Navigation Links
Activated stem cells in damaged lungs could be first step toward cancer
Date:5/26/2009

DURHAM, N.C. Stem cells that respond after a severe injury in the lungs of mice may be a source of rapidly dividing cells that lead to lung cancer, according to a team of American and British researchers.

"There are chemically resistant, local-tissue stem cells in the lung that only activate after severe injury," said Barry R. Stripp, Ph.D., professor of medicine and cell biology at Duke University Medical Center. "Cigarette smoke contains a host of toxic chemicals, and smoking is one factor that we anticipate would stimulate these stem cells. Our findings demonstrate that, with severe injury, the resulting repair response leads to large numbers of proliferating cells that are derived from these rare stem cells."

Stripp said this finding could be related to the increased incidence of lung cancer in people with chronic disease states, in particular among cigarette smokers.

The findings were published in the advance online edition of the Proceedings of the National Academy of Sciences during the week of May 25.

"On the positive side, I think that it might be possible to improve lung function in the context of disease if we could understand which pathways regulate lung stem cell activation and then target these pharmacologically," said lead author Adam Giangreco, Ph.D., from Cancer Research UK's Cambridge Research Institute. "In terms of lung cancer susceptibility, however, our observation that stem cell activation leads to clonal expansion after injury could, in the context of additional mutations, promote the development of cancerous or precancerous lesions from activated stem cells."

The scientists used a chimeric mouse model, part wild-type and part with green fluorescent protein-tagged cells (GFP), so that the behavior of different populations of duplicating lung cells could be evaluated with high-resolution imaging methods. By understanding the extent to which GFP-positive and GFP-negative cells were mixed, the investigators were able to show that the abundant population of progenitor cells that normally maintain the epithelial layer in the lung could be rapidly wiped out with a strong chemical, naphthalene. Then the rare proliferative cells became active and grew into large patches.

The researchers at Duke and Cancer Research UK used a unique whole-lung imaging method to examine and identify the location of stem cells in the lung tissue of mice, and determine the role they play in both healthy and damaged mouse lungs.

They found that, while the stem cells don't appear to be involved in the normal maintenance of healthy or moderately injured lungs, they do play a vital role in repairing severely damaged lungs.

Even though this repair mechanism is important for restoring lung function, it can come at a price. An acquired mutation in that rare cell or its descendants leads to clonal patches of many identical cells. Secondary mutations in any one of these cells may provide the signals needed for unregulated cell growth and tumor progression.

"This work provides a plausible mechanism to account for this type of event that we previously didn't have," Stripp said.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert  

Related biology news :

1. Parus Interactive Awarded Patent for Speech-Activated Remote System Management
2. bioMETRX, Inc. Partners with Biometric Solutions, LLC to Deliver Next Generation Finger Activated Technology
3. Adult stem cells activated in mammalian brain
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. Newly created cancer stem cells could aid breast cancer research
6. AIDS interferes with stem cells in the brain
7. Clemson scientists shed light on molecules in living cells
8. Social habits of cells may hold key to fighting diseases
9. UF scientists reveal how dietary restriction cleans cells
10. Human derived stem cells can repair rat hearts damaged by heart attack
11. Scientists identify embryonic stem cells by appearance alone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Activated stem cells in damaged lungs could be first step toward cancer
(Date:2/2/2016)... YORK , Feb. 2, 2016 ... of that Rising Market Are you interested ... analysis forecasts revenues for checkpoint inhibitors. Visiongain,s report ... market, submarket, product and national level. Avoid ... discover what progress, opportunities and revenues those emerging ...
(Date:2/1/2016)... , February 1, 2016 Rising ... to drive global touchfree intuitive gesture control market ... Rising sales of consumer electronics coupled with new ... market size through 2020   ... coupled with new technological advancements to drive global touchfree ...
(Date:1/27/2016)... CHESTER, Ohio , Jan. 27, 2016  Rite ... supplier based in West Chester, Ohio ... their award winning service staff, based in ... technical capacity and ability to provide modifications, installations and ... John Dovalina , CEO of PLUS, commented, "PLUS has ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... ... February 12, 2016 , ... The ... Center in Atlanta, Georgia, will include 848 exhibitors (count as of February 9) ... displaying products and services used by the scientific community in industrial, academic, and ...
(Date:2/12/2016)... PLAINFIELD, N.J. , Feb. 12, 2016 /PRNewswire/ ... announced the second annual STRIVE (Strategies to Realize ... Duchenne muscular dystrophy (DMD). STRIVE provides funds to ... programs that will make meaningful contributions to the ... or fostering development of future patient advocates. ...
(Date:2/11/2016)... , February 11, 2016 Non-profit Consortium ... Genetic Understanding to Support Research and Discovery ... today announced an ambitious plan to sequence 100,000 individuals. It ... countries and at least 7 of North and East Asian ... the first phase, the project will focus on creating phased ...
(Date:2/11/2016)... AUSTIN, Texas , Feb. 11, 2016  Vermillion, ... focused on gynecologic disease, today announced the formation of ... --> --> Pelvic ... in both diagnosis and management. Once pregnancy is ruled ... fallopian tubes and ovaries, advanced endometriosis, benign ovarian tumors ...
Breaking Biology Technology: