Navigation Links
Adaptation in mole blood aids tunnelling
Date:7/19/2010

'Super hemoglobin' allows moles to thrive underground. Researchers writing in the open access journal BMC Evolutionary Biology have made the first identification of an adaptation in the blood of Eastern moles which allows more efficient transport of carbon dioxide, facilitating the moles' burrowing behavior.

Kevin Campbell from the University of Manitoba, Canada, worked with a team of researchers to study the blood of three underground species of North American moles. He said, "Unlike terrestrial animals, moles are routinely exposed to conditions of low oxygen and high carbon dioxide. Burrowing is difficult in itself, but is made even more challenging by the requirement to re-breathe their own expired air. We've found that one species, the Eastern mole, appears to be uniquely adapted to underground life through the evolution of a special kind of hemoglobin in their blood that greatly enhances its carbon dioxide carrying capacity".

The researchers determined the genetic code for different hemoglobin components in the three mole species and measured how well these components bind to their usual target molecules. They also tested the oxygen binding properties of whole blood samples. Speaking about the results, Campbell said, "It has been speculated that the main mechanism for the moles adaptation to subterranean life revolves around the molecule 2,3-diphosphoglycerate, or DPG, that modulates hemoglobin's oxygen binding inside the blood cells. However, in the hemoglobin of the eastern mole, the key sites which would normally bind DPG are deleted, thereby allowing for the binding of additional carbon dioxide molecules".

Adds co-author Roy Weber, University of Aarhus, Denmark, "It would be interesting to see if the hemoglobins of other burrowing species exhibit comparable specializations". The team envisions that this line of research could lead to the development of improved artificial human blood substitutes with specially engi
'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic adaptations key to microbes survival in challenging environment
2. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
3. Experiential learning teaches change and adaptation
4. Phylogenetic analysis of Mexican cave scorpions suggests adaptation to caves is reversable
5. Adaptation is (not) in the eye of the beholder
6. Scientist plans to test for blood pressure genes affected by age
7. Discovery of natural compounds that could slow blood vessel growth
8. New blood test for Down syndrome
9. On the trail of a targeted therapy for blood cancers
10. Lower your blood pressure, hydrate your skin and reduce dental plaque -- with chocolate?
11. Building the blood-brain barrier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:4/1/2015)... Conn. , Apr. 1, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... of Wocket smart wallets is underway to early access ... access group includes usage at retail outlets including Walmart, ... Pharmacy. Users report Wocket was accepted at all outlets ...
(Date:3/31/2015)... , March 31, 2015  Elephant Talk Communications ... a global provider of Software Defined Network Architecture (ET ... announced total revenue of approximately $20.4 million for the ... restated $19.5 million for the year ended December 31, ... 2014, the Company had completed its multi-year transition away ...
Breaking Biology News(10 mins):Fingerprint Cards Revises Revenues for Q1 2015 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... A person,s ability to battle viruses at the cellular ... prions misfold and cluster native proteins to cause disease, ... marks the first discovery of so-called "good" prion-like proteins ... proteins involved in innate immunity: the way the body ...
... University professor is helping students improve their confidence ... learning. Candice Shoemaker, professor of horticulture, has ... and self-efficacy. Self-efficacy involves student confidence in understanding ... learning and achievement. Shoemaker,s published research appeared in ...
... be a leading cause of the decline of coral reefs ... Georgia have found that extreme low temperatures affect certain corals ... potentially catastrophic consequences for coral ecosystems. Their findings appear in ... Biology . Lead author Dustin Kemp, a postdoctoral associate ...
Cached Biology News:'Good' prion-like proteins boost immune response, UT Southwestern scientists report 2Finding their way: Study shows connection between academic direction and student learning 2Finding their way: Study shows connection between academic direction and student learning 3Study: Severe low temperatures devastate coral reefs in Florida Keys 2Study: Severe low temperatures devastate coral reefs in Florida Keys 3
(Date:5/4/2015)... May 4, 2015 GliaCure, a privately-held ... therapies for neurological and neuropsychiatric disorders based on ... of Alzheimer,s patients in a Phase 1b clinical ... compound developed as a potential disease-modifying treatment. GliaCure,s ... in that it both promotes the clearance of ...
(Date:5/4/2015)... 4, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... independent team of researchers from South ... (TB4) plays an important role in accelerating the ... an experimental mouse model, by promoting blood vessel ... dermal tissue.  The research found that the underlying ...
(Date:5/4/2015)... 2015 - New Massive Open ... prepare for the United States Medical Licensing Examination ... technical and medical information products and services, announced today ... Online Course) designed to help medical students prepare for ... the first and most daunting of the three exams ...
(Date:5/1/2015)... Md. , May 1, 2015  Northwest Biotherapeutics ... company developing DCVax® personalized immune therapies for solid tumor ... the $28.5 million second tranche of a $40 million ... Woodford first invested $25 million in NW ... Woodford entered into an agreement with the Company for ...
Breaking Biology Technology:GliaCure Initiates Phase 1b Dosing in Alzheimer's Patients 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 2Researchers Report that Thymosin B4 has a Major Role in Dermal Burn Wound Healing 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3
... May Help Increase Appropriate Early Use in Acute Coronary Syndrome ... ... 27 ,Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and Bristol-Myers Squibb,Company (NYSE: ... approved a supplemental new drug application,(sNDA) for a 300mg tablet of the ...
... CLATTERBRIDGE, England, Sept. 27 Varian,Medical Systems (NYSE: ... oncology centers,are jointly hosting Europe,s first IGRT (image ... be trained to use the,latest and most precise ... for Oncology (CCO) near Liverpool is the venue ...
... Project on Emerging Nanotechnologies, in collaboration with Consumers ... Online announces a major effort to reach out ... an important online conversation about the possible risks ... , This exciting online event, ConsumersTalkNano, will take ...
Cached Biology Technology:FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 2FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 3FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 4FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 5First European IGRT School Takes Place for Radiotherapy Practitioners in UK 2First European IGRT School Takes Place for Radiotherapy Practitioners in UK 3Project on Emerging Nanotechnologies and Consumers Union collaborate on 'ConsumersTalkNano' 2
Presenilin 2 Immunogen: Synthetic peptide corresponding to residues 31-47 of human Presenilin 2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
SHP-2 Antibody...
200 μg per ml DNA in 10 SSPE, 2 Denhardt's...
... Reacts with an early protein. ... 3 hours post-infection exhibiting an ... peak intensity between 6-24 hours. ... intense coarsely granular staining. ...
Biology Products: