The talk, "Field tests of a directional parametric acoustic alarm designed to alert manatees of approaching boats" (4aAB6) by Edmund Gerstein, Laura Gerstein, Joseph Blue, Josiah Greenewald, Narayan Elasmar is at 10:30 a.m. on Thursday, November 13.
6) MICROBUBBLES MAY BE KEY TO DRUG DELIVERY IN THE BRAIN
Many neurological disorders and neurodegenerative diseases, such as Alzheimer's and Parkinson's, remain difficult to treat because of the impermeability of the blood-brain barrier (BBB). Opening of the BBB noninvasively, transiently and with high spatial selectivity has been demonstrated using a combination of focused ultrasound (FUS) and microbubbles, allowing large molecules to infuse entire regions of the brain relevant in diseases such as Alzheimer's. However, while researchers know that this combination works, the mechanism of BBB opening remains unknown.
A team of researchers at Columbia University are trying to determine the bubble behavior, i.e., bubble oscillation and/or collapse, during focused ultrasound to gain an understanding not only of what occurs to open the blood-brain barrier but how it happens. Ultimately the goal of this research is to be able to effectively deliver drugs to the brain region where they are needed without affecting the surrounding healthy brain.
This research demonstrates that the microbubble is as important to BBB opening as the ultrasound itself, since the amount and extent of the region undergoing BBB opening depends both on the type, size and stability of the microbubble used. Both bubble oscillation and collapse can result at the ultrasound pressures used for BBB opening but selection of the right type of microbubble can determine whi
|Contact: Jason Bardi|
American Institute of Physics