noted.
Epigenetic clues distinguish tumor types
Dr David Shames from a San Francisco, Californiabased biotechnology company and colleagues report that epithelial-like lung tumors, which have a better prognosis and exhibit greater sensitivity to inhibitors of the EGFR pathway, can be distinguished from mesenchymal-like tumors on the basis of global DNA methylation patterns.
DNA methylation is an important form of 'epigenetic' modification, which affects the expression of genes within cells.
Using cancer cell lines and surgically resected non-small cell lung cancer tumors, the researchers showed that patterns of DNA methylation can divide non-small cell lung cancer into two phenotypically distinct subtypes.
Their work also provides proof of principle, they say, that "differences in DNA methylation can be used as a platform for predictive biomarker discovery and development."
A promising biomarker of response to radiotherapy
In a further report, Dr Ioannis Trigonis from the Wolfson Molecular Imaging Centre and The Christie Hospital in Manchester, UK,
|Contact: Vanessa Pavinato|
European Society for Medical Oncology