Navigation Links
Abnormal activation of a protein may explain deadly link between high salt intake and obesity
Date:9/19/2011

Bethesda, Md. (Sept. 19, 2011) Dietary salt intake and obesity are two important risk factors in the development of high blood pressure. Each packs its own punch, but when combined, they deliver more damage to the heart and kidneys than the sum of their individual contributions. Discovering the molecular mechanisms behind this lethal synergy has presented a challenge to scientists, but research led by Toshiro Fujita, MD, professor and chairman of the Department of Internal Medicine and chief of the Department of Nephrology and Endocrinology at the University of Tokyo, suggests that high dietary salt intake and obesity work together to trigger an abnormal activation of a cellular protein called Rac1.

How Obesity and a High-Salt Diet Team Up

Dr. Fujita's team studied the effects of a high-salt diet in rats bred to have high blood pressure and different levels of blood pressure sensitivity to salt. When obese "salt-sensitive" rats were fed a high-salt diet, the team found that Rac1 activated the mineralocorticoid receptor (MR) on the rats' kidney cells. This receptor is normally activated by the hormone aldosterone. When turned on, MR leads to the expression of a protein called epithelial sodium channel (ENaC) and an enzyme called the sodium pump. Both of these substances promote the reabsorption of salt, which causes the body to retain fluid and results in high blood pressure. This is the first time scientists have seen Rac1 usurp aldosterone's role in activating MR in the regulation of blood pressure. The protein's usual duties entail regulating an array of cellular events such as cell growth.

The team made the discovery when attempting to treat the obese, hypertensive rats with drugs designed to block MR activation and inhibit Rac1. When Rac1 inhibitors were successful in lowering the rats' blood pressure, the team knew they had discovered a mechanism by which obesity and a high-salt diet team up to wreak havoc on blood pressure and the kidneys.

Importance of the Findings

According to Dr. Fujita, the team's findings carry important implications for the treatment of hypertension. "Our data indicate that the Rac1-mediated pathway in the kidneys can be an alternative therapeutic target for salt-sensitive hypertension and salt-mediated kidney injury," he said. "Based upon our results, we can speculate that Rac1 in the kidneys regulates salt susceptibility of blood pressure, and that Rac1 inhibitors, as well as MR antagonists, may be effective in the treatment of salt-sensitive hypertension."


'/>"/>

Contact: Donna Krupa
dkrupa@the-aps.org
7-301-634-7209
American Physiological Society
Source:Eurekalert

Related biology news :

1. Study finds chronic abnormal brain blood flow in Gulf War veterans
2. BMC awarded NIH grant to study brain abnormalities in former ELGANS patients
3. Early embryos can correct genetic abnormalities during development
4. Could ovarian stimulation cause an increase in oocyte chromosome abnormalities?
5. Electronic tracking system can improve follow-up after an abnormal Pap test
6. UT MD Anderson study ties abnormal cells in blood to lung cancer
7. Brain abnormalities in Parkinsons patients develop before symptoms occur
8. New chromosomal abnormality identified in leukemia associated with Down syndrome
9. Abnormal brain circuits may prevent movement disorder
10. New test can detect both genetic and chromosomal abnormalities in embryos
11. High carbon dioxide levels cause abnormally large fish ear bones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/6/2017)... April 6, 2017 Forecasts by ... Document Readers, by End-Use (Transportation & Logistics, Government & ... Gas & Fossil Generation Facility, Nuclear Power), Industrial, Retail, ... Are you looking for a definitive report ... ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... 20, 2017 , ... Cybrexa Therapeutics , a start-up ... role of chief scientific officer. In this role, Dr. Paralkar will lead the ... CEO, Per Hellsund. , “I was impressed with Cybrexa’s revolutionary technology and excellent ...
(Date:9/20/2017)... MD (PRWEB) , ... September 20, 2017 , ... ... digital pathology, and Huron Digital Pathology , a provider of whole slide ... 2017 Pathology Visions conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy ...
(Date:9/20/2017)... , ... September 20, 2017 , ... ... focused on molecular manufacturing and other transformative technologies, announced the winners for the ... and the other for Theory in nanotechnology/molecular manufacturing. , Established in 1993 and ...
(Date:9/19/2017)... ... September 19, 2017 , ... Participants of this ... high-performance fume hood. Along with the advantages and disadvantages of ductless, filtered fume ... hoods in the laboratory. , Attendees will learn from an industry expert about ...
Breaking Biology Technology: