Navigation Links
Advance in regenerative medicine could make reprogrammed cells safer while improving their function
Date:8/1/2013

NEW YORK (Aug. 1, 2013) -- The enormous promise of regenerative medicine is matched by equally enormous challenges. But a new finding by a team of researchers led by Weill Cornell Medical College has the potential to improve both the safety and performance of reprogrammed cells.

The researchers' study, published in today's issue of the journal Nature, found that an enzyme, activation-induced cytidine deaminase (AID), helps in the process that changes an adult human cell into an induced pluripotent stem cell (iPS cell). These iPS cells can then be developed into any kind of cell needed to therapeutically restore tissues and organs.

The finding settles an ongoing controversy regarding use of AID to reprogram cells, says the study's senior investigator, Dr. Todd Evans, vice chair for research and professor of cell and developmental biology in the Department of Surgery at Weill Cornell Medical College.

"The dispute was whether AID is required to make iPS cells, and we found that the enzyme does make reprogramming very efficient, although it is not absolutely necessary," says Dr. Evans, an internationally-recognized authority on regenerative medicine. "In fact, we plan to test if reprogramming iPS cells without AID may even be helpful."

One reason is that AID can cause genetic mutations that can lead to cancer. AID is best known as a master regulator of antibody diversity in B cells, and in order to create varied types of beneficial antibodies, it routinely mutates antibody genes. But sometimes the process goes awry, resulting in development of B cell lymphoma, Dr. Evans says. "That leads us to believe that if you can reprogram cells without AID, it could reduce risk of potential mutations, and thus be safer."

iPS Cells Without AID Remember What They Once Were

In order to push a cell, such as a fibroblast, to revert to an iPS cell, the epigenetic "markers" that define an adult cell must be removed.
'/>"/>

Contact: John Rodgers
jdr2001@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UCLA stem cell gene therapy for sickle cell disease advances toward clinical trials
2. MARC travel awards announced for the AAI 2013 Advanced Course in Immunology Meeting
3. Advance Research Associates Partners With MedNet Solutions
4. New sickle cell anemia therapy advances to Phase II clinical trials
5. OHSU scientists advance understanding of brain receptor; may help fight neurological disorders
6. Engineered stem cell advance points toward treatment for ALS
7. NSF approves planning grant for Center for Advanced Research in Drying
8. New advances in the management of patients with cirrhosis
9. Ludwig presents advancements in immunotherapy and epigenetics at the American Association for Cancer Research Annual Meeting
10. Ludwig advancements in immunotherapy and epigenetics top scientific program at AACR
11. Research advances therapy to protect against dengue virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... quality of the U.S. diet showed some modest improvement ... a reduction in the consumption of unhealthy trans fats, ... the rich and the poor. , , An unhealthy ... some cancers. Eating a healthy diet is an important ... Evaluating population trends in diet quality is important because ...
(Date:9/1/2014)... revealed the presence of tiny blob-like structures that form ... don,t know what they do even though these ... crucial to the life of a cell, and therefore ... the Journal of Cell Biology , two researchers ... from biophysics to cell biology, to focus their attention ...
(Date:8/31/2014)... A fast-sensitive "electronic-nose" for sniffing the highly infectious bacteria ... stomach cramps, has been developed by a team at ... the research team has demonstrated that it is possible ... which would lead to rapid diagnosis of the ... could be possible to identify different strains of the ...
Breaking Biology News(10 mins):Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3Scientists call for investigation of mysterious cloud-like collections in cells 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2
... of the peskiest household pests, while disastrous to homes, could ... Purdue University study. Mike Scharf, the O. Wayne Rollins/Orkin ... has discovered a cocktail of enzymes from the guts of ... that inhibit fuel production from woody biomass. The Scharf Laboratory ...
... A study from the microbiology lab at the Lifespan hospitals ... in identifying Clostridium difficile Toxin ( C. diff ... a molecular method detects up to 50 percent more cases ... technology is more expensive, it allows for more cases to ...
... Speculation that the welfare of a small, ... in part supported by new scientific research, according to a ... Ecosphere , a journal of the Ecological Society of America. ... whose population has plummeted over the last 15 years, has ...
Cached Biology News:Termites' digestive system could act as biofuel refinery 2Not all tests are created equal: Identifying C. diff in hospital labs 2Research bolsters importance of horseshoe crab spawning for migrating shorebirds 2
(Date:9/1/2014)... (PRWEB) September 01, 2014 The ... $1,712.1 million by 2019 from $1,070.7 million in ... 2014 to 2019. The global oligonucleotide synthesis market ... services, applications, end users, and geography. The synthesized ... growth rate in the oligonucleotide synthesis market during ...
(Date:8/31/2014)... , Aug. 31, 2014 Wockhardt Limited today ... program in Anti-Infective research when two of its drugs, ... Infectious Disease Product (QIDP) status from U.S. Food & ... which act against pathogens which have a high degree ... by Centre for Disease Control (a top U.S. government ...
(Date:8/31/2014)... 2014 2014 Market Research ... professional and in-depth research report on the ... information, including Polyacrylamide definition, classification, application, and ... overview. This research covers the international market ... global industry analysis covering macroeconomic environment & ...
(Date:8/30/2014)... TX (PRWEB) August 31, 2014 ... is a professional and in-depth study on the ... in Global and China. , The report provides ... applications and industry chain structure. Global market analysis ... a focus on history, developments, trends and competitive ...
Breaking Biology Technology:9.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 29.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 39.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 49.8% CAGR for Oligonucleotide Synthesis Market Globally to 2019 Says a New Research Report Available at RnRMarketResearch.com 5U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3
... Technologies,Inc. (OTC Bulletin Board: BNET) announced that notification was ... Waste,Bioconversion System" has been granted by the Commonwealth of ... 2002227224. The,official filing date is approved as November 8, ... expiration date of November 8, 2021., This patent ...
... ... FUNCTIONAL FOOD market-- LAVAL, QC, Sept. 25 /PRNewswire-FirstCall/ - ... it entered a worldwide alliance with Marine Life Sciences who ... distribution,of dietary supplements and functional food products in the global,nutraceutical ...
... 25 Osteotech, Inc.,(Nasdaq: OSTE ), a leader ... announced today the appointment of Cato T.,Laurencin, M.D., Ph.D. ... of Directors effective September 24, 2008 and will serve ... Board of Directors., Kenneth P. Fallon, III, Chairman ...
Cached Biology Technology:Bion Announces Approval of New Australian Patent for Low Oxygen Organic Waste Bioconversion for Livestock Waste Environmental Treatment 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 2Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 3Neptune Technologies and Marine Life Sciences enter worldwide distribution alliance with Weider Global Nutrition 4Cato T. Laurencin, M.D., Ph.D. to Join Osteotech Board of Directors 2
CQCS kit for first KR 4i , (first unit)....
... Wellpro 384, compatible ... automated liquid handling system ... quickly and accurately prepares ... dilutions. The Wellpro ...
...
...
Biology Products: