Navigation Links
Adaptation in mole blood aids tunnelling
Date:7/19/2010

'Super hemoglobin' allows moles to thrive underground. Researchers writing in the open access journal BMC Evolutionary Biology have made the first identification of an adaptation in the blood of Eastern moles which allows more efficient transport of carbon dioxide, facilitating the moles' burrowing behavior.

Kevin Campbell from the University of Manitoba, Canada, worked with a team of researchers to study the blood of three underground species of North American moles. He said, "Unlike terrestrial animals, moles are routinely exposed to conditions of low oxygen and high carbon dioxide. Burrowing is difficult in itself, but is made even more challenging by the requirement to re-breathe their own expired air. We've found that one species, the Eastern mole, appears to be uniquely adapted to underground life through the evolution of a special kind of hemoglobin in their blood that greatly enhances its carbon dioxide carrying capacity".

The researchers determined the genetic code for different hemoglobin components in the three mole species and measured how well these components bind to their usual target molecules. They also tested the oxygen binding properties of whole blood samples. Speaking about the results, Campbell said, "It has been speculated that the main mechanism for the moles adaptation to subterranean life revolves around the molecule 2,3-diphosphoglycerate, or DPG, that modulates hemoglobin's oxygen binding inside the blood cells. However, in the hemoglobin of the eastern mole, the key sites which would normally bind DPG are deleted, thereby allowing for the binding of additional carbon dioxide molecules".

Adds co-author Roy Weber, University of Aarhus, Denmark, "It would be interesting to see if the hemoglobins of other burrowing species exhibit comparable specializations". The team envisions that this line of research could lead to the development of improved artificial human blood substitutes with specially engineered properties.


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Source:Eurekalert

Related biology news :

1. Genetic adaptations key to microbes survival in challenging environment
2. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
3. Experiential learning teaches change and adaptation
4. Phylogenetic analysis of Mexican cave scorpions suggests adaptation to caves is reversable
5. Adaptation is (not) in the eye of the beholder
6. Scientist plans to test for blood pressure genes affected by age
7. Discovery of natural compounds that could slow blood vessel growth
8. New blood test for Down syndrome
9. On the trail of a targeted therapy for blood cancers
10. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
11. Building the blood-brain barrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2016 Checkpoint Inhibitors for Cancer – ... Are you interested in the future of cancer ... inhibitors. Visiongain,s report gives those predictions to 2026 ... level. Avoid falling behind in data or ... revenues those emerging cancer therapies can achieve. There ...
(Date:2/2/2016)... Va. , Feb. 2, 2016   ... award from the U.S. Army Research Office and ... the range and sensitivity of the company,s ... Past Accounting Mission and, more generally, defense-related DNA ... DNA phenotyping capabilities (predicting appearance and ancestry from ...
(Date:2/1/2016)... 2016 Rising sales of consumer ... touchfree intuitive gesture control market size ... of consumer electronics coupled with new technological advancements to ... size through 2020   --> ... technological advancements to drive global touchfree intuitive gesture control ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... Feb. 3, 2016  With the growing need ... that is underway, therapies such as monoclonal antibodies, ... whole host of indications are in high demand. ... the development and production of these therapeutics. However, ... and high costs, novel approaches and novel expression ...
(Date:2/3/2016)... 2016 New Jersey Health Foundation (NJHF) has ... for researchers in New Jersey ... demonstrates exciting potential.   James M. ... New Jersey Health Foundation Research Grant Program ... institutions— Princeton University, Rutgers University, Rowan University and ...
(Date:2/3/2016)... , ... February 03, 2016 , ... ... Linux and Unix visualization solutions today announced the addition of a powerful “Session ... users to see the current state of the remote Linux desktop or other ...
(Date:2/3/2016)... 2016  Today, Symphony Technology Group (STG) announced the ... leading provider of primary research and analytics-based insight for ... , a global information and technology services company serving ... will be integrated into IMS Health to form a ... capabilities. ...
Breaking Biology Technology: