Navigation Links
Activating P300 protein contributes to repair of hippocampal neuronal DNA injuries

Various medications have been developed to treat neurodegenerative disorders, and drugs without significant side effects are gaining widespread interest such disorders. Brain Research Institute of Synergon Consulting in Romania, led by Dragoş Crneci, found that the protein p300, which is a transcription co-activator required for consolidation of memories during specific learning tasks, is at the same time involved in DNA replication and repair, playing a central role in the long-patch pathway of base excision repair. Based on the evidence, they propose that learning tasks such as novel object recognition could be tested as possible methods of base excision repair facilitation, hence inducing DNA repair in the hippocampal neurons. If this method proves to be effective, it could be the start for designing similar tasks for humans, as a behavioral therapeutic complement to the classical drug-based therapy in treating neurodegenerative disorders. These findings were published in the Neural Regeneration Research (Vol. 8, No. 32, 2013).

Contact: Meng Zhao
Neural Regeneration Research

Page: 1

Related biology news :

1. Activating RNA takes DNA on a loop through time and space
2. ASU researchers develop new device to help image key proteins at room temperature
3. Enlisting cells protein recycling machinery to regulate plant products
4. Infrared sheds light on single protein complexes
5. Pathogen study explores blocking effect of E. coli O157:H7 protein
6. New genetic research finds shark, human proteins stunningly similar
7. Proteins passing phases revealed
8. Bad proteins branch out
9. 2-way traffic enable proteins to get where needed, avoid disease
10. Scientists prove X-ray laser can solve protein structures from scratch
11. Researchers gain fuller picture of cell protein reactions
Post Your Comments:
(Date:5/12/2016)... 2016 , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: