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Adipose stem cell heart attack trial data published in JACC
Date:1/24/2012

San Diego Cytori Therapeutics (NASDAQ: CYTX) announced today the publication of previously reported six-month outcomes from APOLLO, the Company's European clinical trial evaluating adipose-derived stem and regenerative cells (ADRCs) in patients with acute myocardial infarction (heart attack or AMI), as Research Correspondence in the Journal of the American College of Cardiology. The APOLLO trial was a 14-patient, prospective, randomized, double-blind, placebo-controlled, feasibility trial (Phase I/IIA) evaluating autologous ADRCs extracted with the Company's proprietary Celution System for the treatment of patients suffering from acute myocardial infarction.

In the APOLLO trial all patients were treated with standard-of-care and subsequently underwent an abdominal liposuction. Each patient's adipose tissue was processed by the Celution System where ADRCs were extracted, washed and concentrated into a syringe of clinical grade cells. Within 36 hours of the myocardial infarction and no longer than 24 hours after undergoing percutaneous coronary intervention, patients received an injection of either 20 million ADRCs (n=10) or a placebo (n=4).

The publication reported:

  • Safety
    • The procedure could be safely performed in an acute setting
    • No side effects from ADRC delivery, processed using Celution
    • No increase in arrhythmias
  • Feasibility
    • Improvement in cardiac function by SPECT
    • Improvement in blood flow into the heart muscle (perfusion defect)
    • Reduction in scar formation (infarct size)

"Based on both the six and 18-month outcomes, which showed continued safety and sustained long-term benefits, we initiated ADVANCE, a pivotal, prospective, randomized, double-blind, European heart attack trial in up to 360 patients," said Christopher J. Calhoun, CEO for Cytori. "The goal of our ADRC therapy is to reduce scarring, preserve heart muscle beyond what can be
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Contact: Megan McCormick
mmccormick@cytori.com
858-875-5279
Cytori Therapeutics
Source:Eurekalert

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