Navigation Links
Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
Date:6/30/2011

Bethesda, MDAdult stem cells and progenitor cells may not come with a clean genetic slate after all. That's because a new report in the FASEB Journal (http://www.fasebj.org) shows that adult stem or progenitor cells have their own unique "epigenetic signatures," which change once a cell differentiates. This is important because epigenetic changes do not affect the actual make up in a cell's DNA, but rather, how that DNA functions. Epigenetic changes have been shown to play a role in a wide range of diseases, including obesity, and have been shown to be heritable from mother to child.

"Ultimately, we hope to be able to decipher the mechanisms of how stem cells renew themselves as well as how they differentiate," said George L. Sen, Ph.D., a researcher involved in the work from the Division of Dermatology, Department of Medicine, Department of Cellular and Molecular Medicine, Program in Stem Cell Biology at the University of California, San Diego. "This will in turn allow us to coax these cells to behave in ways that we want to potentially aid in the treatment of tissue degenerative disorders."

Sen and colleagues drew their conclusions by mapping the DNA and histone methylation patterns in stem/progenitor cells and comparing them to differentiated cells. They found DNA and histone methylation "marks" on the promoter regions of differentiation genes in stem cells that prevented the expression of differentiation genes. They also showed that when the proteins used to mark the DNA were removed, stem cells would spontaneously differentiate. In regenerated human skin, the loss of these marks (epigenetic factors) resulted in loss of the stem/progenitor cells in the basal layer of the skin. Over time, the skin no longer regenerated and prematurely differentiated.

"Epigenetics has not replaced classical genetics. It has, however, provided the chemical and biological explanation for short-term, heritable changes that tell cells where their parents have been and where they themselves are going," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "This study shows that adult stem and progenitor cells, like many human adults, come with baggage from family history that affects how they behave."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Genetic conductor involved with new brain cell production in adults
2. UCI, French researchers find master switch for adult epilepsy
3. Adolescents dieting and disordered eating behaviors continue into young adulthood
4. Social scientists study impact of human adult stem cell research
5. Developmental disease is recreated in an adult model
6. Religious young adults become obese by middle age
7. Virtual conversation simulator found beneficial for adults with autism
8. Rensselaer professor utilizing New York state grant to study adult stem cells
9. Happy children make happy adults
10. Treating fractures: Children are not miniature adults
11. CHOP-led study detects dozens of genes for adult height
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... YORK , Dec. 16, 2016 The global wearable ... USD 12.14 billion by 2021 from USD 5.31 billion in 2016, ... ... is mainly driven by technological advancements in medical devices, launch of ... rising preference for wireless connectivity among healthcare providers, and increasing focus ...
(Date:12/15/2016)... 2016 ... Research and Markets has announced the addition of the ... The report forecasts the global military biometrics market to grow at ... report has been prepared based on an in-depth market analysis with inputs ... prospects over the coming years. The report also includes a discussion of ...
(Date:12/15/2016)... 14, 2016 "Increase in mobile transactions is ... mobile biometrics market is expected to grow from USD ... 2022, at a CAGR of 29.3% between 2016 and ... the growing demand for smart devices, government initiatives, and ... "Software component is expected to grow at a high ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017  Market Research Future has a ... Market for Liquid Biopsy is growing rapidly and expected to reach ... Market Highlights ... The Global Liquid Biopsy Market has been assessed as a swiftly ... figures and boom in the coming future. There has been a ...
(Date:1/19/2017)... /PRNewswire -- WuXi AppTec, a leading global pharmaceutical, ... platform, today announced that it has acquired HD ... discovery contract research organization (CRO). After completion of ... of WuXi, and will continue to focus on ... The acquisition will further strengthen WuXi,s R&D capability ...
(Date:1/19/2017)... ... January 19, 2017 , ... Genedata, ... (R&D), today announced the launch of Data Science Services , offering ... evolving field of precision medicine. , Data Science Services allows pharmaceutical ...
(Date:1/19/2017)... GAITHERSBURG, Md. , Jan. 19, 2017 ... Inc., a privately-held immunotherapeutics company targeting infectious diseases, ... for the merger of PharmAthene and Altimmune in ... Venture Fund, HealthCap, Truffle Capital and Redmont Capital. ... diversified immunotherapeutics company with four clinical stage and ...
Breaking Biology Technology: