Navigation Links
Addictive properties of drug abuse may hold key to an HIV cure
Date:9/21/2012

TALLAHASSEE, Fla. A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments.

Working under the support of a $1.8 million grant from the National Institutes of Health (NIH), Florida State biologist Jonathan Dennis is studying a unique ability shared between a promising class of HIV treatments known as histone deacetylase inhibitors (HDIs) and psychostimulant drugs such as cocaine.

"Current HIV treatments do just that they treat the disease by preventing the spread of HIV in the body, rather than eliminating the disease entirely," Dennis said. "I want to find out how to root out those dormant HIV cells that are evading the treatment, and I believe the gene-controlling functions shared by HDIs and psychostimulant drugs hold the key to helping us do that."

HDI and addictive drugs such as cocaine share the ability to control gene expression through changes in the chromatin structure within DNA. In the case of HDI treatment, the chromatin changes are used to wake up dormant HIV virus cells that are hiding in the body.

Dennis believes that addictive drugs do the same thing. Dennis' work will focus on identifying and understanding the overlapping gene changes that occur between these two types of substances, ultimately providing other researchers with the foundational information they need to turn HDI treatments into HIV cures.

To learn more about the scope and purpose of Dennis' NIH grant, visit the grant website. To learn more about Dennis, visit his Department of Biological Science website.


'/>"/>

Contact: Tom Butler
tbutler@admin.fsu.edu
850-644-8634
Florida State University
Source:Eurekalert

Page: 1

Related biology news :

1. Physicists explore properties of electrons in revolutionary material
2. Trial launched into curry chemicals cancer-fighting properties
3. Mechanical properties and microstructure of cranial and beak bones of the woodpecker and the lark
4. RI Hospital: Use of PMP may increase demand for drug treatment, reduce painkiller abuse
5. BUSM researchers find link between childhood abuse and age at menarche
6. Increasing clarity for medics in suspected physical abuse cases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... today announced the launch of the Supplyframe Design Lab . Located in ... to explore the future of how hardware projects are designed, built and brought ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a ... designed, tuned and optimized exclusively for Okuma CNC machining centers at The International ... a collaboration among several companies with expertise in toolholding, cutting tools, machining dynamics ...
Breaking Biology Technology: