Navigation Links
Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
Date:6/30/2011

Bethesda, MDAdult stem cells and progenitor cells may not come with a clean genetic slate after all. That's because a new report in the FASEB Journal (http://www.fasebj.org) shows that adult stem or progenitor cells have their own unique "epigenetic signatures," which change once a cell differentiates. This is important because epigenetic changes do not affect the actual make up in a cell's DNA, but rather, how that DNA functions. Epigenetic changes have been shown to play a role in a wide range of diseases, including obesity, and have been shown to be heritable from mother to child.

"Ultimately, we hope to be able to decipher the mechanisms of how stem cells renew themselves as well as how they differentiate," said George L. Sen, Ph.D., a researcher involved in the work from the Division of Dermatology, Department of Medicine, Department of Cellular and Molecular Medicine, Program in Stem Cell Biology at the University of California, San Diego. "This will in turn allow us to coax these cells to behave in ways that we want to potentially aid in the treatment of tissue degenerative disorders."

Sen and colleagues drew their conclusions by mapping the DNA and histone methylation patterns in stem/progenitor cells and comparing them to differentiated cells. They found DNA and histone methylation "marks" on the promoter regions of differentiation genes in stem cells that prevented the expression of differentiation genes. They also showed that when the proteins used to mark the DNA were removed, stem cells would spontaneously differentiate. In regenerated human skin, the loss of these marks (epigenetic factors) resulted in loss of the stem/progenitor cells in the basal layer of the skin. Over time, the skin no longer regenerated and prematurely differentiated.

"Epigenetics has not replaced classical genetics. It has, however, provided the chemical and biological explanation for short-term, heritable changes that tell cells where their parents have been and where they themselves are going," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "This study shows that adult stem and progenitor cells, like many human adults, come with baggage from family history that affects how they behave."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related biology news :

1. Genetic conductor involved with new brain cell production in adults
2. UCI, French researchers find master switch for adult epilepsy
3. Adolescents dieting and disordered eating behaviors continue into young adulthood
4. Social scientists study impact of human adult stem cell research
5. Developmental disease is recreated in an adult model
6. Religious young adults become obese by middle age
7. Virtual conversation simulator found beneficial for adults with autism
8. Rensselaer professor utilizing New York state grant to study adult stem cells
9. Happy children make happy adults
10. Treating fractures: Children are not miniature adults
11. CHOP-led study detects dozens of genes for adult height
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2017 Who risk to be deprived of ... full report: https://www.reportbuyer.com/product/4313699/ WILL APPLE AND ... Fingerprint sensors using capacitive technology represent a fast ... Idex forecasts an increase of 360% of the number ... the fingerprint sensor market between 2014 and 2017 (source ...
(Date:3/1/2017)... -- Aware, Inc. (NASDAQ: AWRE), a leading supplier of biometrics ... has resigned, effective March 3, 2017, as co-Chief ... Treasurer of Aware citing a desire to retire.  Mr. ... the Board of Directors of Aware. ... co-President, General Counsel has been named Chief Executive Officer, ...
(Date:2/28/2017)... DORTMUND, Germany , February 28, 2017 ... ... Amsterdam from 14 to 16 March, ... to destination, and show how seamless travel is a real benefit ... Materna has added biometrics to their passenger touch point solutions to ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... 30, 2017  Jazz Pharmaceuticals plc (Nasdaq: ... license agreements with Nippon Shinyaku, Co., Ltd. for Defitelio ... and daunorubicin liposome injection), or CPX-351, in ... the agreements, Nippon Shinyaku will receive exclusive rights to ... Japan in return for an upfront payment ...
(Date:3/29/2017)... Washington, PA (PRWEB) , ... March 29, 2017 ... ... largest non-profit, voluntary, health organization dedicated to finding cures for inflammatory bowel diseases ... healthcare professionals, have partnered to deliver exclusive content to ReachMD learners. , ...
(Date:3/29/2017)... March 29, 2017 "Surging application of gesture ... the government are expected to drive the growth of ... gesture recognition market is expected to be worth USD ... 29.63% between 2017 and 2022. The touchless sensing market ... 2022, growing at a CAGR of 17.44% between 2017 ...
(Date:3/29/2017)... Addison, Tx (PRWEB) , ... March 29, 2017 ... ... is honored to announce that Nerium International Mexico has been approved as an ... AMVD works to achieve satisfaction and protection among distributers and consumers in relationship ...
Breaking Biology Technology: