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Abnormal activation of a protein may explain deadly link between high salt intake and obesity
Date:9/19/2011

ssure and the kidneys.

Importance of the Findings

According to Dr. Fujita, the team's findings carry important implications for the treatment of hypertension. "Our data indicate that the Rac1-mediated pathway in the kidneys can be an alternative therapeutic target for salt-sensitive hypertension and salt-mediated kidney injury," he said. "Based upon our results, we can speculate that Rac1 in the kidneys regulates salt susceptibility of blood pressure, and that Rac1 inhibitors, as well as MR antagonists, may be effective in the treatment of salt-sensitive hypertension."


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Contact: Donna Krupa
dkrupa@the-aps.org
7-301-634-7209
American Physiological Society
Source:Eurekalert

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