Navigation Links
'Activating' RNA takes DNA on a loop through time and space
Date:2/17/2013

Long segments of RNA encoded in our DNA but not translated into proteinare key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

In an online article of the journal Nature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits. "These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."

Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.

"Non-c
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3934
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC research takes a new approach to identifying food deserts
2. Building healthy bones takes guts
3. REACH news: European ombudsman takes up PETA complaint
4. Global Companion Diagnostic Market Worth $19.3 billion by 2023: What it Takes to Become a Major Companion Diagnostic Player
5. It takes two to tangle: Wistar scientists further unravel telomere biology
6. NSF interdisciplinary program takes on critical national research priorities
7. University of Leicester takes delivery of unique eye imaging equipment
8. ONR-funded research takes flight in Popular Science article
9. Barley takes a leaf out of reindeers book in the land of the midnight sun
10. Why do people choke when the stakes are high?
11. Explosive breakthrough in research on molecular recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... juillet 2015 La 10e Conférence internationale ... organisée par le BGI du 22 au 25 ... en Chine. La conférence célèbre son ... 2006, l,ICG est devenue l,une des réunions annuelles ... « omiques » et c,est aussi la plus dynamique, la ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s ... in 2015 that relate to sales of FPC1025 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... China and we are proud that ... Axon , its first smartphone ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... a common chemotherapy agent, researchers at UCLA's Jonsson Cancer ... found a way to move an important biomarker expressed ... in a cell ?where it could not be accessed ... The discovery, outlined in the cover article of May ...
... ended a decade-long controversy over the process by which ... ?the fragrant substances plants produce and which are often ... and other animals were incapable of making these substances. ... control pheromone production," said Gary Blomquist, professor and chair ...
... University of North Carolina at Chapel Hill's newest "library" ... book lover, but it eventually will please thousands of ... it will undoubtedly contribute to improving crops that humans ... say. , Named Phytome, the unique library is a ...
Cached Biology News:UCLA cancer researchers shake loose hidden biomarker 2Researchers discover key gene involved in bark beetle pheromone production 2Unique library of plant genes germinates, takes root at UNC 2
(Date:8/5/2015)... ... August 05, 2015 , ... MTI-GlobalStem, ... the launch of an updated corporate identity, including new company name, logo and ... in 2009. The company moved into a new, joint facility in 2014 to ...
(Date:8/4/2015)... (NYSE: BIOA ), a leader in renewable materials ... June 30, 2015. Highlights included: , The Sarnia plant ... final cost of the Sarnia plant is projected to ... end of the estimate communicated at the onset of ... company announced commercial collaborations in two targeted industry segments; ...
(Date:8/4/2015)... According to a new ... Cardiac Biomarker - Market Opportunities, and Forecast, 2014-2020", ... revenue of $2,085.9 million by 2020, registering a ... Troponins (T, I) would continue to dominate the ... sensitivity and specificity.      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:8/4/2015)... ... August 04, 2015 , ... RPS Diagnostics (RPS®) – a ... that Robert A. Gregg, PhD, has joined RPS as Senior Vice President of ... experience and remarkable achievements in the medical device and diagnostics industries. , “Bob ...
Breaking Biology Technology:MTI-GlobalStem Announces Updated Company Identity and Website 2MTI-GlobalStem Announces Updated Company Identity and Website 3BioAmber Reports Second Quarter 2015 Financial Results 2BioAmber Reports Second Quarter 2015 Financial Results 3BioAmber Reports Second Quarter 2015 Financial Results 4BioAmber Reports Second Quarter 2015 Financial Results 5BioAmber Reports Second Quarter 2015 Financial Results 6BioAmber Reports Second Quarter 2015 Financial Results 7BioAmber Reports Second Quarter 2015 Financial Results 8BioAmber Reports Second Quarter 2015 Financial Results 9BioAmber Reports Second Quarter 2015 Financial Results 10BioAmber Reports Second Quarter 2015 Financial Results 11BioAmber Reports Second Quarter 2015 Financial Results 12Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 3Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 4Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 5RPS Diagnostics Welcomes Robert Gregg as Senior Vice President of Clinical and Regulatory Affairs 2RPS Diagnostics Welcomes Robert Gregg as Senior Vice President of Clinical and Regulatory Affairs 3
... Dec. 17 Phosphagenics,Limited ("Phosphagenics") (ASX: POH, AIM: ... Phase 1 clinical trial that showed its,delivery technology, ... without causing disruption or irritation of any kind., ... the first company to,commercialize a sustained release oxycodone ...
... Provide Unprecedented Visibility into, Enterprise-Wide Spend Management Practices; Supplier Enablement Capability ... Spending with Preferred ... ... leader,in helping academic and research-centric organizations realize the,potential of strategic procurement, ...
... Dec. 17 /PRNewswire-FirstCall/ - Vasogen Inc.,(NASDAQ: VSGN ; ... clinical trial which is designed to support an ... for the treatment of patients,with NYHA Class II ... diligently on the ACCLAIM-II study,including the establishment of ...
Cached Biology Technology:Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 2Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 3AmSurg Selects SciQuest Eprocurement Solution to Automate Purchasing of Medical Goods and Services 2AmSurg Selects SciQuest Eprocurement Solution to Automate Purchasing of Medical Goods and Services 3Vasogen Provides an Update on ACCLAIM-II Preparations 2Vasogen Provides an Update on ACCLAIM-II Preparations 3Vasogen Provides an Update on ACCLAIM-II Preparations 4
... Arabidopsis thaliana is the first higher plant ... serves as the primary model organism for ... content on this microarray is derived from ... for Genomic Research (TIGR) and from the ...
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
... its manganese-containing reaction buffer, converts long double-stranded ... (1825 bp) interfering RNAs (siRNA) suitable for ... (1 l) of ShortCut RNase III is ... into siRNA suitable for RNA interference in ...
...
Biology Products: