Navigation Links
Abnormal fat metabolism underlies heart problems in diabetic patients
Date:8/13/2007

St. Louis, Aug. 10, 2007 Heart disease hits people with diabetes twice as often as people without diabetes. In those with diabetes, cardiovascular complications occur at an earlier age and often result in premature death, making heart disease the major killer of diabetic people. But why is heart disease so prevalent among diabetics?

To help answer that question, researchers at Washington University School of Medicine in St. Louis have been analyzing the fat (lipid) composition of heart tissue from laboratory mice with diabetes. They have found that heart cells of diabetic mice lose an important lipid from cellular components that generate energy for the heart, and their latest research shows this happens at the very earliest stages of diabetes.

"Diabetic hearts run mostly on fats for fuel because glucose isn't readily available to them," says Richard Gross, M.D., Ph.D., director of the Division of Bioorganic Chemistry and Molecular Pharmacology and professor of medicine, of chemistry and of molecular biology and pharmacology. "Unfortunately, this change in metabolism distorts the lipid composition of cell membranes causing abnormal physical properties and cellular dysfunction."

The important lipid that the researchers found to be decreased in diabetes is cardiolipin. "Cardiolipin" literally means heart fat, and the term was coined because cardiolipin was first discovered in beef hearts and is one of the most abundant lipids in heart tissue. This lipid has unusual physical properties that are essential for the operation of the energy-producing cell structures called mitochondria.

When mitochondria lose a lot of their cardiolipin, they malfunction. Their malfunction not only interferes with the energy supply of heart muscle cells, it also increases the amount of damaging oxygen-containing substances in the cells, creating unhealthy conditions that can lead to heart problems.

Interestingly, a rare genetic disorder Barth syndrome held
'/>"/>
Contact: Gwen Ericson
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. North & South American researchers find architectural abnormalities in T. cruzi ribosome
2. Model identifies genes that induce normal skin cells to become abnormal
3. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
4. Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm
5. Chromosomal abnormalities in sperm higher after vasectomy reversal
6. Abnormal overexpression of p53 is a predictive molecular biomarker
7. Opposing fat metabolism pathways triggered by a single gene
8. Attacks of King George IIIs madness linked to key metabolism molecule
9. Computational model simulates AZT metabolism in mitochondria
10. Researchers attack tumor cells by exploiting dependency on sugar metabolism
11. Huddling and a drop in metabolism allow penguins to survive the South Pole cold
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... report analyzes the worldwide markets for Face and Voice Biometrics in ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , Middle East ... Latin America . Annual estimates and forecasts are provided for ... provided for these markets. Market data and analytics are derived from ...
(Date:2/18/2015)... 18, 2015  Cepheid (NASDAQ: CPHD ) today ... conferences, and invited investors to participate via webcast. , ... Tuesday, March 3, 2015 at 11.20 a.m. Eastern ... Orlando, FL Wednesday, March 4, 2015 at 10.25 ... the live webcasts for these events, please visit Cepheid,s website ...
(Date:2/11/2015)... According to a ... Product (Cards and Readers, Biometrics, Controllers, Management Software), ... Healthcare, Education) and By Geography - Global Forecast and Analysis to ... Control Market is expected to reach $10.4 ... of 10.6% between 2014 and 2020. ...
Breaking Biology News(10 mins):World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... in the abundance of fish, shellfish, and other aquatic fauna ... in the sea: historical records show that species in rivers ... of these declines in freshwater species is frequently overlooked by ... 2009 issue of BioScience . , Authors Paul Humphries ...
... to any process by which a cell converts one ... of signal transduction involve ordered sequences of biochemical reactions ... and activated by second messengers, resulting in a signal ... the order of milliseconds in the case of ion ...
... of French scientists have found the dose of DHA (docosahexaenoic ... healthy men. In a research report appearing in the September ... http://www.fasebj.org ), the scientists show that a 200 mg dose ... that reliably predict cardiovascular problems, such as those related to ...
Cached Biology News:Shifting baselines confound river restoration 2
(Date:2/26/2015)... 2015 On behalf of biotech client ... Wilentz, Goldman & Spitzer, P.A. (Wilentz) secured a significant ... Inc. in excess of $10 million. The jury determined ... and that it improperly hired one or more of ... for judgment notwithstanding the verdict, a new trial, and ...
(Date:2/26/2015)... , Feb. 26, 2015   Regulus Therapeutics Inc ... leading the discovery and development of innovative medicines targeting ... Ph.D., President and Chief Executive Officer of Regulus, will ... 35 th Annual Healthcare Conference on Wednesday, March ... being held at the Boston Marriott Copley Place.  ...
(Date:2/26/2015)... On behalf of biotech client GenScript ... Goldman & Spitzer, P.A. (Wilentz) secured a significant ... Inc. in excess of $10 million. The jury determined ... and that it improperly hired one or more of ... motions for judgment notwithstanding the verdict, a new trial, ...
(Date:2/26/2015)... 26, 2015 The Pittcon 2015 ... the Ernest N. Morial Convention Center in New ... of February 19, 2015) displaying products and services ... and government labs. The Exposition will offer the ... limited to, analytical chemistry; drug discovery; nanotechnology; life ...
Breaking Biology Technology:Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Pittcon 2015 Announces Exposition Highlights 2
... For the second year in a row, BioTrends Research ... companies in the Philadelphia region by the Philadelphia 100, a joint ... of Greater Philadelphia, and the Philadelphia Business Journal. , ... become an established player in the field of syndicated market research ...
... , , SEATTLE, Sept. 8 ... today that executives will present a corporate update at the ... Peter Thompson, M.D., FACP, president, chief executive officer and chairman ... president and chief financial officer, are scheduled to present on ...
... - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ONCY ... the Rodman Renshaw 11th Annual Healthcare Conference on ... will be held at the New York Palace Hotel from ... of the presentation will be available at: http://www.wsw.com/webcast/rrshq15/oncy ...
Cached Biology Technology:BioTrends Research Group is Recognized by the Philly 100 for the Second Consecutive Year 2Trubion Pharmaceuticals, Inc. to Present at the Morgan Stanley Global Healthcare Conference 2Media Advisory - Oncolytics Biotech Inc. to Present at Rodman Renshaw 11th Annual Healthcare Conference 2
Recombinant Rat CINC-2 alpha, CF...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to NP-BSA....
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Biology Products: