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Acoustic tweezers capture tiny creatures with ultrasound
Date:6/29/2012

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"Acoustic tweezers will be used to position cells for interrogation by pulses of drug-like molecules to test as well as to exert mechanical forces on the cell wall," according to Stephen Benkovic, Evan Pugh Professor of Chemistry and holder of the Eberly Family Chair in Chemistry, whose group contributed to the paper, "The cells will contain bio-chemical markers, so we can observe the effect of drug pulses or pressure on the cell's biochemistry."

Acoustic tweezers are very versatile, said Huang. "We can manipulate a single cell or we can manipulate tens of thousands of cells at the same time."

Currently, the size of objects that can be moved with acoustic tweezers ranges from micrometers to millimeters, although with higher frequencies, it should be possible to move objects in the nanoscale regime, the researchers believe. Further work will include modifying the device to accommodate more fundamental biomedical studies with the Benkovic group.

Ultimately, the patent pending technology could lead to compact, noninvasive and inexpensive point-of-care applications, such as blood cell and cancer cell sorting and diagnostics. For now, the ability to trap and manipulate a living C. elegans for study is proof of their device's potential utility.


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Contact: Walt Mills
wem12@psu.edu
814-865-0285
Penn State
Source:Eurekalert  

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