Navigation Links
Activated stem cells in damaged lungs could be first step toward cancer
Date:5/26/2009

DURHAM, N.C. Stem cells that respond after a severe injury in the lungs of mice may be a source of rapidly dividing cells that lead to lung cancer, according to a team of American and British researchers.

"There are chemically resistant, local-tissue stem cells in the lung that only activate after severe injury," said Barry R. Stripp, Ph.D., professor of medicine and cell biology at Duke University Medical Center. "Cigarette smoke contains a host of toxic chemicals, and smoking is one factor that we anticipate would stimulate these stem cells. Our findings demonstrate that, with severe injury, the resulting repair response leads to large numbers of proliferating cells that are derived from these rare stem cells."

Stripp said this finding could be related to the increased incidence of lung cancer in people with chronic disease states, in particular among cigarette smokers.

The findings were published in the advance online edition of the Proceedings of the National Academy of Sciences during the week of May 25.

"On the positive side, I think that it might be possible to improve lung function in the context of disease if we could understand which pathways regulate lung stem cell activation and then target these pharmacologically," said lead author Adam Giangreco, Ph.D., from Cancer Research UK's Cambridge Research Institute. "In terms of lung cancer susceptibility, however, our observation that stem cell activation leads to clonal expansion after injury could, in the context of additional mutations, promote the development of cancerous or precancerous lesions from activated stem cells."

The scientists used a chimeric mouse model, part wild-type and part with green fluorescent protein-tagged cells (GFP), so that the behavior of different populations of duplicating lung cells could be evaluated with high-resolution imaging methods. By understanding the extent to which GFP-positive and GFP-negative cells were mixed, the investigators were able to show that the abundant population of progenitor cells that normally maintain the epithelial layer in the lung could be rapidly wiped out with a strong chemical, naphthalene. Then the rare proliferative cells became active and grew into large patches.

The researchers at Duke and Cancer Research UK used a unique whole-lung imaging method to examine and identify the location of stem cells in the lung tissue of mice, and determine the role they play in both healthy and damaged mouse lungs.

They found that, while the stem cells don't appear to be involved in the normal maintenance of healthy or moderately injured lungs, they do play a vital role in repairing severely damaged lungs.

Even though this repair mechanism is important for restoring lung function, it can come at a price. An acquired mutation in that rare cell or its descendants leads to clonal patches of many identical cells. Secondary mutations in any one of these cells may provide the signals needed for unregulated cell growth and tumor progression.

"This work provides a plausible mechanism to account for this type of event that we previously didn't have," Stripp said.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert  

Related biology news :

1. Parus Interactive Awarded Patent for Speech-Activated Remote System Management
2. bioMETRX, Inc. Partners with Biometric Solutions, LLC to Deliver Next Generation Finger Activated Technology
3. Adult stem cells activated in mammalian brain
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. Newly created cancer stem cells could aid breast cancer research
6. AIDS interferes with stem cells in the brain
7. Clemson scientists shed light on molecules in living cells
8. Social habits of cells may hold key to fighting diseases
9. UF scientists reveal how dietary restriction cleans cells
10. Human derived stem cells can repair rat hearts damaged by heart attack
11. Scientists identify embryonic stem cells by appearance alone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Activated stem cells in damaged lungs could be first step toward cancer
(Date:2/28/2017)... Spanien, 27. Februar 2017  EyeLock LLC, ein marktführendes ... seine erstklassige biometrische Lösung zur Iris-Erkennung auf ... X16 LTE auf dem Mobile World Congress ... Qualcomm-Stand in Halle 3, Stand 3E10, vorstellen. ... Sicherheitsplattform Qualcomm Haven™ – eine Kombination aus ...
(Date:2/21/2017)... PORTLAND, Ore. , Feb. 22, 2017 /PRNewswire/ ... of Companies (Avamere Health Services, Infinity Rehab, Signature Hospice, ... study that will apply the power of IBM cognitive ... and health centers. By analyzing data streaming from sensors ... into physical and environmental conditions, and obtain deeper learnings ...
(Date:2/13/2017)... 2017 Former 9/11 Commission border counsel and ... Janice Kephart of Identity Strategy Partners, LLP, today ... "Executive Order: Protecting the Nation From Foreign Terrorist ... "As President Trump,s ,Travel Ban, Executive Order gains ... banned the travel ban, it is important that our ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... , March 27, 2017  Perthera,s Chief Bioinformatics ... Center, Subha Madhavan , Ph.D., will be speaking ... Summits Panels. On Monday, March 27, 2017, she will ... Data More Usable for Research and Care" (from 10:30 ... 28, 2017, she will be a participant in the ...
(Date:3/27/2017)... , March 27, 2017 DarioHealth Corp. (NASDAQ: ... health and big data solutions, today announced that it ... coverage option for U.S. consumers who want to have ... DarioHealth has signed strategic alliance agreements with partners across ... coverage benefits, and if approved, will supply and bill ...
(Date:3/24/2017)... Biotech Ltd. ("Sinovac" or the "Company") (NASDAQ: SVA), a leading provider ... that its board of directors has amended its shareholder rights plan. The ... 2017 to March 27, 2018. The amendment was not in response to ... ... Ltd. is a China -based biopharmaceutical company that ...
(Date:3/23/2017)... San Diego, Calif. (PRWEB) , ... March 23, 2017 , ... Lajollacooks4u is proud to ... in 2008, it has hosted corporate cooking challenges for companies around the world, such as ... , Part of the reason for its increasing popularity is due to its new ...
Breaking Biology Technology: