Navigation Links
Accelerated bone turnover remains after weight loss
Date:7/28/2008

COLUMBIA, Mo. When a person is losing a significant amount of weight, they expect to notice changes in their body. However, they may overlook changes happening in their bones. During weight loss through calorie-restricted diets, bones are being remodeled - breaking down old bone and forming new bone - at an accelerated rate. At the same time, bone density is decreasing, causing increased fragility. In a new study, a University of Missouri researcher and collaborators at the University of Kansas found that the potentially harmful effects of weight loss on bone persist during weight maintenance following moderate weight loss.

Researchers examined protein markers of bone breakdown and formation in 37 obese, middle-aged adults who lost 20 percent of their body weight through a severe calorie-restricted diet. Protein markers, which are released during bone breakdown and formation, are used as indirect indicators of bone remodeling. During the 3-month weight-loss phase, bone remodeling was elevated, and bone formation and breakdown were imbalanced as a result of a low energy intake. After weight loss phase, bone remodeling remained elevated during the 9-month weight maintenance phase, but bone formation and breakdown appeared to be balanced.

"When people increased their calorie intake after weight loss, the bone remodeling markers did not respond and remained above what they were before weight loss," said Pam Hinton, associate professor of nutritional sciences in the MU College of Human Environmental Sciences. "However unlike the weight loss phase, it appeared that bone breakdown and bone formation were balanced. Rapid rates of bone remodeling, regardless of the balance of breakdown and formation, can increase bone fragility."

Hinton found that a greater reduction in body weight resulted in a greater increase in bone breakdown. Having a low-carbohydrate or a low-fat diet during the weight maintenance phase had no effect on bone remodeling in the participants. Hinton also found that gender, hormone replacement therapy and menopausal status did not affect changes in bone remodeling markers and body weight. Previous studies have reported elevated bone formation and breakdown and decreased bone mass after modest weight reduction in a 6 to 12 month period, Hinton said.

"From this study alone, it is impossible to determine the consequences of accelerated bone remodeling during weight maintenance," Hinton said. "Because bone strength adapts to match skeletal load, body weight is one of the strongest predictors of bone mass. People planning on losing a significant amount of weight should consider incorporating high-impact weight-bearing physical activity into their exercise routine and consuming adequate calcium to improve bone health."


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. New technique determines the number of fat cells remains constant in all body types
2. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
3. Video released of rapid Alzheimers improvement after new immune-based treatment
4. Dioxin risk in soil and plant tissues after long-term biosolids application
5. Children born from frozen embryos weigh more and do better than those born after fresh transfer
6. Children born after donor insemination should be told as soon as possible about their conception
7. Resuscitation technique after brain injury may do more harm than good
8. Dwarf cloud rat rediscovered after 112 years
9. Pregnancy is possible after cancer treatment
10. Many African-Americans have a gene that prolongs life after heart failure
11. Breast cancers behave differently before and after the age of 70
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... 13, 2017 According to a new market research ... Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and ... is expected to grow from USD 14.30 Billion in 2017 to USD ... 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... , ... August 14, 2017 , ... The Conference ... event, which will take place on September 6, 2017 at the Marriott Copley ... , Head of Experimental Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, ...
(Date:8/11/2017)... WI (PRWEB) , ... August 11, 2017 , ... ... in food production, and, in particular, more natural alternatives to synthetic ingredients,” said ... innovation of Third Wave, with the established manufacturing presence and know-how of Biorigin ...
(Date:8/10/2017)... ... August 09, 2017 , ... Each year in the United States ... enough to live an independent lifestyle and, even worse, the one-year mortality rate is ... doctors at the University of California Davis Medical Center (Sacramento) and Second Xiangya Hospital ...
(Date:8/10/2017)... Washington, USA, and CARDIFF, UK (PRWEB) , ... ... ... optics and photonics, has announced an agreement establishing Kinokuniya Company Ltd. as its ... with SPIE as the exclusive sales representative for the SPIE Digital Library in ...
Breaking Biology Technology: