Navigation Links
Abuse of painkillers can predispose adolescents to lifelong addiction
Date:9/10/2008

No child aspires to a lifetime of addiction. But their brains might. In new research to appear online in the journal Neuropsychopharmacology this week, Rockefeller University researchers reveal that adolescent brains exposed to the painkiller Oxycontin can sustain lifelong and permanent changes in their reward system changes that increase the drug's euphoric properties and make such adolescents more vulnerable to the drug's effects later in adulthood.

The research, led by Mary Jeanne Kreek, head of the Laboratory of the Biology of Addictive Diseases, is the first to directly compare levels of the chemical dopamine in adolescent and adult mice in response to increasing doses of the painkiller. Kreek, first author Yong Zhang, a research associate in the lab, and their colleagues found that adolescent mice self-administered Oxycontin less frequently than adults, suggesting that adolescents were more sensitive to its rewarding effects. These adolescent mice, when re-exposed to a low dose of the drug as adults, also had significantly higher dopamine levels in the brain's reward center compared to adult mice newly exposed to the drug.

"Together, these results suggest that adolescents who abuse prescription pain killers may be tuning their brain to a lifelong battle with opiate addiction if they re-exposed themselves to the drug as adults," says Kreek. "The neurobiological changes seem to sensitize the brain to the drug's powerfully rewarding properties."

During adolescence, the brain undergoes marked changes. For example, the brain's reward pathway increases production of dopamine receptors until mid-adolescence and then either production declines or numbers of receptors decline. By abusing Oxycontin during this developmental period, adolescents may inadvertently trick the brain to keep more of those receptors than it really needs. If these receptors stick around and the adolescent is re-exposed to the drug as an adult, the rush
'/>"/>

Contact: Thania Benios
tbenios@rockefeller.edu
212-327-7146
Rockefeller University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Surviving the revolution, easier than withstanding human use and abuse
2. Study finds possible connection between marijuana abuse and stroke or heart attacks
3. A research of the UGR shows the genetic predisposition to develop alcohol abuse
4. Are some men predisposed to pedophilia?
5. Risks and benefits of antipsychotics in children and adolescents
6. Learning how to say no to alcohol advertising and peer pressure works for inner-city adolescents
7. Cocaine: How addiction develops
8. Large-scale investment catapults CAMHs mental illness and addiction research forward
9. Erasing drug-associated memories may stop drug addiction relapses
10. Corals addiction to junk food
11. Hungry mothers risk addiction in their adult children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... nocturnal animals, bats are perfectly adapted to a life without ... the reflected echoes to measure distance to obstacles or prey. ... echo delays. A study carried out by researchers at Technische ... this map dynamically adapts to external factors. , ... flies in too close to an object, the number of ...
(Date:8/31/2014)... a fast and accurate tool to diagnose tuberculosis ... newly developed test (TAM-TB assay) is the first ... children. The test features excellent specificity, a similar ... of a blood test. The promising findings are ... in children, particularly in tuberculosis-endemic regions. , The ...
(Date:8/31/2014)... not busy attacking us, germs go after each other. ... disaster for the infected microbes: Sometimes viruses actually carry ... expand its diet or better attack its own hosts. ... immune system would robotically destroy anything it recognized as ... have now revealed that one variety of the bacterial ...
Breaking Biology News(10 mins):Zooming in for a safe flight 2New tuberculosis blood test in children is reliable and highly specific 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3
... A genetic variant of a receptor in the ... whether the neurotransmitter dopamine is released in the brain ... researchers at the National Institute on Alcohol Abuse and ... Dopamine is involved in transmitting the euphoria and ...
... first time successfully imaged the internal tissues of a ... technique borrowed from biomedical science. The findings are published ... worms are important for the functioning of marine ecosystems, ... understand their physiology, ecology and evolution," explained John Dinley ...
... imbalances at the heart of childhood brain tumors known as ... active in some tumors and is now the focus of ... research, published in the May 17 online edition of the ... between the defects underlying these tumors in children and adults, ...
Cached Biology News:Receptor variant influences dopamine response to alcohol 2Scientists use biomedical technique to image marine worm 2Push to understand basis of childhood brain tumors leads to a new treatment target 2Push to understand basis of childhood brain tumors leads to a new treatment target 3
(Date:9/2/2014)... 2, 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... property, today announced that the United States Patent & ... in the month of August that are part of ... The issued patents are: , U.S.RE45,065 ... 19, 2014; and , U.S.RE45,095 issued August 26, ...
(Date:9/1/2014)... 1, 2014 Reportlinker.com announces that a ... catalogue: India Solid Waste Management Vehicles ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In ... governing bodies responsible for complete handling and regulation ... average, around 135,000 MT solid waste is generated ...
(Date:8/31/2014)... 2014 Wockhardt Limited today announces a major ... research when two of its drugs, WCK 771 and ... (QIDP) status from U.S. Food & Drug Administration (FDA). ... pathogens which have a high degree of unmet need ... Disease Control (a top U.S. government health and safety ...
(Date:8/31/2014)... 31, 2014 This is a ... of the Epoxy Hardener industry in Global ... of the industry, including definitions, applications and industry ... market analysis are provided with a focus on ... market. A comparison between the international and Chinese ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
... , , , , , , ... The time increment, which can be programmed as desired with every temperature , ... temperature for each cycle. , , With ... successive extension of the , elongation. , ...
... for Detecting Listeria monocytogenes , , ... Andrea Tanzer and Christian Rohrer , Andrea Tanzer, Institute ... Christian Rohrer, Eppendorf AG, Germany, , , ... Bacterial enteritides, which are triggered by contaminated foodstuffs, , ...
... , , , , ... Dietmar Kahle, PhD , Peter Scheinert, PhD, Bernhard-Nocht-Institute ... Hamburg , former address: University of Kiel, Institute ... , Barbara Behrens, PhD, and Dietmar Kahle, PhD, Eppendorf-Netheler-Hinz ...
Cached Biology Technology:Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 2Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 3Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 4Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 5Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 6Two-dimensional Optimization of a Semi-nested PCR, for Detecting Listeria monocytogenes 7Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 2Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 3Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 4Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 5Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 6Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 7Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 8Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 9Optimizing DNA Amplification Protocols using the Eppendorf Mastercycler 10
The FliTrx Panning Kit is designed to simplify panning for protein-protein interactions with the FliTrx Random Peptide Display Library or the pFliTrx Peptide Display Vector....
... The GeneSwitch Cell Lines stably express ... Each cell line is functionally tested ... with the expression control vector pGene/V5-His/lacZ ... after treatment with mifepristone (Figure 1). ...
... Modules Highly efficient ... cloning into advanced λ ... For flexibility ... Systems, the modules of ...
... Re-Blot Western Blot Recycling Kit is ... Western blots that have been developed ... other isotopes. It is not recommended ... 4-chloronapthol, etc.), as it is not ...
Biology Products: