Navigation Links
Adjuvant combo shows potential for universal influenza vaccine
Date:6/8/2011

fter infection. Mice whose vaccines contained either alum or MPL adjuvants lost less weight but did not fully regain their original weight. Mice whose vaccines contained both adjuvants together lost about 5 percent of their original weight and regained it all back rapidly.

The researchers also found that mice receiving vaccines with both adjuvants had the fewest viral particles in their lungs four days after infection.

Further experiments revealed that alum promoted long-lived CD8 memory cells, but that MPL was required to produce activated cells, ready and able to kill. The findings were published in the May 10, 2011, issue of the Proceedings of The National Academy of Sciences.

Current influenza vaccines use antigens against two proteins on the viral surface, neuraminidase (N), and hemagglutinin (H), to which antibodies can bind. Because these cell-surface proteins mutate frequently, new vaccines must be formulated each year to recognize a viral strains.

Killer T cells instead recognize viral fragments displayed on the surface of infected cells. The researchers used as their vaccine a fragment from the viral nucleus, which rarely changes. This suggests the possible development of a universal flu vaccine that would not have to be reformulated and administered every year.


'/>"/>

Contact: William Allstetter
allstetterw@njhealth.org
303-398-1002
National Jewish Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Phase III study compared neoadjuvant therapy with lapatinib or trastuzumab for early breast cancer
2. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
3. Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
4. UT Southwestern researchers use drug-radiation combo to eradicate lung cancer
5. Graphene and spintronics combo looks promising
6. Long-term study shows effect of climate change on animal diversity
7. New approach to treating cystic fibrosis lung infection shows promise
8. Research shows Brazilian acai berry antioxidants absorbed by human body
9. Wildfires cause ozone pollution to violate health standards, new study shows
10. New CU-Boulder study shows diversity decreases chances of parasitic disease
11. U of MN study shows link between gene variations and cancer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
(Date:6/17/2015)... GERMANTOWN, Maryland , June 17, 2015 ... Produktlinie mit DNA-Tests verbessert den Analyseprozess und senkt Laborkosten ... Frankfurt Prime Standard: QIA) hat heute in den ... Investigator ® für die forensische ... Kits zur Erstellung genetischer Fingerabdrücke bieten eine integrierte Lösung ...
(Date:6/16/2015)... , June 16, 2015  With the increasing ... security remains a top concern. The recent compromise of ... the need for strong authentication within government agencies. ... a biometric one-time password (OTP) authenticator, has been submitted ... (FIPS) 140-2 Level 3 validation for tamper proofing. ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... recently sent to President Obama, more than 200 organizations, ... lauded the President for his outstanding leadership in advancing ... the letter below. Dear Mr. President: ... higher education communities, we wish to commend you and ...
... and limited water availability are major stresses for plants ... Ben-Gurion University of the Negev has announced the ... a subsidiary of Bayer CropScience based in Ghent, Belgium, ... builds upon the expertise and breakthrough results from Dr. ...
... is certainly not free of risk. Since 2005, the ... and Gttingen have registered a total of 17 patients ... pharmacologist Dieter Mller and his coauthors describe the documented ... Deutsches rzteblatt International (Dtsch Arztebl Int 2009; 106(13): ...
Cached Biology News:Business, scientific, higher education groups laud President Obama's commitment to science 2Ben-Gurion University of the Negev signs collaborative contract with Bayer CropScience 2
(Date:7/6/2015)... ... July 06, 2015 , ... Discovery of new ... are key drivers of the global molecular diagnostics market. BCC Research reveals in ... of new companion diagnostic tests will increase demand for inexpensive and accurate tests ...
(Date:7/5/2015)... (PRWEB) , ... July 06, 2015 , ... For many ... a user had a high-end machine such as a Varian Cary 4000-7000, a Perkin ... widespread was this design that even NIST used them for their SRM-2031 series going ...
(Date:7/3/2015)... , July 3, 2015 ... till 22 september 2015 på  http://www.openinnovationinscience.at ... Innovation in Science" som hålls i ... en färsk undersökning med internationella forskare och ... (LBG) är hälsovetenskapens två största utmaningar bristen ...
(Date:7/2/2015)... Ill. , July 2, 2015 College ... Colton Eakins are gaining invaluable real-world experiences while ... Technology this summer. The students will be ... Jeff Wereszczynski,s research group at IIT. The internship ... Tom Carter , Physics; Dr. Kathy Finan ...
Breaking Biology Technology:Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 2Demand for Personalized Medicine, Innovative Molecular Diagnostic Tests Spurring Big Growth, According to BCC Research 3FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 2FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 3Lansering av världens första program för öppen innovation för att utbilda forskare 2Lansering av världens första program för öppen innovation för att utbilda forskare 3COD Students Participate in Prestigious Summer Internships 2
... ORLANDO, Fla., Sept. 20 HelixLife™ recently launched ... DNA Products (Vitamins & Skin Serum), Anti-Acne Skin ... These product lines were developed in partnership with ... solutions to personal health and skin care using ...
... Amex: NBS ) ("NeoStem" or the "Company"), an ... announced today that its CEO, Dr. Robin Smith, is appearing ... FOX Business Network.   The show,s first segment ... air each upcoming Saturday at 1:30 p.m. Eastern Time through ...
... Agreement With L-1 Identity Solutions for the Purchase... -- PARIS, September 20, 2010 ... ... --> ... s = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
Cached Biology Technology:HelixLife Launches Custom Health Supplements, Anti-Aging and Acne Skin Serums 2FOX Business Network Airing In-Depth Look at NeoStem 2FOX Business Network Airing In-Depth Look at NeoStem 3Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 2Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 3Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 4Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 5Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 6Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 7Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 8Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 9Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 10Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 11Safran Enters Into a Definitive Agreement With L-1 Identity Solutions for the Purchase of L-1 Biometrics and ID Management Solutions Businesses 12
... Mouse P815 cells were cultured in DMEM ... In order to keep the antigens in ... The cells are arrayed on a 12-well ... surface specifically treated to enhance cellular attachment and ...
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
Biology Products: