Navigation Links
Addex scientists discover GLP-1 induced interaction between GLP-1 and GIP receptors
Date:11/28/2011

Geneva, Switzerland, 28 November 2011 Addex Pharmaceuticals (SIX:ADXN), a leading biopharmaceutical company pioneering allosteric modulation-based drug discovery and development, announced today that its scientists have demonstrated that, in the presence of GLP-1, glucagon-like-peptide-1 receptor (GLP1R) can form a heterodimer receptor complex with gastric-inhibitory-peptide-receptor (GIPR). The discovery of this novel interaction between the two G-protein-coupled receptors (GPCR) has the potential to trigger the discovery of novel therapies for the treatment of diabetes. The findings were published online in the peer-reviewed journal Molecular Pharmacology (Lateral Allosterism in the Glucagon Receptor Family: GLP-1 Induces GPCR Heteromer Formation [Schelshorn et al., Molecular Pharmacology, Published online, doi: 10.1124/mol.111.074757]).

"GIPR and GLP1R are found together in pancreatic and nerve cells, and their roles in Type 2 diabetes make them important targets for drug development. Further research is needed to determine the pharmacological relevance of such heteromers but understanding their role may open the door to more refined therapies, particularly in metabolic disorders," explained Robert Lutjens, head of biology at Addex Pharmaceuticals and co-author of the publication. "This study demonstrates that Addex' allosteric modulation platform is a powerful tool for elucidating fundamental biological processes in addition to being the most sensitive method available for identifying allosteric modulators."

In the present study, the researchers at Addex used Bioluminescence Resonance Energy Transfer (BRET) techniques, calcium flux measurements, and microscopy to study receptor interactions within the glucagon receptor family of GPCRs. Through these techniques, a GLP-1-induced heteromer formation was exclusively observed in cells co-expressing GLP-1 with GIP receptors, but not with other receptors of the glucagon receptor s
'/>"/>

Contact: Mike Sinclair
msinclair@halsin.com
44-207-318-2955
Halsin Partners
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hopkins scientists turn on fountain of youth in yeast
2. Scripps Research scientists uncover new role for gene in maintaining steady weight
3. Caltech scientists point to link between missing synapse protein and abnormal behaviors
4. Smithsonian scientists use fossil feathers reveal lineage of extinct, flightless ibis
5. UGA discovery changes how scientists think about plant cell wall formation
6. Iowa State University scientists genetically increase algae biomass by more than 50 percent
7. UGA scientists invent long-lasting, near infrared-emitting material
8. Scripps research scientists develop brand new class of small molecules through innovative chemistry
9. Scientists identify treatable weakness in lethal form of prostate cancer
10. Scientists tackle the carbon conundrum
11. GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... -- This report analyzes the worldwide markets for Iris Biometrics ... the US, Canada , Japan ... , Middle East , and ... provided for the period 2013 through 2020. Also, a seven-year ... analytics are derived from primary and secondary research. Company profiles ...
(Date:2/24/2015)... 2015 Research and Markets ( ... "Global 2D Gesture Recognition Market 2015-2019" ... analysts forecast the Global 2D Gesture Recognition market ... the period 2014-2019 The increased demand ... one of the major trends in the market. ...
(Date:2/19/2015)... .19, 2015 Research and Markets ... the "Military Electro-Optical / Infrared Systems Market ... Platform - Forecast to 2020" report to ... systems market is expected to reach $16.35 billion ... This report segments the military electro-optical/infrared ...
Breaking Biology News(10 mins):World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3
... Research led by Liwei Chen, MD, PhD, Assistant Professor ... has found that there is an association between sugary drinks ... sugary drinks by just one serving a day, people can ... Circulation: Journal of the American Heart Association ., "We ...
... Durham, N.C. A research team led by scientists ... to simultaneously look at the effects of 125 mutations ... model to analyze the function of every known mutation in ... able to analyze the functions and interactions of all mutations ...
... is available in Spanish . , The working ... Sea) met in Bilbao from 5 to 11 May, 2010 to ... south platform. The meeting was coordinated by AZTI-Tecnalia Marine and Food ... in Bilbao (previously it was held there in May 2006). This ...
Cached Biology News:LSUHSC researcher finds surprising link between sugar in drinks and blood pressure 2Using fish to illuminate the architecture of inherited disease 2Using fish to illuminate the architecture of inherited disease 3Meeting of ICES/CIEM experts in Bilbao on state of demersal fish populations 2
(Date:2/26/2015)... MENLO PARK, Calif. , Feb. 26, 2015 /PRNewswire/ ... has released the latest version of the Governance ... organizations accomplish governance, risk and compliance (GRC) tasks across ... has also been updated to help customers better align ... Organizations of the Treadway Commission ) requirements. In response ...
(Date:2/26/2015)... Angeles, CA (PRWEB) February 26, 2015 ... an online demonstration to support life extension technologies and ... 8pm UTC, Universal Coordinated Time, on March 21st 2015, ... the world. , Eric Schulke, Founder of MILE, ... must act with urgency. The Movement for Indefinite Life ...
(Date:2/26/2015)...  NuGene International, Inc. ("NuGene") (OTCQB: NUGN), the ... hair rejuvenation, has announced that it has selected ... investor relations and strategic communications. ... diversification strategies – and we need to communicate ... Ali Kharazmi CEO of NuGene when announcing this ...
(Date:2/26/2015)... , Feb. 26, 2015 BioEnterprise today ... companies have attracted more than $2 billion in growth ... local and national investors, strategic sources, state – including ... half of the $2 billion has been raised in ... comes on the heels of the BioEnterprise Midwest ...
Breaking Biology Technology:Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 2Protiviti Governance Portal Helps Companies Drive Governance, Risk and Compliance Productivity Across Multiple Business Units 3Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4
... ANGELES, Oct. 30 Elekta, a pioneer in ... broadest portfolio,of stereotactic technology in the industry at ... Therapeutic Radiology and Oncology (ASTRO). Held,October 28-November 1 ... the,perfect forum for Elekta to showcase its latest ...
... CryoCor, Inc. (Nasdaq:,CRYO), a medical device company focused ... Edward F. Brennan, President and Chief,Executive Officer, and ... present at the CIBC World Markets 18th Annual ... 6, 2007 at 3:40 p.m. ET at,the Waldorf-Astoria ...
... (Nasdaq: DCGN ) today announced that it will report ... be issued on Monday, November,5, after the close of the ... of its conference call to discuss these results and recent,operating ... GMT. The webcast can be accessed through the Investors ...
Cached Biology Technology:Elekta Showcases Stereotactic Systems for Cancer Care at Astro 2007 2Elekta Showcases Stereotactic Systems for Cancer Care at Astro 2007 3Elekta Showcases Stereotactic Systems for Cancer Care at Astro 2007 4CryoCor to Present at CIBC World Markets 18th Annual Healthcare Conference 2deCODE genetics Announces Webcast of Conference Call to Discuss Third Quarter 2007 Financial Results 2
Smac/DIABLO (mouse) (CT) rabbit polyclonal antibody...
... Rabbit polyclonal to Taura Syndrome ... for all tested applications). ... Synthetic peptide: VTNSEGSTIL MNDIPITNQN VVLSKNVTDN ... corresponding to N terminal amino ...
Purified Mouse anti-Hu Actopaxin (pS8) Storage Temperature: Refrigerate(2 to 8C)...
... FastPlax Antibody is used to detect the ... surface of infected cells as early as ... of the FastPlax Titer Kit, which allows ... hours. The FastPlax Antibody can ...
Biology Products: