Dr Celine Mascaux from the University of Colorado and collaborators report that the micro RNA miR-34c is a potential biomarker for histological response in lung cancer chemoprevention studies.
Chemoprevention is a way of preventing the development of cancer using medicines or other agents, including the prevention of cancer in at-risk individuals such as smokers.
Currently, the best intermediate endpoint for studies of chemoprevention is a histological grading of cells in the airways of the lungs. However, as Dr Mascaux's group notes, "more quantitative biomarkers of response would be desirable."
Dr Mascaux and colleagues analyzed the expression of selected micro RNAs as potential surrogate biomarkers in a lung cancer chemoprevention trial that compared a drug called iloprost to placebo in 125 former or current smokers.
In a recent study, oral iloprost has shown promise to prevent the development of lung cancer in high-risk people.
After analyzing 14 different micro RNAs from 496 lung biopsies, they found that change in the expression of a particular micro RNA -- miR-34c -- in follow-up biopsies was inversely correlated with histological response.
Changes in the expression of this micro RNA may therefore be a quantitative biomarker of response in lung chemoprevention studies, they say.
RRM predicts shorter survival
Dr Giovanna Dal Bello and colleagues report that expression levels of ribonucleotide reductase subunit 2 (RRM2) predict shorter survival in patients whose non-small cell lung cancer had been surgically removed. In 82 patients, the Italian group found that RRM2 was an independent prognostic marker of shorter survival.
"The difference in overall survival between patients with high or low RRM2 levels was clinically relevant," said Dr Dal Bello from the National Institute for Cancer Research in Genoa, Italy. "In particular, mean survival time of patients with high
|Contact: Vanessa Pavinato|
European Society for Medical Oncology