Navigation Links
Accelerated bone turnover remains after weight loss

COLUMBIA, Mo. When a person is losing a significant amount of weight, they expect to notice changes in their body. However, they may overlook changes happening in their bones. During weight loss through calorie-restricted diets, bones are being remodeled - breaking down old bone and forming new bone - at an accelerated rate. At the same time, bone density is decreasing, causing increased fragility. In a new study, a University of Missouri researcher and collaborators at the University of Kansas found that the potentially harmful effects of weight loss on bone persist during weight maintenance following moderate weight loss.

Researchers examined protein markers of bone breakdown and formation in 37 obese, middle-aged adults who lost 20 percent of their body weight through a severe calorie-restricted diet. Protein markers, which are released during bone breakdown and formation, are used as indirect indicators of bone remodeling. During the 3-month weight-loss phase, bone remodeling was elevated, and bone formation and breakdown were imbalanced as a result of a low energy intake. After weight loss phase, bone remodeling remained elevated during the 9-month weight maintenance phase, but bone formation and breakdown appeared to be balanced.

"When people increased their calorie intake after weight loss, the bone remodeling markers did not respond and remained above what they were before weight loss," said Pam Hinton, associate professor of nutritional sciences in the MU College of Human Environmental Sciences. "However unlike the weight loss phase, it appeared that bone breakdown and bone formation were balanced. Rapid rates of bone remodeling, regardless of the balance of breakdown and formation, can increase bone fragility."

Hinton found that a greater reduction in body weight resulted in a greater increase in bone breakdown. Having a low-carbohydrate or a low-fat diet during the weight maintenance phase had no effect on bone remodeling in the participants. Hinton also found that gender, hormone replacement therapy and menopausal status did not affect changes in bone remodeling markers and body weight. Previous studies have reported elevated bone formation and breakdown and decreased bone mass after modest weight reduction in a 6 to 12 month period, Hinton said.

"From this study alone, it is impossible to determine the consequences of accelerated bone remodeling during weight maintenance," Hinton said. "Because bone strength adapts to match skeletal load, body weight is one of the strongest predictors of bone mass. People planning on losing a significant amount of weight should consider incorporating high-impact weight-bearing physical activity into their exercise routine and consuming adequate calcium to improve bone health."


Contact: Kelsey Jackson
University of Missouri-Columbia

Related biology news :

1. New technique determines the number of fat cells remains constant in all body types
2. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
3. Video released of rapid Alzheimers improvement after new immune-based treatment
4. Dioxin risk in soil and plant tissues after long-term biosolids application
5. Children born from frozen embryos weigh more and do better than those born after fresh transfer
6. Children born after donor insemination should be told as soon as possible about their conception
7. Resuscitation technique after brain injury may do more harm than good
8. Dwarf cloud rat rediscovered after 112 years
9. Pregnancy is possible after cancer treatment
10. Many African-Americans have a gene that prolongs life after heart failure
11. Breast cancers behave differently before and after the age of 70
Post Your Comments:
(Date:11/12/2015)...   Growing need for low-cost, easy to ... paving the way for use of biochemical sensors ... in clinical, agricultural, environmental, food and defense applications. ... medical applications, however, their adoption is increasing in ... emphasis on improving product quality and growing need ...
(Date:11/9/2015)... , Nov. 09, 2015 ... the addition of the "Global Law ... their offering. --> ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... Research and Markets ( ) has ...
(Date:10/29/2015)... 2015   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce that it has ... as one of only three finalists for a ... and Growing" category. The Tekne Awards honor Minnesota ... technology innovation and leadership. iMedNet™ eClinical ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... ... November 25, 2015 , ... A ... Black Aerospace Professionals (OPBAP) has been formalized with the signing of a Memorandum ... met with OPBAP leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November ...
(Date:11/24/2015)... ... November 24, 2015 , ... The United States Golf Association (USGA) ... USGA Green Section Award. Presented annually since 1961, the USGA Green Section Award recognizes ... with turfgrass. , Clarke, of Iselin, N.J., is an extension specialist of ...
(Date:11/24/2015)... Florida (PRWEB) , ... November 24, 2015 , ... ... biggest event of the year and one of the premier annual events for ... and ran from 8–11 November 2015, where ISPE hosted the largest number of ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model Aeronautics (AMA), ... MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View (FPV) racing ... AMA members have embraced this type of racing and several new model aviation pilots ...
Breaking Biology Technology: