Navigation Links
Activity in brain networks related to features of depression
Date:4/3/2012

Philadelphia, PA, April 3, 2012 Depressed individuals with a tendency to ruminate on negative thoughts, i.e. to repeatedly think about particular negative thoughts or memories, show different patterns of brain network activation compared to healthy individuals, report scientists of a new study in Biological Psychiatry.

The risk for depression is increased in individuals with a tendency towards negative ruminations, but patterns of autobiographic memory also may be predictive of depression.

When asked to recall specific events, some individuals have a tendency to recall broader categories of events instead of specific events. This is termed overgeneral memory and, like those who tend to ruminate, these individuals also have a higher risk of developing depression.

These self-referential activities engage a network of brain regions called the default mode network, or DMN. Prior studies using imaging techniques have already shown that the DMN activates abnormally in individuals with depression, but the relationship between DMN activity and depressive ruminations was not clear.

In this new report, Dr. Shuqiao Yao of Central South University in Hunan, China and colleagues evaluated DMN functional connectivity in untreated young adults experiencing their first episode of major depression and healthy volunteers. Each participant underwent a brain scan and completed tests to measure their levels of rumination and overgeneral memory.

As expected, the depressed patients exhibited higher levels of rumination and overgeneral memory than did the control subjects. They also observed increased functional connectivity in the anterior medial cortex regions and decreased functional connectivity in the posterior medial cortex regions in depressed patients compared with control subjects.

Among the depressed subjects, an interesting pattern of dissociation emerged. The increased connectivity in anterior regions was positively associated with rumination, while the decreased connectivity in posterior regions was negatively associated with overgeneral memory.

Dr. Yao commented on the importance of these findings: "In the future, resting-state network activity in the brain will provide useful models for investigating network features of cognitive dysfunction in psychopathology."

"As we dig deeper in brain imaging studies, we are becoming increasingly interested in the activity of brain circuits rather than single brain regions," said Dr. John Krystal, Editor of Biological Psychiatry. "Although it is a more complicated process, studying brain circuits may provide greater insight into symptoms, such as depressive ruminations. The current study nicely illustrates how altered activity at different sites within a brain network may be related to different features of depression."


'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related biology news :

1. Guidelines urge physical activity during pregnancy
2. How neuronal activity leads to Alzheimers protein cleavage
3. Earthworm activity can alter forests carbon-carrying capabilities
4. Physical activity and health: Finding the right prescription
5. Physical activity may not be key to obesity epidemic
6. Researchers capture wave of brain activity linked to anticipation
7. Inactivity of proteins behind longer shelf life when freezing
8. Pulmonary hypertension in children may result from reduced activity of gene regulator
9. Physical activity may strengthen childrens ability to pay attention
10. Early brain activity sheds new light on the neural basis of reading
11. Study finds childrens activity levels not influenced by more PE time in school
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Biopharm Reports has carried out a ... nuclear magnetic resonance spectroscopy (NMR). This involved the ... practices, developments, trends and end-user plans over the ... opportunities. These areas include growth in the use ... innovation requirements, hyphenated NMR techniques, main suppliers of ...
(Date:1/19/2017)... , January 19, 2017 According to a new ... and Forecast, 2014 - 2022," the global biometric sensor market is expected to ... to 2022. In 2015, Asia-Pacific dominated the global market ... private sectors. Continue Reading ... ...
(Date:1/13/2017)... 13, 2017 Sandata Technologies, LLC, a ... homecare industry, including Electronic Visit Verification™ (EVV™), announced ... Jugs, as Senior Vice President of Product Management. ... of homecare experience to Sandata, where he will ... to align Sandata,s suite of solutions with the ...
Breaking Biology News(10 mins):
(Date:2/15/2017)... WARRINGTON, Pa. , Feb. 15, 2017 /PRNewswire/ ... ), a biotechnology company focused on developing aerosolized ... that it has completed a $10.5 million private ... expects that it has sufficient capital to fund ... 2b clinical trial data release in mid-2017. ...
(Date:2/15/2017)... , ... February 15, 2017 , ... ... will hold its sixth annual open house and technology show, Morris Madness, March ... live metal cutting demos from Okuma, Tsugami and Hardinge Group in addition to ...
(Date:2/15/2017)... 2017  Surrozen Inc., a newly formed biopharmaceutical company ... repair and regeneration of human tissues, has closed a ... Group, a science-driven venture capital firm based in ... used to implement a broad-based drug discovery platform aimed ... plays a central role in organism development, stem-cell maintenance ...
(Date:2/15/2017)... Group, a leading cosmetics company in China ... world, the company has successfully printed the skin of Asians ... to assure the smooth and reliable progress of the project, ... cell biology, pharmaceutical and regenerative medicine scientists from both ... After 98 experiments, the R&D team built the first Asian ...
Breaking Biology Technology: