Navigation Links
Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
Date:6/30/2011

Bethesda, MDAdult stem cells and progenitor cells may not come with a clean genetic slate after all. That's because a new report in the FASEB Journal (http://www.fasebj.org) shows that adult stem or progenitor cells have their own unique "epigenetic signatures," which change once a cell differentiates. This is important because epigenetic changes do not affect the actual make up in a cell's DNA, but rather, how that DNA functions. Epigenetic changes have been shown to play a role in a wide range of diseases, including obesity, and have been shown to be heritable from mother to child.

"Ultimately, we hope to be able to decipher the mechanisms of how stem cells renew themselves as well as how they differentiate," said George L. Sen, Ph.D., a researcher involved in the work from the Division of Dermatology, Department of Medicine, Department of Cellular and Molecular Medicine, Program in Stem Cell Biology at the University of California, San Diego. "This will in turn allow us to coax these cells to behave in ways that we want to potentially aid in the treatment of tissue degenerative disorders."

Sen and colleagues drew their conclusions by mapping the DNA and histone methylation patterns in stem/progenitor cells and comparing them to differentiated cells. They found DNA and histone methylation "marks" on the promoter regions of differentiation genes in stem cells that prevented the expression of differentiation genes. They also showed that when the proteins used to mark the DNA were removed, stem cells would spontaneously differentiate. In regenerated human skin, the loss of these marks (epigenetic factors) resulted in loss of the stem/progenitor cells in the basal layer of the skin. Over time, the skin no longer regenerated and prematurely differentiated.

"Epigenetics has not replaced classical genetics. It has, however, provided the chemical and biological explanation for short-term, heritab
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic conductor involved with new brain cell production in adults
2. UCI, French researchers find master switch for adult epilepsy
3. Adolescents dieting and disordered eating behaviors continue into young adulthood
4. Social scientists study impact of human adult stem cell research
5. Developmental disease is recreated in an adult model
6. Religious young adults become obese by middle age
7. Virtual conversation simulator found beneficial for adults with autism
8. Rensselaer professor utilizing New York state grant to study adult stem cells
9. Happy children make happy adults
10. Treating fractures: Children are not miniature adults
11. CHOP-led study detects dozens of genes for adult height
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... 2014  Tute Genomics, a leader in cloud-based solutions ... A1 funding led by UK-based Eurovestech. Peak Ventures and ... investment round. "We are at a pivotal ... sequencing and seeks new approaches for the diagnosis, treatment ... MD MBA, and CEO of Tute Genomics. "One of ...
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... of painstaking study, the cooperation of hundreds of researchers, ... John Alroy thinks he,s disproved much of the conventional wisdom ... Alroy, a researcher with the National Center for Ecological Analysis ... author of a report published in the July 3 edition ...
... NOAA coral bleaching prediction system indicates that there will ... but the event will probably not be severe. NOAA ... at the 11th International Coral Reef Symposium in Ft. ... is a risk of widespread bleaching in the Northwestern ...
... Wilkins Ice Shelf is experiencing further disintegration that is threatening ... Charcot Island. Since the connection to the island in the ... likely the break-up of the bridge will put the remainder ... of images acquired by Envisat,s Advanced Synthetic Aperture Radar (ASAR) ...
Cached Biology News:UCSB researcher leads worldwide study on marine fossil diversity 2New NOAA coral bleaching prediction system calls for low level of bleaching in Caribbean this year 2Wilkins Ice Shelf hanging by its last thread 2Wilkins Ice Shelf hanging by its last thread 3
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat Pharma, ... 2 study evaluating the investigational oral NK-1 receptor ... with severe, chronic itch who are unresponsive or ... including topical steroids and antihistamines. ... Visual Analog Scale (VAS) itch score from baseline, ...
(Date:12/15/2014)... , Dec. 15, 2014 Organovo Holdings, ... company focused on delivering breakthrough 3D bioprinting technology,  ... and collaborators of its exVive3D TM Human ... available in full commercial release on November 18, ... resulting in several awards for innovation. ...
(Date:12/13/2014)... N.C. (PRWEB) December 13, 2014 CanDiag, ... Charlotte) spin-out company has changed its name to OncoTab, ... accurate representation of where we are today,” said CEO ... extended our platform’s applications beyond breast cancer diagnostics to ... a reflection of that evolution.” , Founded in 2011 ...
(Date:12/13/2014)... USA, and TAICHUNG, Taiwan (PRWEB) December 12, 2014 ... despite less rosy indicators in overall global economic growth, ... for optics and photonics , said in a featured ... Conference) on 5 December at the National Chung Hsing ... energy, which is being integrated into future energy supplies ...
Breaking Biology Technology:Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5
Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
Phospho-TAK1 (Thr184/187) (90C7) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
... polyclonal to MSY2/YBOX2 ( Abpromise ... Antigen: Synthetic peptide derived ... C-terminus of Human MSY2/YBOX2. (Note: ... (Peptide available as ...
SAPK/JNK Antibody...
Biology Products: