Navigation Links
Addex scientists discover GLP-1 induced interaction between GLP-1 and GIP receptors
Date:11/28/2011

ubtypes. Furthermore, the pharmacology of this GLP-1-induced heteromeric receptor complex was found to be affected in presence of GIP. In addition, the heteromer's intracellular signaling through beta-arrestin or calcium second messenger was shown to be modified when compared to receptor homodimers, suggesting a form of allosteric regulation between the receptors.

"This research demonstrates how our pioneering allostery platform technology is able to observe specific interactions at the receptor level that have not been seen with conventional state-of-the-art techniques," noted Laurent Galibert, head of metabolic disease programs at Addex Pharmaceuticals. "An orally available small molecule targeting GLP1R would have a significant impact on the treatment of Type 2 diabetes. We now have the opportunity to explore and characterize this receptor further, paving the way for a better understanding of the signaling pathways implicated in diabetes and metabolism, which may offer novel therapeutic targets for allosteric modulation."

GLP-1 is an important metabolic hormone and a proven therapeutic ligand for treatment of diseases, such as Type II diabetes and obesity. Addex is leading the effort towards the development of orally available small molecule GLP1R activators, called positive allosteric modulators or PAM, which have potential to offer multiple advantages over marketed injectable peptide therapeutics targeting GLP1R.

Addex has previously disclosed that it achieved the first in vivo preclinical proof of concept demonstrating that an oral small molecule GLP1R PAM could increase the release of insulin and improve glucose control in preclinical diabetes models. Addex GLP1R PAMs are in lead generation phase for Type 2 diabetes and could become the first-in-class orally available small molecule therapeutic agents against this target.


'/>"/>

Contact: Mike Sinclair
msinclair@halsin.com
44-207-318-2955
Halsin Partners
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hopkins scientists turn on fountain of youth in yeast
2. Scripps Research scientists uncover new role for gene in maintaining steady weight
3. Caltech scientists point to link between missing synapse protein and abnormal behaviors
4. Smithsonian scientists use fossil feathers reveal lineage of extinct, flightless ibis
5. UGA discovery changes how scientists think about plant cell wall formation
6. Iowa State University scientists genetically increase algae biomass by more than 50 percent
7. UGA scientists invent long-lasting, near infrared-emitting material
8. Scripps research scientists develop brand new class of small molecules through innovative chemistry
9. Scientists identify treatable weakness in lethal form of prostate cancer
10. Scientists tackle the carbon conundrum
11. GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... a ceremony held in New York City on September ... the American Cancer Society Professor of Genome Sciences and ... 2008 Honorary Doctor of Philosophy of Tel Aviv University, ... Medical Science. , In addition to her honorary degree ... at the TAU School of Medicine, and for the ...
(Date:10/29/2014)... those referred to as ,facultative, form part—together with other ... differentiates these cells from the others. However, they have ... to become stem cells again. This phenomenon is something ... cells that stimulate tissue growth, thus allowing the regeneration ... Knowledge of the underlying mechanism that allows these ...
(Date:10/29/2014)... in the living world compete with members of ... how much they invest into their competitive ability. ... get access to high-quality resources, while others seem ... the lower-quality resources that are left over for ... and human societies seems to fluctuate considerably over ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Evolution of competitiveness 2Evolution of competitiveness 3
... other groups have created a map of the world,s ... temperatures, ultra-violet radiation, weather systems, sedimentation, as well as ... The study, say the authors, will help to ... by identifying reef systems where biodiversity is high and ...
... Viruses fill the ocean and have a significant effect ... professor of biology at UC Santa Barbara and his ... of Ecology, Evolution, and Marine Biology, is the senior ... week by the International Society for Microbial Ecology ...
... published online this week in Nature Genetics , ... with universities in China and Denmark reports the first ... type of bladder cancer. Recognizing the genetic ... healthy neighbors may allow early genetic screenings for cancer ...
Cached Biology News:Worldwide map identifies important coral reefs exposed to stress 2Worldwide map identifies important coral reefs exposed to stress 3Decade-long study reveals recurring patterns of viruses in the open ocean 2Decade-long study reveals recurring patterns of viruses in the open ocean 3University of Colorado Cancer Center genetically sequences most common bladder cancer 2
(Date:10/30/2014)... NY (PRWEB) October 30, 2014 Whitehouse ... for its ICH Stability Testing and Package Test Capacity. ... investment centers on a dramatic increase in environmental chamber ... of stability, storage and aging samples to be securely ... of this major capital expenditure has already taken place ...
(Date:10/30/2014)... N.J. , Oct. 30, 2014  Regado Biosciences, ... it will hold a conference call and live audio ... EST to discuss its third quarter 2014 financial results. ... conference call by dialing (888) 347-1165 for domestic callers ... will be webcast live under the investor relations section ...
(Date:10/27/2014)... MILAN , October 27, 2014 ... the right to produce, exhibit and sell its ... sought to impeach their patent.      ... After four years of fighting, the definitive judgement ... designs and produces innovative and accessible hi-tech prostheses ...
(Date:10/27/2014)... Called the NOAH Protocol, this ... types of pediatric brain cancer. The implications for ... 30 years of research and development. Amber Larkin, ... one mom's determination can make a difference. ... and it’s only fitting that we’ve received FDA ...
Breaking Biology Technology:Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 3
... Tengion, Inc. (Nasdaq: TNGN ), a leader in ... and live audio webcast on Friday, March 25, 2011 at ... its fourth quarter 2010 financial results.   To ... (international) and reference access code 55045101. This ...
... N.J., March 18, 2011 Today, the Access Group--a ... structure; the formation of 2 business entities, Promidian and ... senior executive team leaders. The Access ... health care and life sciences industries to provide full-service ...
... 17, 2011 Quest Diagnostics Incorporated (NYSE: ... announced that its ColoVantage test has been approved by ... of patients in the state. It is believed to ... a venal blood specimen to be approved by the ...
Cached Biology Technology:Tengion To Host Conference Call To Provide a Business Update and Report Fourth Quarter 2010 Financial Results on March 25, 2011 2Introducing the Access Group and Its New Business Entities 2Introducing the Access Group and Its New Business Entities 3Introducing the Access Group and Its New Business Entities 4Introducing the Access Group and Its New Business Entities 5Introducing the Access Group and Its New Business Entities 6New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 2New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 3
... The DNA Engine Dyad instrument is the ... Featuring MJ's world-class thermal performance, the ... display, as well as point-and-click navigation via ... Dyad can be easily and economically expanded ...
... Tetrad 2 thermal cycler is a completely ... Tetrad chassis, and it accepts the full ... delivers the same precision in thermal performance ... Tetrad thermal cyclers, allowing easy transport of ...
ID clarifier: platform...
... Tetrad 2 thermal cycler accommodates a ... heat-pump assemblies), which hold different types ... computer drives an advanced graphical interface ... lid temperatures. Peltier heat pumps, built ...
Biology Products: