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AVAC comments on NIAID decision not to move forward with PAVE 100 Trial
Date:7/17/2008

frank and challenging debate from a diverse, independent group of scientific leaders in the field. Within this group, the majority felt that important information could be gleaned from testing the VRC strategy that would have been used in PAVE 100. Many also voiced some concern that scaling back the trial design could lead to results that might be difficult to interpret or less useful than they could be. It will be critical to pursue these issues further and to closely consider the appropriate design for a scaled-back study.

"NIAID has stated that it will consider a proposal for such a trial. This new proposal must be subject to an even higher level of consultation and discussion that has taken place to date, and there must be adequate investment by NIAID in this process.

"This will not be the last time that the scientific community is asked to weigh in on whether or not an AIDS vaccine trial should go forward. This most recent development should be a guide to NIAID and the entire field on how to improve the decision-making process for the future. At a minimum, such a process must include more rigorous and legitimate community input," Warren said.

In the debates and discussions that have led up to this decision, many members of the scientific community have, along with AVAC, affirmed the value of clinical research as a vital component of the search for an AIDS vaccine. Although this one trial will not happen, AIDS vaccine research involving humans can, will and must continue.

"This decision in no way signals an end to the involvement of volunteers in the search for a safe and effective AIDS vaccine," Warren added. "AVAC believes that the field must redouble efforts to develop and implement a broad scientific agenda that includes basic science, preclinical work, and human trials of promising HIV vaccine candidates."

Many communities around the world, including here in the U.S., are ravaged by HIV/AIDS. AVAC will continue to work with researche
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Contact: Mitchell Warren
mitchell@avac.org
914-661-1536
AIDS Vaccine Advocacy Coalition (AVAC)
Source:Eurekalert

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