Navigation Links
Adiponectin is a metabolic link between obesity and bone mineral density
Date:11/25/2008

Researchers at the University of Toronto, Faculty of Medicine, Toronto, Canada, have discovered that adiponectin, a protein secreted from adipocytes, is a metabolic link that can explain, in part, the known positive relationship between obesity and both bone mineral density and reduced susceptibility to fractures. This study appears in the December issue of Experimental Biology and Medicine. Circulating adiponectin levels are significantly lower in obese humans and rodent models than in lean controls. It is known that excess body weight and elevated body mass index are strongly correlated with high bone mineral density, and that weight loss is associated with loss of bone mineral density and increased risk of fractures. However, the mechanism for this relationship is unclear.

The research team, Dr. Michael C. Archer, Earle W. McHenry Professor and Chair, Dr. Wendy E. Ward, Associate Professor, Dr. Kafi Ealey, Postdoctoral Fellow and predoctoral student Jovana Kaludjerovic, in the Department of Nutritional Sciences, investigated whether adiponectin modulates bone development using transgenic mice that overexpress this protein. These mice were initially developed by Dr. P. Scherer's research group at Albert Einstein College of Medicine, N.Y. Bone mineral density and biomechanical strength properties, surrogate measures of fracture risk at multiple skeletal sites, were the outcomes used to assess bone development. Female mice overexpressing adiponectin had weaker vertebra at 8 weeks of age than control mice and this delay in bone development persisted through to the end of the study period, representing early adulthood. The weaker vertebra model compression fractures of the lumbar spine in humans, among the most common type of fragility fracture associated with low bone mass and osteoporosis. The strength of the femur neck, representing the hip, was also weaker in both females and males overexpressing adiponectin. Serum adiponectin levels were
'/>"/>

Contact: Dr. Wendy Ward
wendy.ward@utoronto.ca
416-946-7366
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. For insulin sensitive overweight patients, 1 session of exercise improves metabolic health
2. Cortisol and fatty liver: Researchers find cause of severe metabolic disorders
3. New evidence on the robustness of metabolic networks
4. Bisphenol A linked to metabolic syndrome in human tissue
5. NYU dental professor discovers biological clock linking tooth growth to other metabolic processes
6. Metabolic Engineering VII
7. Powerful integration of lipid metabolic profiling with gene expression analysis
8. Tiny protein provokes healthy bonding between cells
9. Escherichia coli bacteria transferring between humans and mountain gorillas
10. Researchers find link between nicotine addiction and autism
11. Balance between traditional activities, tourism key to sustaining coastal Alaska communities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... 2015 Research and ... the "Huawei Ascend Mate 7 Fingerprint Sensor ... offering. Huawei,s technological choice for the ... than Apple,s and Samsung,s one. The Ascend Mate ... Fingerprint Cards, a main actor in capacitive sensing ...
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/17/2015)... , Deutschland und GERMANTOWN, Maryland , ... ®   Produktlinie mit DNA-Tests verbessert ... N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) ... neue STR-Testkits der Produktlinie Investigator ® ... den Markt eingeführt. Die neuen Kits zur Erstellung genetischer ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6
... fruits for snacks and serving vegetables at dinner can ... lifetime. To combat the increasing problem of childhood ... eat more fruits and vegetables. According to researchers at ... home interventions teaching parents how to create an ...
... researchers has uncovered the role of a family of ... tumours into more aggressive, potentially fatal, cancers in the ... the international journal Cancer Cell, provides valuable ... could ultimately change treatment options for sufferers around the ...
... German Research Vessel Polarstern had to prove its ice ... two series of long-term research measurements. After working in ... Alfred Wegener Institute for Polar and Marine Research in ... on August 10th. "This year, we had to ...
Cached Biology News:Parents shape whether their children learn to eat fruits and vegetables 2Parents shape whether their children learn to eat fruits and vegetables 3Monash researchers uncover cancer survival secrets 2Successful series of measurements in Arctic sea ice 2Successful series of measurements in Arctic sea ice 3Successful series of measurements in Arctic sea ice 4
(Date:7/2/2015)... ... July 02, 2015 , ... Sleepless nights will become obsolete as Luzi ... its Indiegogo campaign on June 23. Sound sleepers and the sleep deprived both will ... to use, while the integration of the Bluetooth speaker, alarm clock and ability to ...
(Date:7/1/2015)... and PARIS , ... AgBiome, and Genective, key developer of biotech crops, ... discovery of new generations of insect control traits. ... control to counter the realities of advancing insect ... aligning AgBiome,s unique insect control technology with Genective,s ...
(Date:7/1/2015)... AURORA, Colo. and BANGALORE, India ... a global genomic profiling company that uses next generation ... appointment of Scott A. Storrer as chief ... and CEO, he will be responsible for all strategy, ... Vijay Chandru , who has served as Strand,s chairman ...
(Date:7/1/2015)... Isagenix International, a leading global health and ... Silver, and three Bronze Stevie® Awards at the 2015 ... Chicago this month.The American Business Awards ... in the U.S. "Winning is a ... leaders, cultivating talent, creating a unified team, and crafting ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3AgBiome and Genective collaborate to create novel insect-resistant crops 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3
... of Wisconsin Medical Foundation is initiating a program ... data and to improve the reliability of the organization's ... Platform V Integration Services from Quovadx, Inc., ... Colorado. , ,The Medical Foundations growth has created ...
... Madison, Wis. -- Paul Voss looks at the future ... demographic predictions could reveal upcoming trends in the technology ... professor of rural sociology from the University of Wisconsin-Madison ... Thursday in a presentation titled Americas Changing Demographic Portrait. ...
... If the mood of 600+ technology executives, investors, and media is ... Homestead CEO Justin Kitch captured it best when he said DEMO ... the good ol' Internet." , ,Kitch's sentiments were repeated by dozens ... the event. There is a feeling in this industry unlike any ...
Cached Biology Technology:UW Medical Foundation Integrates Medical Records 2Using Demographic Predictions, UW Prof Expounds Upon Trends in Tech 2The Tech Market is Looking Up 2The Tech Market is Looking Up 3The Tech Market is Looking Up 4