Navigation Links
Ability to isolate and grow breast tissue stem cells could speed cancer research
Date:5/7/2014

nd stained them so that new stem cells appeared a different color from differentiated mammary cells. Then, they began testing the effects of two proteinsknown as CRIPTO and GRP78that play significant roles in both stem cell biology and embryonic development.

"In normal conditions, we first see the cells as yellowthe combination of red and green within a single cellthen later see cells that are either red or green, showing that our cells had the capacity to make two different types of mature cells," says Spike. "But then when we do the experiment again and start changing protein levels, the ratio of these cells becomes very different."

The researchers found that when they blocked CRIPTO, the cells mostly formed differentiated cells instead of new stem cells. Over time, this stem cell population shrank since they weren't repopulating themselves. When they instead boosted levels of CRIPTO, the stem cell colony grew as new stem cells were produced more often than differentiated cells.

In studies in mice, the scientists also found that CRIPTO helped the animals form new mammary tissues, which led the team to hypothesize that CRIPTO may be produced by nearby cells in the fat to spur the growth of breast tissue.

In a previous study, Gray's group had discovered that the protein GRP78 binds CRIPTO on the surface of cells and regulates CRIPTO function. This prompted the scientists to test whether GRP78 had an effect on the mammary stem cells. As they suspected, when cells lacked GRP78 on their surfaces, they didn't respond to CRIPTO.

Both CRIPTO and GRP78 have been implicated in cancers, including breast cancer and lung cancers. Scientists think high levels of either protein could encourage tumor growth using similar pathways that they use to spur breast tissue growth. With the new ability to isolate and sustain mammary stem cells, Spike and Gray hope they can uncover details on exactly what cellular programs CRIPTO and GRP78 activate. U
'/>"/>

Contact: Chris Emery
Cemery@salk.edu
858-453-4100
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Ancient civilizations reveal ways to manage fisheries for sustainability
2. New genetic bar code technique establishes ability to derive DNA information from RNA
3. University of Minnesota invention helps advance reliability of alternative energy
4. Estrogen hormone reveals protective ability after traumatic brain injury
5. New form of intellectual disability discovered
6. Evidence of familial vulnerability for epilepsy and psychosis
7. Science, Innovation, and Partnerships for Sustainability -- Symposium May 16-18
8. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
9. New treatment for irritability in autism
10. Ability to estimate quantity increases in first 30 years of life
11. Computing advances vital to sustainability efforts; new report recommends problem-focused, iterative approach to research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Ability to isolate and grow breast tissue stem cells could speed cancer research
(Date:7/31/2015)... , 31 de julio de 2015 ... (ICG-10,  www.icg-10.org ) del 22 al 25 de octubre ... La conferencia celebra su décimo aniversario este ... convertido en una de las reuniones anuales más influyentes ... es una de las conferencias científicas más dinámicas, entusiastas ...
(Date:7/31/2015)... 2015 La 10e Conférence internationale sur ... par le BGI du 22 au 25 octobre ... Chine. La conférence célèbre son 10e ... l,ICG est devenue l,une des réunions annuelles mondiales ... et c,est aussi la plus dynamique, la plus ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... rubbed on the skin to reduce signs of aging and ... the first evidence of one of vitamin E,s normal body ... tears in the plasma membranes that protect cells from outside ... University researchers report in the journal Nature Communications ., ...
... is an adorable doe-eyed bat with a dark side it ... Tsang, a PhD student in ecology and evolutionary biology at The ... to a revolutionary way to help fund her research into how ... viruses can spread from flying foxes to humans by tracing the ...
... Researchers at the University of Delaware are examining tiny ... not only how these organisms adapt to the severe cold, ... The National Science Foundation study, led by Adam Marsh, ... Ocean, and Environment, also will compare the process of temperature ...
Cached Biology News:Scientists identify an innate function of vitamin E 2Crowdfunding science: Student raises cash online to follow a flying fox 2Crowdfunding science: Student raises cash online to follow a flying fox 3Will Antarctic worms warm to changing climate? 2Will Antarctic worms warm to changing climate? 3
(Date:9/1/2015)... ... September 01, 2015 , ... ... release of a groundbreaking new version of its flagship DNA design platform, which ... down complex DNA sequences into numerous genetic parts, which in turn can be ...
(Date:8/31/2015)... MabVax Therapeutics Holdings, Inc. (OTCQB: MBVX) aclinical ... lead antibody, HuMab 5B1, will be garnering major attention ... upcoming World Molecular Imaging Congress (WMIC) being held in ... from the Department of Radiology at Memorial Sloan Kettering ... of MabVax,s lead antibody as a PET imaging agent ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
(Date:8/31/2015)... 31, 2015 FLX Bio, Inc., a biopharmaceutical ... cancer immunotherapies, announced today that it has appointed ... and William Ho , M.D., Ph.D., as Chief ... management team led by veterans of Flexus Biosciences, Inc., ... Scientific Officer; Jay Powers , Ph.D., Vice President, ...
Breaking Biology Technology:GenoCAD Releases Combinatorial Design Tool to Optimize Protein Expression and Streamline DNA Synthesis Orders 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4New Down syndrome therapy discovered 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4
... into why and how nanowires take the form they ... future electronic components. PhD student Peter Krogstrup from the ... the sensational new theoretical model, which is developed in ... One of the most important components in future electronic ...
... How would you like to store all the films ever ... Magnets made of just a few metallic atoms could make ... also recently been proposed as components for spintronics devices. There,s ... been seen to work at temperatures a few hairs above ...
... Group, Inc.  (OTC Bulletin Board: MDXG ), ... biomaterial-based products and bioimplants processed from human amniotic membrane, ... 31, 2010. Full Year 2010 ResultsIn ... with the calendar year. Its prior fiscal year was ...
Cached Biology Technology:Major advance in understanding how nanowires form 2Heavy metals open path to high temperature nanomagnets 2MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Biology Products: