Adiponectin is a metabolic link between obesity and bone miner...(inversely correlated with femur bone min...)

Date:11/25/2008

inversely correlated with femur bone mineral content, further emphasizing that a high level of adiponectin impedes bone development at not only the lumbar spine but also the hip. Whether or not the delay in bone development resolves in later life or is sustained and leads to an increased risk of fragility fracture, particularly during aging when bone loss rapidly occurs due to declining levels of sex steroids, requires further investigation.

In summary, elevated circulating adiponectin was associated with lower bone mass and weaker bones in growing mice compared to control animals. Furthermore, these effects of adiponectin were observed in the absence of differences in body weight between the two groups of mice. Dr. Archer commented, "A unique and important feature of the adiponectin transgenic mice is that they exhibit significantly elevated circulating adiponectin but have similar body weights as control animals, thus eliminating obesity from confounding the study findings mechanical load resulting from an obese state can modulate bone metabolism". Moreover, Dr. Archer said, "female mice exhibited a stronger response than males, and this is likely due to the sexual dimorphism in these mice whereby females have significantly higher circulating levels than males".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said " These intriguing results form the University of Toronto team supplies significant insight into adiponectin secretion, from adipocytes, and loss of bone mineral density and resulting increased fractures. I consider this a major advance for this field of research.

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Contact: Dr. Wendy Ward wendy.ward@utoronto.ca 416-946-7366 Society for Experimental Biology and Medicine Source:Eurekalert

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