Navigation Links
Adult stem cell breakthrough
Date:11/19/2008

even-centimetre tracheal segment was donated by a 51-year-old transplant donor who had who had died of cerebral haemorrhage. Spain has a policy of assumed consent for organ donation. Using a new technique developed in Padua University, the trachea was decellularised over a six-week period so that no donor cells remained.

Stem cells were obtained from the recipient's own bone marrow, grown into a large population in Professor Martin Birchall's lab at the University of Bristol, and matured into cartilage cells (chondrocytes) using an adapted method originally devised for treating osteoarthritis by Professor Anthony Hollander at the University of Bristol.

The donor trachea was then seeded with chondrocytes on the outside, using a novel bioreactor which incubates cells, developed at the Politecnico di Milano, Italy, allowing them to migrate into the tissue under conditions ideal for each individual cell type. In order to replicate the lining of the trachea, epithelial cells were seeded onto the inside of the trachea using the same bioreactor.

Four days after seeding, the graft was used to replace the patient's left main bronchus. The operation was performed in June 2008 at the Hospital Clinic, Barcelona, by Professor Paolo Macchiarini of the University of Barcelona.

Professor Macchiarini, lead author on the paper, said: "We are terribly excited by these results. Just four days after transplantation the graft was almost indistinguishable from adjacent normal bronchi. After one month, a biopsy elicited local bleeding, indicating that the blood vessels had already grown back successfully".

Martin Birchall, Professor of Surgery at the University of Bristol, added: "Surgeons can now start to see and understand the very real potential for adult stem cells and tissue engineering to radically improve their ability to treat patients with serious diseases. We believe this success has proved that we are on the verge of a new age in su
'/>"/>

Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
44-077-294-21885
University of Bristol
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. SNPs affect folate metabolism in study of Puerto-Rican adults
2. Scripps research scientists identify compounds for stem-cell production from adult cells
3. Turtle doves commit adultery
4. Efavirenz-based initial therapies associated with better outcomes in HIV-infected adults
5. NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells
6. Researchers discover atomic bomb effect results in adult-onset thyroid cancer
7. Adults who eat eggs for breakfast lose 65 percent more weight
8. Adult stem cells activated in mammalian brain
9. Childrens Memorial Hospital of Chicago receives a grant from BioMarin to support adult PKU outreach
10. Salk researchers reprogram adult stem cells in their natural environment
11. U of M researchers discover gene linked to adult-onset obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... 4, 2014 Increased emphasis on product ... new testing and inspection technologies. The convergence of ... a range of innovative test solutions. This trend ... Y, which is generally more inclined towards communication, ... development strategies of test equipment vendors will cater ...
(Date:12/3/2014)... Dec. 2, 2014 As part of our ... Technologies is pleased to announce the release of a ... to collect the workforce data that they need. ... been left by existing readers. Many such devices have ... and modern technology. Older models force users to navigate ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... attaining a reliable water supply for California and ... realized until better planning can identify how trade-offs ... water is limited, says a new report from ... been ineffective in meeting these goals because management ...
... Research led by Lauren Cole, a public health graduate ... Health and Director of the Epidemiology Program at LSU ... of head and neck cancer has risen at sites ... greatest increase among middle-aged white men. At the same ...
... An international team of researchers led by the University ... discovery of a breast cancer risk gene and could assist ... Melissa Southey of the Genetic Epidemiology Laboratory, Department of Pathology ... it was a significant discovery and the first breast cancer ...
Cached Biology News:Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 2Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 3Increasing water scarcity in California's Bay-Delta will necessitate trade-offs; 'hard decisions' needed to balance various environmental risks 4LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men 2Breast cancer risk gene discovery fast tracked by new technology 2
(Date:12/17/2014)... USA (PRWEB) December 16, 2014 ... manager at Philipps- Universität Marburg’s Department of Physics, ... photonics, in the newly released SPIE Women ... never be too shy to ask questions.” , ... technology, engineering, and mathematics) occupations ranging from university ...
(Date:12/17/2014)... Ipsen Biopharmaceuticals, Inc., an affiliate ... IPSEY), today announced that Somatuline® Depot® (lanreotide) ... approved by the U.S. Food and Drug Administration ... (GEP-NETs) in adult patients with unresectable, well or ... improve progression-free survival (PFS). , “The approval of ...
(Date:12/17/2014)... This report is a professional and ... an overview analysis, the report introduces quartz tubing ... industry overview, policy analysis, and news analysis, etc. ... witnessed rapid development with key manufacturers increasing their ... mentions quartz tubing upstream raw materials and equipment, ...
(Date:12/17/2014)... Menlo Park, CA (PRWEB) December 17, 2014 ... Inc. announces today that it has entered into ... Daniels Midland Company (ADM) to apply DNA2.0’s proprietary ... industrial enzyme engineering process. , “We are extremely ... our ProteinGPS engineering platform. This proprietary bioengineering ...
Breaking Biology Technology:Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 82020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2
... P&G,s Commitment to Sustainable Innovation., Accelerates LS9,s Entry into ... ... South San Francisco, CA (PRWEB) -- LS9, Inc., the ... Procter and Gamble (NYSE: PG), one of world,s largest consumer ...
... goBalto.com , ... San Francisco, CA ... partnering site for the pharmaceutical development and drug manufacturing industry, ... of India-based Investigator Sites and hospitals available on goBalto.com. , ...
... Reprints NRx for the Force.com AppExchange saves time for ... process from within Salesforce CRMSANTA MONICA, Calif., May 19 ... announced the availability of Reprints NRx for ... the Force.com platform, Reprints NRx for the AppExchange is ...
Cached Biology Technology:LS9 and Procter & Gamble Launch Sustainable Chemicals Partnership 2goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 2goBalto Partners with Maya Clinicals to Expand Its List of Investigator Sites 3Reprints Desk Medical Reprint Service Now Available to Life Science Professionals on the Force.com AppExchange 2Reprints Desk Medical Reprint Service Now Available to Life Science Professionals on the Force.com AppExchange 3
Ms anti-Cyclophilin D...
... to qualitatively detect EGFR ... paraffin-embedded (FFPE) tissue sections, ... cell preparations, using Chromogenic ... Fluorescent In Situ Hybridization ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient...
Biology Products: