Navigation Links
Adolescent exposure to thc may cause immune systems to go up in smoke
Date:9/30/2014

When it comes to using marijuana, new research, involving mice and published in the October 2014 issue of the Journal of Leukocyte Biology, suggests that just because you can do it, doesn't mean that you should. That's because a team of Italian scientists have found that using marijuana in adolescence may do serious long-term damage to the immune system. This damage may result in autoimmune diseases and chronic inflammatory diseases, such as multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis in adulthood.

"I hope that the knowledge that early exposure to marijuana is associated with immediate and long-term deleterious effects on the immune system may reach adolescents and their families," said Paola Sacerdote, Ph.D., a researcher involved in the work from the Universit degli Studi di Milano in Milano, Italy. "The increased risk of getting sick in adulthood may hopefully be a deterrent for marijuana abuse among young individuals."

To make this discovery, scientists injected "adolescent" mice with THC, the main active component of marijuana, for 10 days. This period in the mouse lifecycle corresponded to the adolescence period in humans (approximately ages 12-18). A second group of adolescent mice received only a placebo. At the end of treatments, both groups of animals were left undisturbed for approximately two months, until they reached full adulthood. The activity of the immune system was then evaluated, taking into consideration several important measurements, such as the ability of leukocytes to produce cytokines to mount an antibody response to vaccination or the capacity of macrophage to phagocyte particles. The group of mice treated with THC in adolescence had severe alterations of immune responses in adulthood, characterized by a clear switch toward a pro-inflammatory and cytotoxic phenotype.

"The immune system is characterized by an impressive ability to 'remember' previous exposures and changes during the period of immune system development especially early in life can have important long-term consequences," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "These studies not only point to adolescence as a key phase of immune system sensitivity, but also highly the dramatic and long-lasting negative effects that a common recreational drug abused by teenagers may have on immune function."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
@fasebopa
Source:Eurekalert

Related biology news :

1. Size at birth affects risk of adolescent mental health disorders
2. Risk of diabetes in children and adolescents exposed to antipsychotics
3. New insights into why adolescents carry meningitis-causing bacteria
4. Adolescents from southern Europe are less fit and more obese than central-northern European peers
5. Bionic pancreas controls blood sugar levels in adults, adolescents with type 1 diabetes
6. Managing Type 1 diabetes as an adolescent
7. Different eggs in adolescent girls and adult women
8. Findings announced from landmark study on safety of adolescent bariatric surgery
9. NIH awards UCI $10 million to study early-life origins of adolescent mental disorders
10. Cushioned heel running shoes may alter adolescent biomechanics, performance
11. Iron, vitamins could affect physical fitness in adolescents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2019)... N.J. (PRWEB) , ... August 02, 2019 , ... ... to assist the life science industry in advancing the development of medical therapies, ... been recognized by PharmaVOICE magazine as one of the “100 Most Inspiring People ...
(Date:8/1/2019)... , ... July 31, 2019 , ... ... personalized treatment. Check your local listings for more information. , Factor Bioscience Inc. ... of cancer and genetic and age-related diseases. This segment of Advancements will explore ...
(Date:7/23/2019)... ... July 23, 2019 , ... ... web-based genetic counseling, today announced that the company has expanded its database of ... (MAP), familial hypercholesterolemia (FH), and Parkinson’s disease. , The expanded content comes following ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... ... Stem Cells Inc. (PSC) , has announced that their GMP facility for cell ... Drug Branch for manufacturing. This is an important milestone for VetStem as ...
(Date:6/6/2019)... ... ... WCCT Global, Inc ., a full-service early phase contract research organization (CRO) ... 3 awards at the 2019 CRO Leadership Awards, to be held on June 24, ... Quality and Compatibility (Access to desired markets, cultural fit, timely project communications etc.) and ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... the USPTO providing proprietary interest to our methodology, processes, and diagnostic techniques. ... AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep scoring methodology. ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
Breaking Biology Technology: